Discontinuation of levetiracetam because of behavioral side effects: A case-control study

Neurology

Volumn 61, Issue 9, 2003, Pages 1218-1221

  White, J R ^a,b   Walczak, T S ^a,b   Leppik, I E ^a,b   Rarick, J ^b   Tran, T ^a,b   Beniak, T E ^a   Matchinsky, D J ^c   Gumnit, R J ^a,b  

^a MINCEP Epilepsy Care   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c North Hennepin Community College   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETIRACETAM;

ADOLESCENT; ADULT; AGGRESSION; ARTICLE; BEHAVIOR DISORDER; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FOCAL EPILEPSY; GENERALIZED EPILEPSY; HALLUCINATION; HUMAN; INCIDENCE; IRRITABILITY; MAJOR CLINICAL STUDY; MALE; MAXIMUM PERMISSIBLE DOSE; MENTAL DISEASE; PRIORITY JOURNAL; PSYCHOSIS; RISK FACTOR; SIDE EFFECT;

EID: 0242578835     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.WNL.0000091865.46063.67     Document Type: Article

References (12)

1. White JR, Leppik IE, Rarick JO, et al. Characteristics of patients discontinuing levetiracetam: a case control study. Neurology 2002;58(suppl 3):A422.
2. Cereghino JJ, Biton V, Abou-Khalil B, et al. Levetiracetam for partial seizures. Results of a double-blind, randomized clinical trial. Neurology 2000;55:236-242.
3. Shorvon SD, Lowenthal A, Janz D, et al. Multicenter double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in patients with refractory partial seizures. Epilepsia 2000;41:1179-1186.
4. Ben-Menachem E, Falter U, European Levetiracetam Study Group. Efficacy and tolerability of levetiracetam 3000 mg/d in patients with refractory partial seizures: a multicenter, double-blind, responder-selected study evaluating monotherapy. Epilepsia 2000;41:1276-1283.
5. Physician's desk reference. 55th ed. Montvale, NJ: Medical Economics Co., 2001:3206-3209.
6. Harden C. Safety profile of levetiracetam. Epilepsia 2001;42(suppl 4): 36-39.
7. Bergey GK, Krauss GL, Lesser RS, Soham S. Tolerability of levetiracetam with high- and low-dose initiation. Neurology 2001;56(suppl 3): A335.
8. Asconope JJ, Gerardot JM, Gaston D. Behavioral changes associated with levetiracetam use in patients with epilepsy. Epilepsia 2001;42(suppl 7):299.
9. Sadek AH, Kanner A, Montouris G, Fix A, French J. Behavioral adverse events in patients receiving levetiracetam. Neurology 2002;58(suppl 3): A297.
10. Walczak TS, Leppik IE, D'Amelio M, et al. Incidence and risk factors in sudden unexpected death in epilepsy. A prospective cohort study. Neurology 2001;56:519-525.
11. Katzman R. Education and the prevalence of dementia and Alzheimer's disease. Neurology 1993;43:13-20.
12. Leppik IE. The place of levetiracetam in the treatment of epilepsy. Epilepsia 2001;42(suppl 4):44-45.