Study of Mimusops elengi bark in experimental gastric ulcers

Journal of Ethnopharmacology

Volumn 89, Issue 2-3, 2003, Pages 305-311

  Shah, Payal J ^a   Gandhi, Mitesh S ^a   Shah, Mamta B ^a   Goswami, Sunita S ^a   Santani, Devdas ^a  

^a L M COLLEGE OF PHARMACY   (India)

Author keywords

Anti ulcer activity; Gastric ulcers; Mimusops elengi

Indexed keywords

ACETIC ACID ETHYL ESTER; ANTIULCER AGENT; BUTANOL; GLYCOPROTEIN; METHANOL; MIMUSOPS ELENGI EXTRACT; MUCIN; PANTOPRAZOLE; PEPSIN A; PLANT EXTRACT; RANITIDINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BARK; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; ENZYME ACTIVITY; FRACTIONATION; MEDICINAL PLANT; MIMUSOPS ELENGI; MOUSE; NONHUMAN; PH MEASUREMENT; PYLORUS LIGATION; RAT; STOMACH ACID SECRETION; STOMACH INJURY; STOMACH PH; STOMACH ULCER; TOXICITY;

MIMUSOPS ELENGI;

EID: 0242552332     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2003.09.003     Document Type: Article

References (37)

1. Anichkov, S.V., Zabodskaya, I.S., Moreva, E.V., Korkhov, V.V., 1971. Effect of dihydroxyphenylalanine (DOPA) upon development of experimental neurogenic gastric ulcers. In: Pfeiffer, C.J. (Ed.), Peptic Ulcer, vol. 1. Munksgaard, Copenhagen, pp. 307-311.
2. Best R., Lewis A.L., Naseer N. The anti-ulcerogenic activity of the unripe plantain banana (Musa species). British Journal of Pharmacology. 82:1984;107-116.
3. Brodie D.A. The mechanism of gastric hyperacidity produced by pyloric ligation in the rat. American Journal of Digestive Diseases and Sciences. 111:1966;231-241.
4. Chiu P.J.S., Gerhart C., Brown A.D., Barnett A. Effects of gastric antisecretory cytoprotectant 2-methyl-8 phenylmethoxyimidazol{1,2-a}pyridine-3- acetonitrile (SCH 28080) on cysteamine, reserpine and stress ulcers in rats. Arzneimittel-Forschung/Drug Research. 34:1984;783-786.
5. Debnath P.K., Gode K.D., Govinda D.A.S., Sanyal A.K. Effect of propranolol on gastric secretion in albino rats. British Journal of Pharmacology. 51:1974;213-216.
6. Doll R., Langman M.J.S., Shawdon H.H. Treatment of gastric ulcer with carbenoxolone: antagonistic effect of spironolactone. Gut. 9:1968;42-45.
7. Garrick T., Buack S., Bass P. Gastric motility is a major factor in cold restraint-induced lesion formation in rats. American Journal of Physiology. 250:1986;G191-G199.
8. Gaskil H.V., Serinek K.R., Levine V.A. Effect of prostacyclin on mucosal blood flow. Surgery. 92:1982;220.
9. Goel R.K., Bhattacharya S.K. Gastroduodenal mucosal defence and mucosal protective agents. Indian Journal of Experimental Biology. 29:1991;701-714.
10. Guth P.H., Paulsen G., Nagata H. Histologic and microcirculatory changes in alcohol-induced lesion in the rat: effect of prostaglandin cytoprotection. Gastroenterology. 87:1984;1083-1090.
11. Guth P.H. Gastric blood flow in restraint stress. Digestive Diseases and Sciences. 17:1972;807-813.
12. Hart N.K., Johns S.R., Lamberton J.A. Alkaloids of Mimusops elengi bark. Australian Journal of Chemistry. 21:1968;1393-1395.
13. Hawk, P., Oser, B., Summerson, W., 1954. Gastric analysis. In: Practical Physiological Chemistry. Blakinston, Toronto, pp. 378-380.
14. Hawkey C.J., Ramtin D.S. Prostaglandin and gastrointestinal mucosa. Are they important in its function disease or treatment. Gastroenterology. 89:1985;1162.
15. Hayase M., Takeuchi K. Gastric acid secretion and lesion formation in rats under water-immersion stress. Digestive Diseases and Sciences. 31:1986;166-171.
16. Henke P.G., Ray A. The limbic brain, emotions and stress ulcers. Experimental and Clinical Gastroenterology. 1:1992;287-292.
17. Hogan D.L., Ainsworth M.A., Isbenberg J.I. Gastroduodenal bicarbonate secretion. Eliminate. Pharmacology and Therapeutics. 8:1994;475.
18. Kirtikar, K.R., Basu, B.D., 1935. Indian Medicinal Plants, 2nd ed., vol. 2. M/s Bishensingh Manendra Palsingh, New Connaught Place, Dehradun; M/s Periodical Experts, Vivek Vihar, Delhi, pp. 1494-1496.
19. Kitagawa H., Fujiwara M., Osumi Y. Effects of water-immersion stress on gastric secretion and mucosal blood flow in rats. Gastroenterology. 77:1979;298-302.
20. Lowry O.H., Rosenberg N.J., Farr A.L., Randall R.J. Protein measurement with folin reagent. Journal of Biological Chemistry. 193:1951;265-275.
21. Misra G., Mitra C.R. Constituents of fruit and seeds of Mimusops elengi. Phytochemistry. 6:1967;453.
22. Misra G., Mitra C.R. Constituents of leaves, hard wood and root of Mimusops elengi. Phytochemistry. 7:1968;501-502.
23. Morgan R.J., Nelson L.M., Russell R.I., Docherty C. The protective effect of deglycyrrhinized liquorice against aspirin and aspirin plus bile acid-induced gastric mucosal damage, and its influence on aspirin absorption in rats. Journal of Pharmacy and Pharmacology. 35:1983;605-607.
24. Mozsik G.Y., Kiss B., Javor J., Kraus M., Loth E. Effect of cholinesterase inhibitor treatment on the phosphorus and nucleic acid metabolism in the stomach wall. Pharmacology. 2:1969;45-49.
25. Ogle C.W., Cho C.H. Effects of sulphasalazine on stress ulceration and mast cell degranulation in rat stomach. European Journal of Pharmacology. 112:1985;285-286.
26. Pillai N.R., Santhakumari G. Effects of nimbidin on chronic gastro-duodenal ulcer models in experimental animals. Planta Medica. 50:1984;143-146.
27. Robert A. Cytoprotection by prostaglandins. Gastroenterology. 77:1979;761.
28. Robert A., Nezamis J.E., Lancaster C., Hanchar A.J. Cytoprotection by PGS in rats. Prevention of gastric necrosis produced by alcohol HCl, NaOH, hypotonic and thermal injury. Gastroenterology. 77:1979;433-443.
29. Salim A.S. The significance of removing oxygen derived free radicals in the treatment of acute and chronic duodenal ulceration in rats. Journal of Pharmacy and Pharmacology. 42:1990;64-67.
30. Sanyal A.K., Mitra P.K., Goel R.K. A modified method to estimate dissolved mucosubstances in gastric juice. Indian Journal of Experimental Biology. 21:1983;78-80.
31. Shay H., Komarov S.A., Fcis S.E., Meraze D., Gruenstein M., Siplet H. A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology. 5:1945;43-61.
32. Szabo S. Mechanisms of mucosal injury in the stomach and duodenum: time sequence analysis of morphologic, functional, biochemical and histochemical studies. Scandinavian Journal of Gastroenterology. 22:1987;21-28.
33. Szabo S., Trier J.S., Frankel P.W. Sulfhydral compounds may mediate gastric cytoprotection. Science. 214:1981;200-202.
34. Trease, E.G., Evans, W.E., 1978. Saponins and cardioactive drugs. In: Textbook of Pharmacognosy, 2nd ed. Bailiere Tindal, London, pp. 475-506.
35. Varsheny I.P., Badhwar G. Saponins and sapogenins of Mimusops elengi. Proceedings of National Academy of Sciences of the United States of America. 41:1972;21-23.
36. Venables C.W. Mucus Pepsin and peptic ulcer. Gut. 27:1986;233-238.
37. Yamahara J., Mochizuko M., Rong H.Q., Mats H., Fujimora H. Anti-ulcer effect of ginger in rats. Journal of Ethanopharmacology. 23:1998;299-304.