Infliximab for the treatment of severe steroid refractory acute graft-versus-host disease in three patients after allogeneic hematopoietic transplantation

Leukemia and Lymphoma

Volumn 44, Issue 12, 2003, Pages 2095-2097

  Yamane, Takahisa ^a   Yamamura, Ryousuke ^a   Aoyama, Yasutaka ^a   Nakamae, Hirohisa ^a   Hasegawa, Taro ^a   Sakamoto, Chikahiko ^a   Shibata, Hisako ^a   Terada, Yoshiki ^a   Koh, Genju ^a   Hino, Masayuki ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Allogeneic hematopoietic transplantation; GVHD; Infliximab; Steroid

Indexed keywords

ANTINEOPLASTIC AGENT; BUSULFAN; FLUDARABINE; INFLIXIMAB; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY;

ACUTE DISEASE; ACUTE LYMPHOCYTIC LEUKEMIA; ADOLESCENT; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CASE REPORT; DEATH; DIARRHEA; DISEASE SEVERITY; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG INDICATION; DRUG MEGADOSE; DRUG RESPONSE; ENCEPHALITIS; FEMALE; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HLA MATCHING; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; MALE; MYELODYSPLASTIC SYNDROME; NONHODGKIN LYMPHOMA; PERIPHERAL BLOOD STEM CELL; PRIORITY JOURNAL; PROGNOSIS; SKIN DISEASE; TIME; TREATMENT OUTCOME;

ACUTE DISEASE; ADOLESCENT; ADULT; ANTIBODIES, MONOCLONAL; FEMALE; GASTROINTESTINAL AGENTS; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; LYMPHOMA, NON-HODGKIN; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; PROGNOSIS; STEROIDS; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 0242550765     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/1042819031000123483     Document Type: Article

References (6)

1. Scallon, B.J., Moore, M.A., Trinh, H., Knight, D.M. and Ghrayeb, J. (1995) "Chimeric anti-TNF-alpha monoclonal antibody cA2 binds recombinant transmembrane TNF-alpha and activates immune effector functions", Cytokine 7, 251-259.
2. Present, D.H., Rutgeerts, P., Targan, S., Hanauer, S.B., Mayer, L., van Hogezand, R.A., Podolsky, D.K., Sands, B.E., Braakman, T., DeWoody, K.L., Schaible, T.F. and van Deventer, S.J. (1999) "Infliximab for the treatment of fistulas in patients with Crohn's disease", N. Engl. J. Med. 340, 1398-1405.
3. Choi, H.K., Seeger, J.D. and Kuntz, K.M. (2000) "A cost-effectiveness analysis of treatment options for patients with methotrexate-resistant rheumatoid arthritis", Arthritis Rheum. 43, 2316-2327.
4. Kobbe, G., Schneider, P., Rohr, U., Fenk, R., Neumann, F., Aivado, M., Dietze, L., Kronenwett, R., Hunerliturkoglu, A. and Haas, R. (2001) "Treatment of severe steroid refractory acute graft-versus-host disease with infliximab, a chimeric human/mouse antiTNFalpha antibody", Bone Marrow Transplant. 28, 47-49.
5. Couriel, D.R., Hicks, K., Giralt, S. and Champlin, R.E. (2000) "Role of tumor necrosis factor-alpha inhibition with inflixiMAB in cancer therapy and hematopoietic stem cell transplantation", Curr. Opin. Oncol. 12, 582-587.
6. Knight, D.M., Trinh, H., Le, J., Siegel, S., Shealy, D., McDonough, M., Scallon, B., Moore, M.A., Vilcek, J. and Daddona, P. (1993) "Construction and initial characterization of a mouse-human chimeric anti-TNF antibody", Mol. Immunol. 30, 1443-1453.