Autoimmune thrombocytopenia in chronic myeloid leukemia treated with interferon-alpha: Differential diagnosis and possible pathogenesis

Leukemia and Lymphoma

Volumn 44, Issue 12, 2003, Pages 2103-2108

  Herishanu, Yair ^a   Trestman, Svetlana ^a   Kirgner, Ilya ^a   Rachmani, Rodica ^a   Naparstek, Ella ^a  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

Author keywords

Autoimmune thrombocytopenia; Chronic myeloid leukemia; Interferon

Indexed keywords

ALPHA INTERFERON; DEXAMETHASONE; IMATINIB; PREDNISONE; RECOMBINANT ALPHA2A INTERFERON; RECOMBINANT ALPHA2B INTERFERON; STEROID;

ADULT; AGED; ARTICLE; AUTOIMMUNE DISEASE; CASE REPORT; CHRONIC MYELOID LEUKEMIA; DIFFERENTIAL DIAGNOSIS; DRUG DOSE REGIMEN; DRUG RESPONSE; DRUG WITHDRAWAL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER DYSFUNCTION; LONG TERM CARE; MEDICAL LITERATURE; PATHOGENESIS; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; STEROID THERAPY; THROMBOCYTOPENIA;

ADULT; AGED; AUTOIMMUNE DISEASES; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; INTERFERON-ALPHA; LEUKEMIA, MYELOID, CHRONIC; LEUKEMIA, MYELOID, PHILADELPHIA-POSITIVE; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; THROMBOCYTOPENIA;

EID: 0242550758     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/1042819031000123447     Document Type: Article

References (31)

1. Brassard, D.L., Grace, M.J. and Bordens, R.W. (2002) "Interferon-alpha as an immunotherapeutic protein", J. Leukoc. Biol. 7, 565-581.
2. Silver, R.T., Woolf, S.H., Hehlmann, R., Appelbaum, F.R., Anderson, J., Bennett, C., Goldman, J.M., Guilhot, F., Kantarjian, H.M., Lichtin, A.E., Talpaz, M. and Tura, S. (1999) "An evidence-based analysis of the effect of busulfan, hydroxyurea, interferon, and allogeneic bone marrow transplantation in treating the chronic phase of chronic myeloid leukemia: developed for the American Society of Hematology", Blood 94, 1517-1536.
3. Sawyers, C.L. (1999) "Chronic myeloid leukemia", N. Engl. J. Med. 340, 1330-1340.
4. Kirkwood, J.M., Bender, C., Agarwala, S., Tarhini, A., Shipe-Spotloe, J., Smelko, B., Donnelly, S. and Stover, L. (2002) "Mechanisms and management of toxicities associated with high-dose interferon alfa-2b therapy", J. Clin. Oncol. 20, 3703-3718.
5. Okanoue, T., Sakamoto, S., Itoh, Y., Minami, M., Yasui, K., Sakamoto, M., Nishioji, K., Katagishi, T., Nakagawa, Y., Tada, H., Sawa, Y., Mizuno, M., Kagawa, K. and Kashima, K. (1996) "Side effects of high-dose interferon therapy for chronic hepatitis C", J. Hepatol. 25, 283-291.
6. Raanani, P. and Ben-Bassat, I. (2002) "Immune-mediated complications during interferon therapy in hematological patients", Acta Haematol. 107, 133-144.
7. Sacchi, S., Kantarjian, H., O'Brien, S., Cohen, P.R., Pierce, S. and Talpaz, M. (1995) "Immune-mediated and unusual complications during interferon alfa therapy in chronic myelogenous leukemia", J. Clin. Oncol. 13, 2401-2407.
8. McLaughlin, P., Talpaz, M., Quesada, J.R., Saleem, A., Barlogie, B. and Gutterman, J.U. (1985) "Immune thrombocytopenia following alpha-interferon therapy in patients with cancer", JAMA 254, 1353-1354.
9. Cavanna, L., Vallisa, D., Berte, R., Buscarini, E., Fornari, F., Di Stasi, M., Civardi, G. and Buscarini, L. (1994) "Severe immune thrombocytopenic purpura relapse after alpha-interferon in chronic myeloid leukemia, successfully treated with cyclosporine", Am. J. Hematol. 47, 255-256.
10. Zuffa, E., Vianelli, N., Martinelli, G., Tazzari, P., Cavo, M. and Tura, S. (1996) "Autoimmune mediated thrombocytopenia associated with the use of interferon-alpha in chronic myeloid leukemia", Haematologica 8, 533-535.
11. Hoofnagle, J.H. (1991) "Thrombocytopenia during interferon alfa therapy", JAMA 266, 849.
12. Ganser, A., Carlo-Stella, C., Greher, J., Volkers, B. and Hoelzer, D. (1987) "Effect of recombinant interferons alpha and gamma on human bone marrow-derived megakaryocytic progenitor cells", Blood 70, 1173-1179.
13. Wang, Q., Miyakawa, Y., Fox, N. and Kaushansky, K. (2000) "Interferon-alpha directly represses megakaryopoiesis by inhibiting thrombopoietin-induced signaling through induction of SOCS-1", Blood 96, 2093-2099.
14. Davis, G.L., Esteban-Mur, R., Rustgi, V., Hoefs, J., Gordon, S.C., Trepo, C., Shiffman, M.L., Zeuzem, S., Craxi, A., Ling, M.H. and Albrecht, J. (1998) "Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. International Hepatitis Interventional Therapy Group", N. Engl. J. Med. 339, 1493-1499.
15. Toccaceli, F., Rosati, S., Scuderi, M., Iacomi, F., Picconi, R. and Laghi, V. (1998) "Leukocyte and platelet lowering by some interferon types during viral hepatitis treatment", Hepatogastroenterology 45, 1748-1752.
16. Peck-Radosavljevic, M., Wichlas, M., Pidlich, J., Sims, R, Meng, G., Zacherl, J., Garg, S., Datz, C., Gangl, A. and Ferenci, P. (1998) "Blunted thrombopoietin response to interferon alpha-induced thrombocytopenia during treatment for hepatitis C", Hepatology 28, 1424-1429.
17. Murakami, C.S., Zeller, K., Bodenheimer, H.C., Jr. and Lee, W.M. (1994) "Idiopathic thrombocytopenic purpura during interferon-alpha 2B treatment for chronic hepatitis", Am. J. Gastroenterol. 89, 2244-2245.
18. Shrestha, R., McKinley, C., Bilir, B.M. and Everson, G.T. (1995) "Possible idiopathic thrombocytopenic purpura associated with natural alpha interferon therapy for chronic hepatitis C infection", Am. J. Gastroenterol. 90, 1146-1147.
19. Tappero, G., Guerrasio, A., Gallo, M., Negro, F., Hadengue, A. and Angeli, A. (1996) "Interferon-induced lupoid thrombocytopenia in chronic hepatitis C", J. Hepatol. 24, 124.
20. Dourakis, S.P., Deutsch, M. and Hadziyannis, S.J. (1996) "Immune thrombocytopenia and alpha-interferon therapy", J. Hepatol. 25, 972-975.
21. Abdi, E.A., Brien, W. and Venner, P.M. (1986) "Auto-immune thrombocytopenia related to interferon therapy", Scand. J. Haematol. 36, 515-519.
22. Jimenez-Saenz, M., Rojas, M., Pinar, A., Salas, E,, Rebollo, J., Carmona, I., Herrerias-Esteban, J.M. and Herrerias-Gutierrez, J.M. (2000) "Sustained response to combination therapy in a patient with chronic hepatitis C and thrombocytopenia secondary to alpha-interferon", J. Gastroenterol. Hepatol. 15, 567-569.
23. Semple, J.W. (1998) "Immunobiology of T helper cells and antigen-presenting cells in autoimmune thrombocytopenic purpura (ITP ", Acta Paediatr. Suppl. 424, 41-45.
24. Nagamine, T., Ohtuka, T., Takehara, K., Arai, T., Takagi, H. and Mori, M. (1996) "Thrombocytopenia associated with hepatitis C viral infection", J. Hepatol. 24, 135-140.
25. Gresele, P., Clive, P.P., Fuster, V. and Vermylen, J. (2002) Platelets in Thrombotic and Non-thrombotic Disorders; Pathophysiology, Pharmacology and Therapeutics (Cambridge University Press, United Kingdom), pp 546-547.
26. Rachmani, R., Avigdor, A., Youkla, M., Raanani, P., Zilber, M., Ravid, M. and Ben-Bassat, I. (1998) "Thrombotic thrombocytopenic purpura complicating chronic myelogenous leukemia treated with interferon-alpha. A report oftwo successfully treated patients", Acta Haematol. 100, 204-206.
27. Ravandi-Kashani, F., Cortes, J., Talpaz, M. and Kantarjian, H.M. (1999) "Thrombotic microangiopathy associated with interferon therapy for patients with chronic myelogenous leukemia: coincidence or true side effect?", Cancer 85, 2583-2588.
28. Iyoda, K., Kato, M., Nakagawa, T., Kakiuchi, Y., Sugiyasu, Y., Fujii, E., Fujimoto, K., Michida, T., Kaneko, A., Hayashi, N., Yamamoto, K., Kurosawa, K., Ikeda, M. and Masuzawa, M. (1998) "Thrombotic thrombocytopenic purpura developed suddenly during interferon treatment for chronic hepatitis C", J. Gastroenterol. 33, 588-592.
29. Lacotte, L., Thierry, A., Delwail, V., Dreyfus, B. and Guilhot, F. (2000) "Thrombotic thrombocytopenic purpura during interferon alpha treatment for chronic myelogenous leukemia", Acta Haematol. 102, 160-162.
30. Drachman, J.G., Rojnuckarin, P. and Kaushansky, K. (1999) "Thrombopoietin signal transduction: studies from cell lines and primary cells", Methods 17, 238-249.
31. Kaushansky, K. and Drachman, J.G. (2002) "The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production", Oncogene 21, 3359-3367.