Novel Synthetic Approach to 6,7-Dihydro-5H-imidazo[1,5-a]-pyrazin-8-ones

Organic Letters

Volumn 5, Issue 21, 2003, Pages 3907-3909

  Gopalsamy, Ariamala ^a   Shi, Mengxiao ^a  

^a WYETH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID; ESTER DERIVATIVE; MELDRUM ACID; PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; CYCLIZATION; METHODOLOGY; MOLECULAR INTERACTION; SUBSTITUTION REACTION; SYNTHESIS;

EID: 0242543743     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol035455i     Document Type: Article

References (17)

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16. (a) Solution-phase parallel synthesis was carried out in 8 mL vials using J-Kem blocks with heating and cooling capabilities.
17. (b) All compounds were purified by HPLC. A Gilson HPLC instrument with Unipoint software was used. Column: Phenomenex C18 Luna 21.6 x 60 mm, 5 μM. Solvent A: water (0.02% TFA buffer). Solvent B: acetonitrile (0.02% TFA buffer). Solvent gradient: time 0 min (5% B), 2.5 min (5% B), 12 min (95% B), hold 3 min (95% B). Flow rate: 22.5 mL/min. Detection: 215 and 254 nm. Reported yields are isolated yields.