Effectiveness and mechanism of action of desmopressin in the treatment of copper intrauterine device-related menorrhagia: A pilot study

Human Reproduction

Volumn 18, Issue 11, 2003, Pages 2319-2322

  Mercorio, F ^a   De Simone, R ^a   Di Carlo, C ^a   Bifulco, G ^a   Tessitore, G ^a   Sardo, A Di Spiezio ^a   Nappi, C ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Desmopressin; IUD related menorrhagia; Uterine artery resistance

Indexed keywords

COPPER; DESMOPRESSIN; MEFENAMIC ACID; VASOPRESSIN;

ADULT; ARTERY RESISTANCE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; FEMALE; HEMODYNAMIC PARAMETERS; HEMOSTASIS; HUMAN; INTRAUTERINE CONTRACEPTIVE DEVICE; MENORRHAGIA; MENSTRUATION; PROSPECTIVE STUDY; PULSATILE FLOW; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TRANSVAGINAL ECHOGRAPHY; UTERINE ARTERY; UTERUS BLOOD FLOW;

EID: 0242522143     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/deg449     Document Type: Article

References (20)

1. Bergsjo, P. (1992) Update on the intrauterine contraceptive device. Acta Obstet. Gynecol. Scand., 71, 163-165.
2. Cattaneo, M., Moia, M., Della Valle, P., Castellana, P. and Mannucci, P.M. (1989) DDAVP shortens the prolonged bleeding time of patients with severe von Willebrand disease treated with cryoprecipitate: Evidence for a mechanism of action independent of released von Willebrand factor. Blood, 74, 1972-1975.
3. Edlund, M., Blomback, M. and Fried, G. (2002) Desmopressin in the treatment of menorrhagia in women with no common coagulation factor deficiency but with prolonged bleeding time. Blood Coag. Fibrinol., 13, 225-231.
4. Frederick, J., Fletcher, H., Simeon, D., Mullings, A. and Hardie, M. (1994) Intramyometrial vasopressin as a haemostatic agent during myomectomy. Br. J. Obstet. Gynecol., 101, 435-437.
5. Guillebaud, J., Anderson, A.B.M. and Turnball, A.C. (1978) Reduction by mefenamic acid of increased menstrual blood loss associated with intrauterine contraception. Br. J. Obstet. Gynecol., 85, 53.
6. Higham, J.M., O'Brien, P.M.S. and Shaw, R.W. (1990) Assessment of menstrual blood loss using a pictorial chart. Br. J. Obstet. Gynaecol., 97, 734-739.
7. Hillier, K. and Kasonde, J.M. (1976) Prostaglandin E and F concentrations in human endometrium after insertion of intrauterine contraceptive devices. Lancet, 1, 15-16.
8. Janssen, C.A.H., Sholten, P.C. and Heintz, A.P.M. (1995) A simple visual assessment technique to discriminate between menorrhagia and normal menstrual blood loss. Obstet. Gynecol., 85, 977-982.
9. Larsson, B., Liedholm, P., Sjoberg, N.O and Asted, B. (1974) Increased fibrinolytic activity in the endometrium of patients using copper IUD. Contraception, 9, 531.
10. Lethagen, S. (1999) Desmopressin in the treatment of women's bleeding disorders. Haemophilia, 5, 233-237.
11. Lethagen, S., Harris, A.S., Sjorin, E. and Nilsson, I.M. (1987) Intranasal and intravenous administration of desmopressin: Effect on FVIII/vWF pharmacokinetics and reproducibility. Thromb. Haemost., 58, 1033-1036.
12. Lethagen, S., Rugarn, P., Aberg, M. and Nilsson, I.M. (1990) Effects of desmopressin acetate (DDAVP) and dextran on hemostatic and thromboprophylactic mechanisms. Acta Chir. Scand., 156, 597-602.
13. Mannucci, P.M. (1998) Hemostatic drugs. N. Engl. J. Med., 339, 245.
14. Momtaz, M., Zayed, M., Rashid, K. and Idriss, O. (1994) Doppler study of the uterine artery in patients using an intrauterine contraceptive device. Ultrasound Obstet. Gynecol., 4, 231-234.
15. Moncada, S., Gtyglewski, R.J., Bunting, S. and Vane, I.R. (1976) An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature, 262, 663.
16. Reid, P.C., Coker, A. and Coltart, R. (2000) Assessment of menstrual blood loss using a pictorial chart: A validation study. Br. J. Obstet. Gynecol., 107, 320-322.
17. Rybo, G., Nilsson, S., Sikstrom, B. and Nygren, K.G. (1981) Naproxen in menorrhagia. Lancet, 1, 608-609.
18. 2) in excessive menstrual bleeding. Lancet, 1, 522-524.
19. Towsend, D.E. (1991) Vasopressin pack for treatment of bleeding after myoma resection. Am. J. Obstet. Gynecol., 165, 1405-1407.
20. Zaidi, J., Jurkovic, D., Campbell, S., Okokou, E. and Tan, S.L. (1995) Circadian variation in uterine blood flow during the follicular phase of menstrual cycle. Ultrasound Obstet. Gynecol., 5, 406-411.