Changes in cerebral interstitial glycerol concentration in head-injured patients; correlation with secondary events

Intensive Care Medicine

Volumn 29, Issue 10, 2003, Pages 1825-1828

  Peerdeman, Saskia M ^a   Girbes, Armand R J ^a   Polderman, Kees H ^a   Vandertop, W Peter ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Glycerol; Head injury; Microdialysis; Outcome

Indexed keywords

GLYCEROL;

ADULT; AGED; ANASTOMOSIS; ARTERIAL OXYGEN SATURATION; ARTICLE; BLOOD PRESSURE; BRAIN INJURY; BRAIN LEVEL; BRAIN PERFUSION; CATHETER; CLINICAL ARTICLE; CORRELATION ANALYSIS; DIAGNOSTIC VALUE; EARLY DIAGNOSIS; FEMALE; GLASGOW COMA SCALE; HEAD INJURY; HUMAN; INTENSIVE CARE UNIT; INTRACRANIAL PRESSURE; MALE; MICRODIALYSIS; PERFUSION PRESSURE;

ADOLESCENT; ADULT; AGED; BRAIN; BRAIN INJURIES; FEMALE; GLYCEROL; HUMANS; INJURY SEVERITY SCORE; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; TIME FACTORS;

EID: 0242509180     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-003-1850-8     Document Type: Article

References (16)

1. Marklund N, Salci K, Lewen A, Hillered L (1997) Glycerol as a marker for post-traumatic membrane phospholipid degradation in rat brain. Neuroreport 8:1457-1461
2. Siesjö BK, Katsura K (1992) Ischemic brain damage: focus on lipids and lipid mediators. In: Bazan NGTG, Murphy M (eds) Neurobiology of essential fatty acids. Plenum Press, New York, pp 41-56
3. Bazan NG Jr, Rakowski H (1970) Increased levels of brain free fatty acids after electroconvulsive shock. Life Sci 9:501-507
4. Anderson DK, Hall ED (1994) Lipid hydrolysis and free radical formation on central nervous system trauma. In: Salzman SK, Faden AI (eds) The neurobiology of central nervous system trauma. Oxford University Press, New York Oxford, pp 131-138
5. Chesnut RM, Marshall LF, Klauber MR, Blunt BA, Baldwin N, Eisenberg HM, Jane JA, Marmarou A, Foulkes MA (1993) The role of secondary brain injury in determining outcome from severe head injury. J Trauma 34:216-222
6. Peerdeman SM, Girbes AR, Vandertop WP (2000) Cerebral microdialysis as a new tool for neurometabolic monitoring. Intensive Care Med 26:662-669
7. Hillered L, Persson L, Ponten U, Ungerstedt U (1990) Neurometabolic monitoring of the ischaemic human brain using microdialysis. Acta Neurochir (Wien) 102:91-97
8. Schulz MK, Wang LP, Tange M, Bjerre P (2000) Cerebral microdialysis monitoring: determination of normal and ischemic cerebral metabolisms in patients with aneurysmal subarachnoid hemorrhage. J Neurosurg 93:808-814
9. Nilsson OG, Brandt L, Ungerstedt U, Saveland H (1999) Bedside detection of brain ischemia using intracerebral microdialysis: subarachnoid hemorrhage and delayed ischemic deterioration. Neurosurgery 45:1176-1184
10. Hillered L, Valtysson J, Enblad P, Persson L (1998) Interstitial glycerol as a marker for membrane phospholipid degradation in the acutely injured human brain. J Neurol Neurosurg Psychiatry 64:486-491
11. Polderman KH, Peerdeman SM, Girbes AR (2001) Hypophosphatemia and hypomagnesemia induced by cooling in patients with severe head injury. J Neurosurg 94:697-705
12. Polderman KH, Tjong Tjin JR, Peerdeman SM, Vandertop WP, Girbes AR (2002) Effects of therapeutic hypothermia on intracranial pressure and outcome in patients with severe head injury. Intensive Care Med 28:1563-1573
13. Reinstrup P, Stahl N, Mellergard P, Uski T, Ungerstedt U, Nordstrom CH (2000) Intracerebral microdialysis in clinical practice: baseline values for chemical markers during wakefulness, anesthesia and neurosurgery. Neurosurgery 47:701-709
14. Sarrafzadeh AS, Sakowitz OW, Kiening KL, Benndorf G, Lanksch WR, Unterberg AW (2002) Bedside microdialysis: a tool to monitor cerebral metabolism in subarachnoid hemorrhage patients? Crit Care Med 30:1062-1070
15. Chesnut RM, Marshall SB, Piek J, Blunt BA, Klauber MR, Marshall LF (1993) Early and late systemic hypotension as a frequent and fundamental source of cerebral ischemia following severe brain injury in the Traumatic Coma Data Bank. Acta Neurochir Suppl (Wien) 59:121-125
16. Frykholm P, Hillered L, Langstrom B, Persson L, Valtysson J, Watanabe Y, Enblad P (2001) Increase of interstitial glycerol reflects the degree of ischaemic brain damage: a PET and microdialysis study in a middle cerebral artery occlusion-reperfusion primate model. J Neurol Neurosurg Psychiatry 71:455-461