Par j 1 and Par j 2, the major allergens from Parietaria judaica pollen, have similar immunoglobulin E epitopes

Clinical and Experimental Allergy

Volumn 33, Issue 4, 2003, Pages 518-524

  Asturias, J A ^a   Gomez Bayon N ^a   Eseverri, J L ^b   Martinez A ^a  

^a Research and Development Department   (Spain)

^b HOSPITAL MATERNO INFANTIL VALL D HEBRON   (Spain)

Author keywords

3 D structure; Epitope; Major allergens; Parietaria judaica; Pollen allergy; SPOT membrane

Indexed keywords

ALLERGEN; CYSTEINE; EPITOPE; IMMUNOGLOBULIN E; LIPID TRANSFER PROTEIN; PROTEIN PAR J 1; PROTEIN PAR J 2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CLINICAL ARTICLE; CRYSTAL STRUCTURE; DISULFIDE BOND; GENE IDENTIFICATION; HUMAN; PARIETARIA JUDAICA; POLLEN; POLLEN ALLERGY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; SEQUENCE HOMOLOGY; SOUTHERN EUROPE; THREE DIMENSIONAL IMAGING;

ALLERGENS; BINDING SITES; EPITOPES; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOGLOBULIN E; MOLECULAR SEQUENCE DATA; PARIETARIA; PEPTIDE MAPPING; PLANT PROTEINS; POLLEN; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY;

EID: 0242499979     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2003.01631.x     Document Type: Article

References (37)

1. Miyamoto T. Increased prevalence of pollen allergy in Japan. In: Godard P, Bousquet J, Michel FB eds. Advances in Allergology and Clinical Immunology. Cornforth, UK: The Parthenon Publishing Group, 1992:343-7.
2. Bousquet J, Lockey R, Malling HJ. Allergen immunotherapy: therapeutic vaccines for allergic diseases. Allergy 1998; 53:1-42.
3. Aalberse RC. Structural biology of allergens. J Allergy Clin Immunol 2000; 106:228-38.
4. Burks AW, Shin D, Cockrell G, Stanley JS, Helm RM, Bannon GA. Mapping and mutational analysis of the IgE-binding epitopes on Ara h 1, a legume vicilin protein and a major allergen in peanut hypersensitivity. Eur J Biochem 1997; 245:334-9.
5. Chatchatee P, Järvinen KM, Bardina L, Vila L, Beyer K, Sampson HA. Identification of IgE and IgG binding epitopes on β- and k-casein in cow's milk allergic patients. Clin Exp Allergy 2001; 31:1256-62.
6. Robotham JM, Teuber SS, Sathe SK, Roux KH. Linear IgE epitope mapping of the English walnut (Juglans regia) major food allergen, Jug R 1 J. Allergy Clin Immunol 2002; 109:143-9.
7. Schramm G, Bufe A, Petersen A et al. Discontinuous IgE-binding epitopes contain multiple continuous epitope regions: results of an epitope mapping on recombinant Hol 1 5, a major allergen from velvet grass pollen. Clin Exp Allergy 2001; 31:331-41.
8. Beezhold DH, Kostyal DA, Sussman GL. IgE epitope analysis of the hevein preprotein; a major latex allergen. Clin Exp Immunol 1997; 108:114-21.
9. Banerjee B, Wang XD, Kelly KJ, Fink JN, Sussman GL, Kurup VP. IgE from latex-allergic patients binds to cloned and expressed B cell epitopes of prohevein. J Immunol 1997; 159:5724-32.
10. Beezhold DH, Hickey VL, Slater JE, Sussman GL. Human IgE-binding epitopes of the latex allergen Hev b 5. J Allergy Clin Immunol 1999; 103:1166-72.
11. Stanley JS, King N, Burks AW et al. Identification and mutational analysis of the immunodominant IgE binding epitopes of the major peanut allergen Ara h 2. Arch Biochem Biophys 1997; 342:244-53.
12. Masullo M, Mariotta S, Torrelli L, Graziani E, Anticoli S, Mannino F. Respiratory allergy to Parietaria in 348 subjects. Allergol Immunopathol 1996; 24:3-6.
13. Duro G, Colombo P, Costa MA et al. cDNA cloning, sequence analysis and allergological characterization of Par j 2.0101, a new major allergen of the Parietaria judaica pollen. FEBS Lett 1996; 399:295-8.
14. Duro G, Colombo P, Costa MA et al. Isolation and characterization of two cDNA clones coding for isoforms of the Parietaria judaica major allergen Par j 1.0101. Int Arch Allergy Immunol 1997; 112:348-55.
15. Costa MA, Colombo P, Izzo V et al. cDNA cloning expression and primary structure of Par j I, a major allergen of Parietaria judaica pollen. FEBS Lett 1994; 341:182-6.
16. Colombo P, Kennedy D, Ramsdale T et al. Identification of an immunodominant IgE epitope of the Parietaria judaica major allergen. J Immunol 1998; 160:2780-5.
17. Guex N, Peitsch MC. Swiss-model and the swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 1997; 18:2714-23.
18. Han GW, Lee JY, Song HK et al. Structural basis of non-specific lipid binding in maize, lipid transfer protein complexes revealed by high-resolution X-ray crystallography. J Mol Biol 2001; 308:263-78.
19. Rost B, Sander C. Conservation and prediction of solvent accessibility in protein families. Proteins 1994; 20:216-26.
20. Ferreira F, Ebner C, Kramer B et al. Modulation of IgE reactivity of allergens by site-directed mutagenesis: potential use of hypoallergenic variants for immunotherapy. FASEB J 1998; 12:231-42.
21. Vrtala S, Hirtenlehner K, Vangelista L et al. Conversion of the major birch pollen allergen, Bet v 1, into two non-anaphylactic T cell epitope - containing fragments. J Clin Invest 1997; 99:1673-81.
22. Takai T, Yokota T, Yasue M et al. Engineering of the major house dust mite allergen Der f 2 for allergen-specific immunotherapy. Nat Biotechnol 1997; 15:754-8.
23. Piao-King T, Sui YJ, Monsalve RI, Kagey-Sobotka A, Lichtenstein LM, Spangfort MD. Recombinant allergens with reduced allergenicity but retaining immunogenicity of the natural allergens: hybrids of yellow jacket and paper wasp venom allergen antigen 5s. J Immunol 2001; 166:6057-65.
24. Bonura A, Amoroso S, Locorotondo G et al. Hypoallergenic variants of the Parietaria judaica major allergen Par j 1: a member of the non-specific lipid transfer protein plant family. Int Arch Allergy Immunol 2001; 126:32-40.
25. Ball T, Vrtala S, Sperr WR et al. Isolation of an immunodominant IgE hapten from an epitope expression cDNA library. J Biol Chem 1994; 269:28323-8.
26. Schramm G, Kahlert H, Suck R et al. 'Allergen engineering': variants of the timothy grass pollen allergen Phl p 5b with reduced IgE-binding capacity but conserved T cell reactivity. J Immunol 1999; 162:2406-14.
27. Fedorov AA, Ball T, Mahoney NM, Valenta R, Almo SC. The molecular basis for allergen cross-reactivity. Crystal structure and IgE-epitope mapping of birch pollen profilin. Structure 1997; 5:33-45.
28. Slater JE, Paupore EJ, O'Hehir RE. Murine B-cel and T-cell epitopes of the allergen Hev b 5 from natural rubber latex. Mol Immunol 1999; 36:135-43.
29. Costa MA, Duro G, Izzo V et al. The IgE-binding epitopes of rPar j 2, a major allergen of Parietaria judaica pollen, are heterogenously recognized among allergic subjects. Allergy 2000; 55:246-50.
30. De Palma R, Wu S, Sallusto F et al. Use of antagonist peptides to inhibit in vitro T cell responses to Par j 1, the major allergen of Parietaria judaica pollen. J Immunol 1999; 162:1982-7.
31. King TP, Lu G, Agosto H. Antibody responses to bee melittin (Api m 4) and hornet antigen 5 (Dol m 5) in mice treated with the dominant T-cell epitope peptides. J Allergy Clin Immunol 1998; 101:397-403.
32. Wu B, Toussaint G, Vander Elst L, Granier C, Jacquemin MG, Saint-Remy JM. Major T cell epitope-containing peptides can elicit strong antibody responses. Eur J Immunol 2000; 30:291-9.
33. Helm RM, Cockrell G, Connaughton C et al. Mutational analysis of the IgE-binding eipitopes of P34/Gly m Bd 30K. J Allergy Clin Immunol 2000; 105:378-84.
34. Rabjohn P, West CM, Connaughton C et al. Modification of peanut allergen Ara h 3: effects on IgE binding and T cell stimulation. Int Arch Allergy Immunol 2002; 128:15-23.
35. Beezhold DH, Hickey VL, Sussman GL. Mutational analysis of IgE epitopes in the latex allergen Hev b 5. J Allergy Clin Immunol 2001; 107:1069-76.
36. Soman KV, Midoro-Horiuti T, Ferreon JC et al. Homology modeling and characterization of IgE binding epitopes of mountain cedar allergen Jun a 3. Biophys J 2000; 79:1601-9.
37. Focke M, Mahler V, Ball T et al. Nonanaphylactic synthetic peptides derived from B cell epitopes of the major grass pollen allergen, Phl p 1, for allergy vaccination. FASEB J 2001; 15:2042-4.