Hypertrophy of Vascularized Bone Isograft in Rats Treated with Cyclosporine A

Calcified Tissue International

Volumn 73, Issue 4, 2003, Pages 393-399

  Tsubone, T ^a   Shigetomi, M ^a   Ihara, K ^a   Ikeda, K ^a   Merida, L ^a   Ohno, T ^a   Sugiyama, T ^a   Kawai, S ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cyclosporine A; Hypertrophy; Large bone defect; Transplantation; Vascularized bone graft

Indexed keywords

CYCLOSPORIN A; DEOXYPYRIDINOLINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEFECT; BONE DENSITY; BONE GRAFT; BONE MINERAL; BONE MINERALIZATION; BONE RADIOGRAPHY; BONE REMODELING; BONE STRENGTH; BONE TRANSPLANTATION; BONE TURNOVER; CONTROLLED STUDY; DRUG EFFECT; HYPERTROPHY; IMMUNOSUPPRESSIVE TREATMENT; MALE; NONHUMAN; OSTEOLYSIS; PRIORITY JOURNAL; RAT; URINALYSIS; VASCULARIZATION; X RAY ANALYSIS;

AMINO ACIDS; ANIMALS; BIOLOGICAL MARKERS; BODY WEIGHT; BONE DENSITY; BONE TRANSPLANTATION; CYCLOSPORINE; DISEASE MODELS, ANIMAL; FIBULA; GRAFT SURVIVAL; HYPERTROPHY; IMMUNOCOMPROMISED HOST; IMMUNOSUPPRESSIVE AGENTS; MALE; OSTEOGENESIS; RATS; RATS, INBRED LEW; TIBIA; TOMOGRAPHY, X-RAY COMPUTED; TRANSPLANTATION, ISOGENEIC;

EID: 0242493694     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-002-2147-6     Document Type: Article

References (24)

1. Epstein S (1996) Post-transplantation bone disease: the role of immunosuppressive agents and the skeleton. J Bone Miner Res 11:1-7
2. Rodino MA, Shane E (1998) Osteoporosis after organ transplantation. Am J Med 104:459-469
3. Ramsey-Goldman R, Dunn JE, Dunlop DD, Stuart FP, Abecassis MM, Kaufman DB, Langman CB, Salinger MH, Sprague SM (1999) Increased risk of fracture in patients receiving solid organ transplants. J Bone Miner Res 14:456-463
4. Leidig-Bruckner G, Hosch S, Dodidou P, et al. (2001) Frequency and predictors of osteoporotic fractures after cardiac or liver transplantation: a follow-up study. Lancet 357:342-347
5. Delmas PD (2001) Osteoporosis in patients with organ transplants: a neglected problem. Lancet 357:325-326
6. Movsowitz C, Epstein S, Fallon M, Ismail F, Thomas S (1988) Cyclosporin-A in vivo produces severe osteopenia in the rat: effect of dose and duration of administration. Endocrinology 123:2571-2577
7. Buchinsky FJ, Ma Y, Mann GN, Rucinski B, Bryer HP, Romero DF, Jee WS, Epstein S (1996) T lymphocytes play a critical role in the development of cyclosporin A-induced osteopenia. Endocrinology 137:2278-2285
8. Goodman GR, Dissanayake IR, Bowman AR, Pun S, Ma Y, Jee WS, Bryer HP, Epstein S (2001) Transforming growth factor-β administration modifies cyclosporine A-induced bone loss. Bone 28:583-588
9. Epstein S, Dissanayake IR, Goodman GR, Bowman AR, Zhou H, Ma Y, Jee WS (2001) Effect of the interaction of parathyroid hormone and cyclosporine A on bone mineral metabolism in the rat. Calcif Tissue Int 68:240-247
10. Orcel P, Bielakoff J, Modrowski D, Miravet L, de Vernejoul MC (1989) Cyclosporin A induces in vivo inhibition of resorption and stimulation of formation in rat bone. J Bone Miner Res 4:387-391
11. del Pozo E, Graeber M, Elford P, Payne T (1990) Regression of bone and cartilage loss in adjuvant arthritic rats after treatment with cyclosporin A. Arthritis Rheum 33:247-252
12. Han CS, Wood MB, Bishop AT, Cooney III WP (1992) Vascularized bone transfer. J Bone Joint Surg Am 74:1441-1449
13. Wei FC, El-Gammal TA, Lin CH, Ueng WN (1997) Free fibula osteoseptocutaneous graft for reconstruction of segmental femoral shaft defects. J Trauma 43:784-792
14. Duffy GP, Wood MB, Rock MG, Sim FH (2000) Vascularized free fibular transfer combined with autografting for the management of fracture nonunions associated with radiation therapy. J Bone Joint Surg Am 82:544-554
15. Shin AY, Bishop AT (2001) Vascular anatomy of the distal radius: implications for vascularized bone grafts. Clin Orthop 383:60-73
16. Doi K, Akino T, Shigetomi M, Muramatsu K, Kawai S (1994) Vascularized bone allografts: review of current concepts. Microsurgery 15:831-841
17. Doi K, Kawai S, Shigetomi M (1996) Congenital tibial pseudoarthrosis treated with vascularised bone allograft. Lancet 347:970-971
18. Hofmann GO, Kirschner MH, Wagner FD, Brauns L, Gonschorek O, Bühren V (1998) Allogeneic vascularized transplantation of human femoral diaphyses and total knee joints: first clinical experiences. Transplant Proc 30:2754-2761
19. Hofmann GO, Kirschner MH (2000) Clinical experience in allogeneic vascularized bone and joint allografting. Microsurgery 20:375-383
20. 3, on bone reconstruction by vascularized bone allograft. Bone 30:422-427
21. Ohno T, Shigetomi M, Ihara K, Ikeda K, Tsubone T, Matsunaga T, Sugiyama T, Kawai S (2003) Effects of cerivastatin on vascularized allogenic bone transplantation in rats treated with cyclosporine A. Calcif Tissue Int 72:50-56
22. Shigetomi M, Doi K, Kuwata N, Muramatsu K, Yamamoto H, Kawai S (1994) Experimental study on vascularized bone allografts for reconstruction of massive bone defects. Microsurgery 15:663-670
23. de Boer HH, Wood MB (1989) Bone changes in the vascularised fibular graft. J Bone Joint Surg Br 71:374-378
24. Tamai S (1995) Experimental vascularized bone transplantations. Microsurgery 16:179-185