Co-fermentation of glucose and citrate by Lactococcus lactis diacetylactis: Quantification of the relative metabolic rates by isotopic analysis at natural abundance

Applied Microbiology and Biotechnology

Volumn 62, Issue 5-6, 2003, Pages 489-497

  Goupry, S ^a   Gentil, E ^a   Akoka, S ^a   Robins, R J ^a  

^a Centre National de la Recherche Scientifique   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 BUTANEDIONE; ACETOIN; CARBON; CARBON 13; CITRIC ACID; GLUCOSE; LACTIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; PYRUVIC ACID;

BIOTECHNOLOGY; FERMENTATION; GLUCOSE;

ARTICLE; BACTERIAL GROWTH; BACTERIAL METABOLISM; ENVIRONMENTAL FACTOR; FERMENTATION; LACTOCOCCUS LACTIS; METABOLIC RATE; NONHUMAN; PH; TEMPERATURE;

ACETATES; ACETOIN; CITRIC ACID; DIACETYL; FERMENTATION; GLUCOSE; HYDROGEN-ION CONCENTRATION; LACTIC ACID; LACTOCOCCUS LACTIS; PYRUVIC ACID; TEMPERATURE;

BACTERIA (MICROORGANISMS); LACTOCOCCUS; LACTOCOCCUS LACTIS; LACTOCOCCUS LACTIS SUBSP. LACTIS; LACTOCOCCUS LACTIS SUBSP. LACTIS BV. DIACETYLACTIS; POSIBACTERIA; STREPTOCOCCUS;

EID: 0242490878     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-003-1313-8     Document Type: Article

References (36)

1. Bandell M, Lhotte ME, Marty-Teysset C, Veyrat A, Prevost H, Dartois V, Diviès C, Konings WN, Lolkema JS (1998) Mechanism of the citrate transporters in carbohydrate and citrate cometabolism in Lactococcus and Leuconostoc species. Appl Environ Microbiol 64:1594-1600
2. Bassit N, Boquien CY, Picque D, Corrieu G (1993) Effect of initial oxygen concentration on diacetyl and acetoin production by Lactococcus lactis subsp. lactis biovar. diacetylactis. Appl Environ Microbiol 59:1833-1897
3. Bassit N, Boquien CY, Picque D, Corrieu G (1995) Effect of temperature on diacetyl and acetoin production by Lactococcus lactis subsp. lactis biovar. diacetylactis CNRZ 483. J Dairy Res 62:123-129
4. Boumerdassi H, Desmazeaud M, Monnet C, Boquein C, Corrieu G (1996) Improvement of diacetyl production by Lactococcus lactis ssp. lactis CNRZ 483 through oxygen control. J Dairy Res 79:775-781
5. Boumerdassi H, Monnet C, Desmazeaud M, Corrieu G (1997) Effect of citrate on production of diacetyl and acetoin by Lactococcus lactis ssp. lactis CNRZ 483 cultivated in the presence of oxygen. J Dairy Res 80:634-639
6. Brand WA (1996) High precision isotope ratio monitoring techniques in mass spectrometry. J Mass Spectrom 31:225-235
7. Cachon R, Diviès C (1993) Kinetics of lactate fermentation and citrate bioconversion by Lactococcus lactis ssp. lactis in batch culture. J Appl Bacteriol 75:387-392
8. Cachon R, Diviès C (1994) Generalized model of the effect of pH on lactate fermentation and bioconversion in Lactococcus lactis ssp. lactis biovar. diacetylactis. Appl Microbiol Biotechnol 41:694-699
9. Cachon R, Daniel S, Diviès C (1995) Proton-dependent kinetics of citrate uptake in growing cells of Lactococcus lactis subsp. lactis bv. diacetylactis. FEMS Microbiol Lett 131:319-323
10. Cocaign-Bousquet M, Garrigues C, Loubière P, Lindley ND (1996) Physiology of pyruvate metabolism in Lactococcus lactis. Antonie Van Leeuvenhoek 70:253-267
11. Cogan TM (1981) Constitutive nature of the enzymes of citrate metabolism in Streptococcus lactis subsp. diacetylactis. J Dairy Res 48:480-495
12. Cogan TM (1982) Acetoin production and citrate metabolism in Streptococcus lactis subsp. diacetylactis. Irish J Food Sci Technol 6:69-78
13. Curic M, Stuer-Lauridsen B, Renault P, Nilsson D (1999). A general method for selection of alpha-acetolactate decarboxylase-deficient Lactococcus lactis mutants to improve diacetyl formation. Appl Environ Microbiol 65:1202-1206
14. Duggleby RG, Northrop DB (1989) The expression of kinetic isotope effects during the time course of enzyme-catalysed reactions. Bioorg Chem 17:177-193
15. García-Quintáns N, Magni C, Mendoza D de, Lopez P (1998) The citrate transport system of Lactococcus lactis subsp. lactis biovar. diacetylactis is induced by acid stress. Appl Environ Microbiol 64:850-1600
16. Goupil N, Corthier G, Ehrlich S, Renault P (1996) Imbalance of leucine flux in Lactococcus lactis and its use for the isolation of diacetyl- overproducing strains. Appl Environ Microbiol 62:2636-4498
17. Goupry S, Croguennec T, Gentil E, Robins RJ (2000a) Metabolic flux in glucose/citrate co-fermentation by lactic acid bacteria as measured by isotope ratio analysis. FEMS Microbiol Lett 182:207-211
18. Goupry S, Gentil E, Rochut N, Robins RJ (2000b) Evaluation of solid-phase microextraction for the isotopic analysis of volatile compounds produced during fermentation by lactic acid bacteria. J Agric Food Chem 48:2222-2227
19. Goupy J (1993) Methods for experimental design. Principles and applications for physicians and chemists. Elsevier, Amsterdam
20. Goupy J (2001) La méthode des plans d'expériences: optimisation du choix des essais et de l'interprétation des résultats, 3rd edn. Dunod, Paris
21. Hamilton IR, Gauthier L, Desjardin B, Vadeboncoeur C (1989) Concentration-dependent repression of the soluble and membrane components of the phosphoenolpyruvate:sugar phosphotransferase system by glucose. J Bacteriol 171:2942-2948
22. Hoefnagel MHN, Starrenburg MJC, Martens DE, Hugenholtz J, Kleerebezem M, Swam II van, Bongers R, Westerhoff HV, Snoep JL (2002) Metabolic engineering of lactic acid bacteria, the combined approach: kinetic modelling, metabolic control and experimental analysis. Microbiology 148:1003-1013
23. Hugenholtz J (1993) Citrate metabolism in lactic acid bacteria. FEMS Microbiol Rev 12:165-178
24. Hugenholtz J, Perdon L, Abee T (1993) Growth and energy generation by Lactococcus lactis subsp. lactis biovar. diacetylactis during citrate metabolism. Appl Environ Microbiol 59:4216-4222
25. Law BA (1981) The formation of aroma and flavour compounds in the fermented dairy products. Dairy Sci Abstr 43:143-154
26. Magni C, Lopez P, Mendoza D de (1996) The properties of citrate transport catalysed by CitP of Lactococcus lactis ssp. lactis biovar. diacetylactis. FEMS Microbiol Lett 142:265-269
27. Magni C, Mendoza D de, Konings WN, Lolkema JS (1999) Mechanism of citrate metabolism in Lactococcus lactis: resistance against lactate toxicity at low pH. J Bacteriol 181:1451-1457
28. O'Leary MH (1981) Carbon isotope fractionation in plants. Phytochemistry 20:553-567
29. Petit C, Vilchez F, Marczak R (1989) Influence of citrate on the diacetyl and acetoin production by fully grown cells of Streptococcus lactis subsp. diacetylactis. Curr Microbiol 19:319-327
30. 13C nuclear magnetic resonance studies of citrate and glucose cometabolism by Lactococcus lactis. Appl Environ Microbiol 60:1739-1748
31. Silvestre V, Goupry S, Trierweiler M, Robins RJ, Akoka S (2001) Determination of substrate and product concentrations in lactic acid bacterial fermentation by proton NMR using the ERETIC method. Anal Chem 73:1862-1868
32. Sjöberg A, Persson I, Quednau M, Hahn-Hägerdal B (1995) The influence of limiting and non-limiting growth conditions on glucose and maltose metabolism in Lactococcus lactis ssp. lactis strains. Appl Microbiol Biotechnol 42:931-938
33. Snoep JL, Teixeira de Mattos MJ, Starrenburg MJ, Hugenholtz J (1992) Isolation, characterization, and physiological role of the pyruvate dehydrogenase complex and alpha-acetolactate synthase of Lactococcus lactis subsp lactis bv. diacetylactis. J Bacteriology 174:4838-4841
34. Terzaghi BE, Sandine WE (1975) Improved medium for lactic streptococci and their bacteriophages. Appl Microbiol 29:807-813
35. van Beynum J, Pette JW (1939) The decomposition of citric acid by Betacoccus cremoris. J Dairy Res 10:250-266
36. 13C nuclear magnetic resonance. Appl Environ Microbiol 57:3371-3377