Hepatitis B Virus Gene in Liver Tissue Promotes Hepatocellular Carcinoma Development in Chronic Hepatitis C Patients

Digestive Diseases and Sciences

Volumn 48, Issue 10, 2003, Pages 1920-1924

  Fujioka, Shin Ichi ^a,b   Shimomura, Hiroyuki ^b,c   Iwasaki, Yoshiaki ^b   Fujio, Kozo ^b   Nakagawa, Hiroshi ^b   Onishi, Yasuhiro ^b   Takagi, Shinjiro ^b   Taniguchi, Hideaki ^b   Umeoka, Fumi ^b   Nakajima, Hirofumi ^b   Moriya, Akio ^b   Nanba, Katsuyuki ^b   Piao, Cheng Yu ^b   Shinji, Toshiyuki ^b   Koide, Norio ^a   Shiratori, Yasush ^b  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

^c NONE   (Japan)

Author keywords

Chronic hepatitis C; Hepatitis B virus; Hepatitis B virus DNA; Hepatocarcinogenesis; Hepatocellular carcinoma

Indexed keywords

HEPATITIS B SURFACE ANTIGEN; HEPATITIS C VIRUS ANTIBODY; UNCLASSIFIED DRUG; VIRUS ANTIBODY; VIRUS DNA;

ADULT; AGED; ARTICLE; CHRONIC HEPATITIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DNA DETERMINATION; FEMALE; GENE ISOLATION; HEPATITIS B VIRUS; HEPATITIS C; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; LIVER INJURY; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; STATISTICAL SIGNIFICANCE; VIRUS CARCINOGENESIS; VIRUS DIAGNOSIS; VIRUS GENE;

AGED; CARCINOMA, HEPATOCELLULAR; FEMALE; HEPATITIS B VIRUS; HEPATITIS C, CHRONIC; HUMANS; LIVER; LIVER NEOPLASMS; MALE; MIDDLE AGED;

EID: 0242486854     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026153800896     Document Type: Article

References (30)

1. Mitri MSD, Poussin K, Baccarini P, Pontisso P, D'Errico A, Simon N, Grigioni W, Alberti A, Beaugrand M, Pisi E, Brechot C, Paterlini P: HCV-associated liver cancer without cirrhosis. Lancet 345:413-415, 1995
2. Urashima T, Saigo K, Kobayashi S, Imaseki H, Koide Y, Asano T, Kondo Y, Koike K, Isono K: Identification of hepatitis B virus integration in hepatitis C virus-infected hepatocellular carcinoma tissues. J Hepatol 26:771-778, 1997
3. Shintani Y, Yotsuyanagi H, Moriya K, Fujie H, Tatsumi T, Takeyama T, Makuuti M, Kimura S, Koike K: The significance of hepatitis B virus DNA detected in hepatocellular carcinoma of patients with hepatitis C. Cancer 88:2478-2486, 2000
4. Tamori A, Nishiguchi S, Kubo S, Koh N, Moriyama Y, Fujimoto S, Takeda T, Shiomi S, Hirohashi K, Kinoshita H, Otani S, Kuroki T: Possible contribution to hepatocarcinogenesis of X transcript of hepatitis B virus in Japanese patients with hepatitis C virus. Hepatology 29:1429-1434, 1999
5. Ishak K, Baptista A, Bianchi L, Callea F, Groote JD, Gudat F, Denk H, Desmet V, Korb G, MacSween RMN, Phillips MJ, Portmann BG, Poulsen H, Scheuer PJ, Scmid M, Thaler H: Histological grading and staging of chronic hepatitis. J Hepatol 22:696-699, 1995
6. Kaneko S, Feinstone SM, Miller RM: Rapid and sensitive method for the detection of serum hepatitis B virus DNA using the polymerase chain reaction technique. J Clin Microbiol 27:1930-1933, 1989
7. Tsurimoto T, Fujiyama A, Matsubara K: Stable expression and replications of hepatitis B virus genome in an integrated state in a human hepatoma cell line transfected with the cloned viral DNA. Proc Natl Acad Sci USA 84:444-448, 1987
8. Brechot C, Degos F, Lugassy C, Thiers V, Zafrani S, Franco D, Bismuth H, Trepo C, Benahamou J-P, Wands J, Isserbacher K, Tiollais P, Berthelot P: Hepatitis B virus DNA in patients with chronic liver disease and negative tests for hepatitis B surface antigen. N Engl J Med 312:270-276, 1985
9. Patrlini P, Gerkin G, Nakajima E, Terre S, D'Errico A, Grigioni W, Nalpas B, Franco D, Wands J, Kew M, Pisi E, Tiollais P, Brechot C: Polymerase chain reaction to detect hepatitis B virus DNA and RNA sequences in primary liver cancers from patients negative for hepatitis B surface antigen. N Engl J Med 323:80-85, 1990
10. Sardo MA, Rodino G, Pernice M, Campo S, Squadrito G, Russo F, Raimond G: Inapparent "wild-type" and "e-minus variant" HBV infection in patients with HCV-related chronic hepatitis. Liver 14:241-244, 1994
11. Koike K, Kobayashi M, Gondo M, Hayashi I, Osuga T, Takada S: Hepatitis B virus DNA is frequently found in liver biopsy samples from hepatitis C virus-infected chronic hepatitis patients. J Med Virol 54:249-255, 1998
12. Villa E, Grottola A, Buttafoco P, Trande P, Merighi A, Fratti N, Fratti N, Seium Y, Cioni G, Manetenti F: Evidence for hepatitis B virus infection in patients with chronic hepatitis C with and without serological markers of hepatitis B. Dig Dis Sci 40:8-13, 1995
13. Cacciola I, Pollicino T, Squadrito G, Cerenzia G, Elena M, Raimond G: Occult hepatitis B virus infection in patients with chronic hepatitis C liver disease. N Engl J Med 341:22-26, 1999
14. Michalak TI, Pasquinelli C, Guilhot S, Chisari FV: Hepatitis B virus persistence after recovery from acute viral hepatitis. J Clin Invest 93:230-239, 1994
15. Rehermann B, Ferrari C, Pasquinelli C, Chisari FV: The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response. Nature Med 10:1101-1108, 1996
16. Yotsuyanagi H, Yasuda K, Iino S, Moriya K, Shintani Y, Fujie H, Tsutsumi T, Kimura S, Koike K: Persistent viremia after recovery from self-limited acute hepatitis B. Hepatology 27:1377-1382, 1998
17. Mason A, Yoffe B, Noonan C, Mearns M, Campbell C, Kellely A, Perrillo RP: Hepatitis B virus DNA in peripheral-blood mononuclear cells in chronic hepatitis B after HBsAg clearance. Hepatology 16:36-41, 1992
18. Loriot M-A, Marecellin P, Walker F, Boyer N, Degott C, Randorianatoavina I, Benhamou J-P, Erlinger S: Persistence of hepatitis B virus DNA in serum and liver form patients with chronic hepatitis B after loss of HBsAg. J Hepatol 27:251-258, 1997
19. Mason AL, Xu L, Guo L, Kuhns M, Perrillo RP: Molecular basis for persistent hepatitis B virus infection in the liver after clearance of serum hepatitis B surface antigen. Hepatology 27:1736-1742, 1998
20. Okada S, Sato T, Okusaka T, Ishii H, Ikeda M, Kosakamoto H, Yoshimori M, Wakabayashi K: Past exposure to hepatitis B as a risk factor for hepatocellular carcinoma in patients with chronic liver disease. Br J Cancer 77:2028-2031, 1998
21. Kubo S, Nishiguchi S, Hirohashi K, Tanaka H, Tsukamoto T, Hamba H, Shuto T, Yamamoto T, Ikebe T, Kinoshita H: Clinical significance of prior hepatitis B virus infection in patients with hepatitis C virus-related hepatocellular carcinoma. Cancer, 86:793-798, 1999
22. Shiratori Y, Shiina S, Zang PY, Ohno E, Okudaira T, Payawal DA, Ono-nita SK, Imamura M, Kato N, Omata M: Does dual infection by hepatitis B viruses play an important role in the pathogenesis of hepatocellular carcinoma in Japan? Cancer 80:2060-2067, 1997
23. Stevens CE, Taylor PE, PinDyck J, Choo QL, Bradley DW, Kuo G, Houghton M: Epidemiology of hepatitis C virus: a preliminary study in volunteer blood donors. JAMA 263:49-53, 1990
24. Biscegile AM, Order SE, Klein JL, Waggoner JG, Sjogren MH, Kuo G, Houghton M, Choo Q-L, Hoofnagle J: The role of chronic viral hepatitis in hepatocellular carcinoma in the United States. Am J Gastroenterol 86:335-338, 1991
25. Chan HL, Tsang SW, Leung NW, Tse CH, Hui Y, Tam JS, Chan FK, Sung JJ: Occult HBV infection in cryptogenic liver cirrhosis in an area with high prevalence of HBV infection. Am J Gastroenterol 97:1211-1215, 2002
26. Kawai S, Yokosuka O, Imazeki F, Maru Y, Saisho H: State of HBV DNA in HBsAg-negative, anti-HCV-positive hepatocellular carcinoma: Existence of HBV DNA possibly as nonintegrated form with analysis by Alu-HBV DNA PCR and conventional HBV PCR. J Med Virol 64:410-418, 2001
27. Beasley RP, Hwang L-Y, Lin C-C, Chien C-S: Hepatocellular carcinoma and hepatitis B virus. Lancet 21:1129-1133, 1981
28. Chisari FV, Klopchin K, Moriyama T, Pasquinelli C, Dunsford HA, Sell S, Pinkert CA, Brinster RL, Palmiter RD: Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell 59:1145-1156, 1989
29. Paterlini P, Poussin K, Kew M, Franco D, Brechot C: Selective accumulation of the X transcripts of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma. Hepatology 21:313-321, 1995
30. Tarao K, Rino Y, Ohkawa S, Shimizu A, Tamai S, Miyakawa K, Aoki H, Imada T, Shindo K, Okamoto N, Totsuka S: Association between high serum alanine aminotransferase levels and more rapid development and higher rate of incidence of hepatocellular carcinoma in patients with hepatitis C virus-associated cirrhosis. Cancer 86:589-595, 1999