Safety of Aquaflor (Florfenicol, 50% Type A Medicated Article), Administered in Feed to Channel Catfish, Ictalurus punctatus

Toxicologic Pathology

Volumn 31, Issue 6, 2003, Pages 689-697

  Gaikowski, Mark P ^a   Wolf, Jeffrey C ^b   Endris, Richard G ^c   Gingerich, William H ^a  

^a UPPER MIDWEST ENVIRONMENTAL SCIENCES CENTER   (United States)

^b EXPERIMENTAL PATHOLOGY LABORATORIES INC   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Aquaflor; channel catfish; enteric septicemia; florfenicol; medicated feed

Indexed keywords

FLORFENICOL; WATER;

ANIMAL BEHAVIOR; ANIMAL MODEL; ANIMAL TISSUE; APPETITE; ARTICLE; BODY WEIGHT; CHANNEL CATFISH; CHEMISTRY; CONTROLLED STUDY; DOSE RESPONSE; FEEDING; FOOD INTAKE; HEMATOPOIETIC TISSUE; HISTOPATHOLOGY; KIDNEY; MEASUREMENT; MORTALITY; NONHUMAN; OBSERVATION; PARAMETER; PRIORITY JOURNAL; SAFETY; SPLEEN; WEIGHT;

ANIMAL FEED; ANIMALS; ANTI-BACTERIAL AGENTS; BEHAVIOR, ANIMAL; BODY WEIGHT; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; HEMATOPOIESIS; ICTALURIDAE; KIDNEY; LONGEVITY; LYMPHOID TISSUE; SPLEEN; THIAMPHENICOL; TOXICITY TESTS;

ANIMALIA; CATFISH; EDWARDSIELLA ICTALURI; ENTEROBACTERIACEAE; ICTALURUS; ICTALURUS PUNCTATUS; NEGIBACTERIA;

EID: 0242468768     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/01926230390241828     Document Type: Article

References (38)

1. Abou-Kahil S., Abou-Kahil WH, Whitney PL, Yunis AA (1987). Importance of the mitochondrial amino acid pool in the sensitivity of erythroid cells to chloramphenicol: role of glycine and serine. Pharmacology 35: 308-316.
2. AOAC (Association of Official Analytical Chemists) (1998). In: Official Methods of Analysis of AOAC International. 16th edn, 5th revision, Cunniff P (ed). Author, Gaithersburg, Maryland.
3. APHA (American Public Health Association, American Water Works Association, and Water Environment Federation) (1995). Standard Methods for the Examination of Water and Wastewater. 19th edn. APHA, Washington, DC.
4. Baxa DV, Hedrick RP (1989). Two more species are susceptible to experimental infections with Edwardsiella ictaluri. Fish Health Section/American Fisheries Society Newsletter. 17: 4.
5. Burns KF, Timmons EH, Poiley SM (1971). Serum chemistry and hematological values for axenic (germfree) and environmentally associated inbred rats. Lab Anim Sci 24: 415-419.
6. Cannon M., Harford S., Davies J. (1990). A comparative study on the inhibitory actions of chloramphenicol, thiamphenicol and some fluorinated derivatives. J Antimicrob Chemother 26: 307-317.
7. Close B. (Chair), Banister K., Baumans V., Bernoth E., Bromage N., Bunyan J., Erhardt W., Flecknell P., Gregory N., Hackbarth H., Morton D., Warwick C. (1996). Recommendations for euthanasia of experimental animals: part 1. Lab Anim 30: 293-316.
8. Close B. (Chair), Banister K., Baumans V., Bernoth E., Bromage N., Bunyan J., Erhardt W., Flecknell P., Gregory N., Hackbarth H., Morton D., Warwick C. (1997). Recommendations for euthanasia of experimental animals: part 2. Lab Anim 31: 1-32.
9. Ferrari V., Pajola E. (1981). Types of haemopoeitic inhibition by chloramphenicol and thiamphenicol. In: Safety Problems Related to Chloramphenicol and Thiamphenicol Therapy, Najean Y, Tognoni G, Yunis AA (eds). Raven Press, New York, pp 43-59.
10. Fukui H., Fujihara Y., Kano T. (1987). In vitro and in vivo antibacterial activities of florfenicol, a new fluorinated analog of thiamphenicol, against fish pathogens. Fish Pathol 22(4): 201-207.
11. Grizzle JM, Rogers WA (1976). Anatomy and histology of the channel catfish. Auburn University Agricultural Experiment Station, Auburn, AL, USA, pp 29-30.
12. Grondel JL, Nouws JFM, van Muiswinkel WW (1987a). The influence of antibiotics on the immune system: immuno-pharmokinetic investigations on the primary anti-SRBC response in carp, Cyprinus carpio L., after oxytetracycline injection. J Fish Dis 10: 35-43.
13. Grondel JL, Nouws JFM, De Jong M., Schutte AR, Driessens F. (1987b). Pharmacokinetics and tissue distribution of oxytetracycline in carp, Cyprinus carpio L., following different routes of administration. J Fish Dis 10: 153-163.
14. Hashimoto M., Hashimoto N. (1968). Histological study of bone marrow in breeding rats. In: Advances in Germfree Research and Gnotobiology, Miyakawa M, Luckey TD (eds). CRC Press, Cleveland, pp 149-161.
15. Horsberg TB, Martinsen B., Varma KJ (1994). The disposition of 14C-florfenicol in Atlantic salmon (Salmo salar). Aquaculture 122: 97-106.
16. Iijima S., Yamane T. (1968). The spleen of animals germfree. In: Advances in Germfree Research and Gnotobiology, Miyakawa M, Luckey TD (eds). CRC Press, Cleveland, pp 139-148.
17. Inglis V., Richards RH, Varma KJ, Sutherland IH, Brokken ES (1991). Florfenicol in Atlantic salmon, Salmo salar L, parr: tolerance and assessment of efficacy against furunculosis. J Fish Dis 14: 343-351.
18. Keiser G., Buchegger U. (1973). Hematological side effects of chloramphenicol and thiamphenicol. Helvetica Medica Acta 37: 365-278.
19. Klausen B., Hougen HP (1987). Quantitative studies of lymphoid organs, blood and lymph in inbred athymic and euthymic LEW rats under germfree and specific-pathogen-free conditions. Lab Anim 21: 342-347.
20. Lunden T., Bylund G. (2000). The influence of in vitro and in vivo exposure to antibiotics on mitogen-induced proliferation of lymphoid cells in rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol 10: 395-404.
21. Lunden T., Miettinen S., Lönnström L-G., Lilius E-M., Bylund G. (1998). Influence of oxytetracycline and oxolinic acid on the immune response of rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol 8: 217-230.
22. Lunden T., Miettinen S., Lönnström L-G., Lilius E-M., Bylund G. (1999). Effect of florfenicol on the immune response of rainbow trout (Oncorhynchus mykiss). Vet Immunol Immunopathol 8: 217-230.
23. Nagabhushan T., Miller GH, Varma KJ (1992). Chloramphenicol and Analogues. In: Offprints from Kirk-Othmer: Encyclopedia of Chemical Technology, 4th edn, vol 2. John Wiley and Sons, Inc, New York, pp 961-978.
24. Penny RHC, Watson ADJ, Moyle GG (1973). Observations of the effects of chloramphenicol and starvation on the haemopoietic system of the dog. Clin Toxicol 6: 229-246.
25. Plumb JA, Sanchez DJ (1983). Susceptibility of five species of fish to Edwardsiella ictaluri. J Fish Dis 6: 261-266.
26. Rijkers GT, Teunissen AG, Van Oosterom R., van Muiswinkel WB (1980). The immune system of cyprinid fish. The immunosuppressive effect of the antibiotic oxytetracycline in carp (Cyprinus carpio L.). Aquaculture 19: 177-189.
27. SAS Institute Inc (1997). SAS/STAT Software: Changes and enhancements through release 6.12. SAS Institute Inc, Cary, NC.
28. Shapiro SS, Wilk MB (1965). An analysis of variance test for normality (complete samples). Biometrika 52: 591-611.
29. Schering-Plough Animal Health (SPAH) (2001). Aquaflor technical monograph. Union, NJ.
30. Schering-Plough Research Institute (SPRI) (2001). Method transfer report—florfenicol in fish feed; procedure 025298-123A-007-01. Lafayette, NJ.
31. Sieroslawska AM, Studnicka AK, Siwicki A., Bownik A., Rymuszka A., Slonka J. (1998). Antibiotics and cell-mediated immunity in fish—in vitro study. Acta Vet Brno 67: 329-334.
32. Tucker CS, Robinson EH (1990). Channel catfish farming handbook. Van Nostrand Reinhold, New York.
33. Uno Y., Sumi Y., Sakura K. (1968). Studies on the thymus of germfree rats. In: Advances in Germfree Research and Gnotobiology, Miyakawa M, Luckey TD (eds). CRC Press, Cleveland, pp 129-137.
34. US Food and Drug Administration. (1991). Good Laboratory Practices for Nonclinical Laboratory Studies. Food and Drug Administration, 21 Code of Federal Registration Part 58, USFDA, Washington, DC.
35. Varma KJ, Adams PE, Powers TE, Powers JD, Lamendola JF (1986), Pharmacokinetics of florfenicol in veal calves. J Vet Pharm Ther 9: 412-425.
36. Watson, ADJ (1977). Chloramphenicol toxicity in dogs. Res Vet Sci 23: 66-69.
37. Yunis AA (1988). Chloramphenicol: relation of structure to activity. Annu Rev Pharmacol Toxicol 28: 83-100.
38. Yunis AA, Manyan DR, Arimura GK (1974). Comparative metabolic effects of chloramphenicol and thiamphenicol in mammalian cells. Postgrad Med J 50 (Suppl 5): 60-65.