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Volumn 18, Issue 50, 1977, Pages 4361-4364

An efficient general synthesis of ω-olefinic methyl esters

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Indexed keywords


EID: 0242452539     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(01)83508-5     Document Type: Article
Times cited : (70)

References (20)
  • 6
    • 84918302964 scopus 로고    scopus 로고
    • During the course of this investigation Professor T. Ross Kelly informed us that lithium thiomethoxide in HMPA at room temperature is an effective reagent for alkyl-oxygen cleavage of lactones and aryl methyl ethers; T. R. Kelly, B. B. Dali and W.-G. Tsang, Tetrahedron Letters, in press.
  • 8
    • 84981755231 scopus 로고
    • Die Aufspaltung des γ-Butyrolactons und α-Amino-γ-butyrolactons mit Natriummethylmercaptid bzw.-selenid. Eine Synthese des Methionins
    • (1950) Chemische Berichte , vol.83 , pp. 265
    • Plieninger1
  • 9
    • 0001202009 scopus 로고
    • Hypophosphorous Acid, a Novel Reagent for the Reduction of Diselenides and the Selenol-Catalyzed Reduction of Disulfides1,2
    • (1966) The Journal of Organic Chemistry , vol.31 , pp. 1202
    • Gunther1
  • 13
    • 0017405222 scopus 로고
    • Regioselective O-demethylation in the aporphine alkaloid series
    • For an example of the demethylation of aryl methyl ethers with sodium benzyl selenolate see:
    • (1976) The Journal of Organic Chemistry , vol.42 , pp. 1228
    • Ahmad1    Saá2    Cava3
  • 16
    • 84918302961 scopus 로고    scopus 로고
    • Similar results have been obtained by Professor Dennis Liotta and associates (H. Santiesteban and W. Markiewicz) of Emory University; see accompanying articles. We wish to thank Professor Liotta for providing us with a preprint of their work prior to publication.
  • 17
    • 84918302960 scopus 로고    scopus 로고
    • Treatment of butyrolactone with lithium phenyl selenolate in HMPA at 70° C also effects ring cleavage albeit in only 30% yield. This reagent, an air sensitive high melting solid (295-3000C with decomp.), was prepared by treating a benzene solution of phenyl selenol [W. G. Salmond, M. A. Barta A. M. Cain and M. C. Sobala, Tetrahedron Letters, 1683 (1977)] with 1.1 eq of methyl lithium. Removal of the solvent in vacuo and trituration with dry ether yields the reagent as an off white solid.
  • 18
    • 84918302959 scopus 로고    scopus 로고
    • 3) spectra as well as elemental analysis.
  • 20
    • 84918302958 scopus 로고    scopus 로고
    • In a related study we have demonstrated that sodium phenyl selenolate in DMF effects nucleophilic ring cleavage of such monoactivated cyclopropanes as 2-acetylcyclopropane and bicyclo[3.1.0]-2-hexanone. The results of this study will be forthcoming in the near future.


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