Immunohistochemical localization of amylin in human pancreas, thyroid, pituitary and their tumors

Acta Histochemica

Volumn 105, Issue 4, 2003, Pages 303-307

  Rotondo, Fabio ^a   Vidal, Sergio ^b   Bell, David ^a   Horvath, Eva ^a   Kovacs, Kalman ^a   Scheithauer, Bernd W ^c   Lloyd, Ricardo V ^c  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c MAYO CLINIC   (United States)

Author keywords

Amylin; Immunohistochemistry; Neoplasm; Pancreas; Pituitary; Thyroid

Indexed keywords

AMINO ACIDS; BIOLOGICAL ORGANS; CELLS; ENZYME KINETICS; HISTOLOGY; INSULIN; TUMORS;

PANCREATIC TISSUES;

IMMUNOLOGY;

AMYLIN; AMYLOID; BIOTIN; INSULIN; PEROXIDASE; PROLACTIN; STREPTAVIDIN;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; HYPOPHYSIS TUMOR; IMMUNOHISTOCHEMISTRY; INSULIN RELEASE; PANCREAS; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL TUMOR; PANCREAS TUMOR; PROLACTINOMA; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; THYROID MEDULLARY CARCINOMA; THYROID TUMOR;

EID: 0242443338     PISSN: 00651281     EISSN: None     Source Type: Journal    
DOI: 10.1078/0065-1281-00718     Document Type: Article

References (22)

1. Alevizaki M, Dai K, Grigorakis SI, Legon S, and Souvatzoglou A (1994) Amylin/islet amyloid polypeptide expression in medullary carcinoma of the thyroid: correlation with the expression of the related calcitonin/CGRP genes. Clin Endocrinol 41: 21-26
2. Alevizaki M, Grigorakis SI, Tseleni-Balafouta S, Alevizaki CC, Philippou G, Anastasiou E, and Souvatzoglou A (2001) High plasma amylin/islet amyloid polypeptide levels in patients with residual medullary thyroid carcinoma after total thyroidectomy. Eur J Endocrinol 145: 585-589
3. Bere-Medhin S, Olofsson C, and Mulder H (2000) Islet amyloid polypeptide in the islets of Langerhans: friend or foe? Diabetologia 43: 687-695
4. Christmanson L, Rorsman F, Stenman G, Westermark P, and Betsholtz C (1990) The human islet amyloid polypeptide (IAPP) gene. Organization, chromosomal localization and functional identification of a promotor region. FEBS Lett 267: 160-166
5. Cooper GJ (1994) Amylin compared with calcitonin gene-related peptide: structure, biology and relevance to metabolic disease. Endocr Rev 15: 163-201
6. Denijn M, De Weger RA, Van Mansfeld AD, Van Unnik JA, and Lips CJ (1992) Islet amyloid polypeptide (IAPP) is synthesized in the islets of Langerhans. Detection of IAPP polypeptide and IAPP mRNA by combined in situ hybridization and immunohistochemistry in rat pancreas. Histochemistry 97: 33-37
7. Kahn SE, Andrikopoulos S, and Verchere CB (1999) Islet amyloid. A long-recognized but underappreciated pathological feature of type 2 diabetes. Diabetes 48: 241-253
8. Knerr I, Schuster S, Nomikos P, Buchfelder M, Dotsch J, Schoof E, Fahlbusch R, and Rascher W (2001) Gene expression of adrenomedullin, leptin, their receptors and neuropeptide Y in hormone-secreting and non-functioning pituitary adenomas, meningiomas and malignant intracranial tumours in humans. Neuropathol Appl Neurobiol 27: 215-222
9. Kovacs K, Lloyd RV, Horvath E, Asa SL, Stefaneanu L, Killenger DW, and Smyth HS (1989) Silent somatotroph adenomas of the human pituitary. A morphologic study of three cases including immunocytochemistry, electron microscopy, in vitro examination and in situ hybridization. Am J Pathol 134: 345-353
10. Kovacs K, Stefaneanu L, Horvath E, Lloyd RV, Lancranjan I, Buchfelder M, and Fahlbusch R (1991) Effect of dopamine agonist medication on prolactin producing pituitary adenomas. A morphological study including immunocytochemistry, electron microscopy and in situ hybridization. Virch Arch (A) Pathol Anat 418: 439-446
11. Ludvik B, Kautzky-Willer A, Prager R, Thomaseth K, and Pacini G (1997) Amylin: history and overview. Diabet Med 14: S9-S13
12. Lukinius A, Wilander E, Westermark GT, Engstrom U, and Westermark P (1989) Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets. Diabetologia 32: 240-244
13. Mosselman S, Hoppener JW, Zandberg J, Van Mansfeld AD, Geurts van Kessel AH, Lips CJ, and Jansz HS (1988) Islet amyloid polypeptide: identification and chromosomal localization of the human gene. FEBS Lett 239: 227-232
14. Muff R, Born W, and Fischer JA (1995) Calcitonin, calcitonin gene-related peptide, adrenomedullin and amylin: homologous peptides, separate receptors and overlapping biological actions. Eur J Endocrinol 133: 17-20
15. Mulder H, Lindh AC, Ekblad E, Westermark P, and Sundler F (1994) Islet amyloid polypeptide is expressed in endocrine cells of the gastric mucosa in the rat and mouse. Gastroenterology 107: 712-719
16. Mulder H, Leckstrom A, Uddman R, Ekblad E, Westermark P, and Sundler F (1995) Islet amyloid polypeptide (amylin) is expressed in sensory neurons. J Neurosci 15: 1625-1632
17. Nishi M, Sanke T, Seino S, Eddy RL, Fan Y-S, Byers MG, Shows TB, Bell GI, and Steiner DF (1989) Human islet amyloid polypeptide gene: complete nucleotide sequence, chromosomal localization, and evolutionary history. Mol Endocrinol 3: 1775-1781
18. Scherbaum WA (1998) The role of amylin in the physiology of glycemic control. Clin Endocrinol Diabet 106: 97-102
19. Thapar K, Kovacs K, and Muller PJ (1995) Clinical-pathological correlations of pituitary tumours. Baill Clin Endocrinol Metab 9: 243-270
20. Vidal S, Kovacs K, Horvath E, Scheithauer BW, Kuroki T, and Lloyd RV (2001) Microvessel density in pituitary adenomas and carcinomas. Virchows Arch 438: 595-602
21. Westermark P, Wemstedt C, O'Brien TD, Hayden DW, and Johnson KH (1987) Islet Amyloid in type 2 human diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone. Am J Pathol 127: 414-417
22. Wimalawansa SJ (1997) Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily. Crit Rev Neurobiol 11: 167-239