Management of Leg Ulcers

Seminars in Cutaneous Medicine and Surgery

Volumn 22, Issue 3, 2003, Pages 212-221

  Kantor, Jonathan ^b   Margolis, David J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM HYDROXIDE; ANTACID AGENT; BECAPLERMIN; CEFALEXIN; CEFOXITIN; CEFTAZIDIME; CEPHALOSPORIN DERIVATIVE; CILASTATIN PLUS IMIPENEM; CLINDAMYCIN; MAGNESIUM OXIDE; MORPHINE SULFATE; PENTOXIFYLLINE; PIPERACILLIN PLUS TAZOBACTAM; PLATELET DERIVED GROWTH FACTOR; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT GROWTH FACTOR; SULTAMICILLIN; ZINC; ZINC ACETATE;

ANTIBIOTIC THERAPY; COST EFFECTIVENESS ANALYSIS; HUMAN; INFECTION; LEG COMPRESSION; LEG ULCER; PROGNOSIS; REVIEW; SKIN GRAFT; TECHNIQUE; VITAMIN SUPPLEMENTATION; WOUND; WOUND CARE; WOUND HEALING;

ANTI-BACTERIAL AGENTS; BANDAGES; GROWTH SUBSTANCES; HUMANS; LEG ULCER; PAIN; PROGNOSIS; SKIN TRANSPLANTATION;

EID: 0242441974     PISSN: 10855629     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1085-5629(03)00043-9     Document Type: Review

References (84)

1. Baker SR, Stacey MC, Singh G, et al: Aetiology of chronic leg ulcers. Eur J Vasc Surg 6:245-251, 1992
2. Falanga V, Kirsner R, Katz MH, et al: Pericapillary fibrin cuffs in venous ulceration: Persistence with treatment and during ulcer healing. J Dermatol Surg Oncol 18:409-414, 1993
3. Weingarten MS: State-of-the-art treatment of chronic venous disease. Clin Infect Dis 32:949-954, 2001
4. Margolis DJ, Bilker W, Santanna J, et al: Venous leg ulcer: Incidence and prevalence in the elderly. J Am Acad Dermatol 46:381-386, 2002
5. Stromberg K, Chapekar MS, Goldman BA, et al: Regulatory concerns in the development of topical recombinant ophthalmic and cutaneous wound healing biologics. Wound Repair Regeneration 2:155-164, 1994
6. Falanga V, Margolis D, Alvarez O, et al: Rapid healing of venous ulcers and lack of clinical rejection with an allogeneic cultured human skin equivalent. Arch Dermatol 134:293-300, 1998
7. Callam MJ, Harper DR, Dale JJ, et al: Chronic ulcer of the leg: Clinical history. Br Med J Clin Res Ed 294:1389-1391, 1987
8. Nelzen O, Bergqvist D, Lindhagen A, et al: Chronic leg ulcers: an underestimated problem in primary health care among elderly patients. J Epidemiol Community Health 45: 184-187, 1991
9. Franks PJ, Wright DD, Moffatt CJ, et al: Prevalence of venous disease: a community study in west London. Eur J Surg 158:143-147, 1992
10. Margolis DJ, Cohen JH: Management of chronic venous leg ulcers: A literature-guided approach. Clin Dermatol 12:19-26, 1994
11. Fletcher A, Cullum F, Sheldon TA: A systematic review of compression treatment for venous leg ulcers. BMJ 315:576-580, 1997
12. de Araujo T, Valencia I, Federman DG, et al: Managing the patient with venous ulcers. Ann Intern Med 138:326-334, 2001
13. Braitman LE, Davidoff F: Predicting clinical states in individual patients. Ann Intern Med 125:406-412, 1996
14. Harrell FE, Lee KL, Mark DB: Multivariate prognostic models: Issues in developing models, evaluating assumptions, and adequacy, and measuring and reducing errors. Stat Med 15:361-387, 1996
15. Van Houwelingen JC, Le Cessie S: Predictive value of statistical models. Stat Med 9:1303-1325, 1990
16. Spiegelhalter DJ: Probabilistic prediction in patient management. Stat Med 5:421-433, 1986
17. Skene AJ, Smith JM, Dore CJ, et al: Venous leg ulcers: A prognostic index to predict time to healing. BMJ 305:1119-1121, 1992
18. Phillips TJ, Machado F, Trout R, et al: Prognostic indicators in venous ulcers. J Am Acad Dermatol 43:627-630, 2000
19. Margolis DJ, Berlin JA, Strom BL: Which venous leg ulcers will heal with a limb compression bandage? Am J Med 109:15-19, 2000
20. Temple R: Are surrogate markers adequate to asses cardiovascular disease drugs? JAMA 282:790-795, 1999
21. Margolis D, Gross E, Wood CR, et al: Planimetric rate of healing in venous ulcers of the leg treated with pressure bandage and hydrocolloid dressing. J Am Acad Dermatol 28:418-421, 1993
22. Tallman P, Muscare E, Carson P, et al: Initial rate of healing predicts complete healing of venous ulcers. Arch Dermatol 133:1231-1234, 1997
23. Kantor J, Margolis DJ: A multicentre study of percentage change in venous leg ulcer area as a prognostic index of healing at 24 weeks. Br J Dermatol 142:960-964, 2000
24. Gelfand JM, Hofstad O, Margolis DJ: Surrogate end-points for treatment of venous leg ulcers. J Invest Dermatol 119:1420-1425, 2002
25. Cullum N, Nelson EA, Fletcher AW, et al: Compression for venous leg ulcers. Cochrane Database Syst Rev CD000265-2001
26. Kikta MJ, Schuler JJ, Meyer JP, et al: A prospective, randomized trial of Unna's boots versus hydroactive dressing in the treatment of venous stasis ulcers. J Vasc Surg 7:478-483, 1988
27. Rubin JR, Alexander J, Plecha EJ, et al: Unna's boot vs polyurethane foam dressings for the treatment of venous ulceration. A randomized prospective study. Arch Surg 125:489-490, 1990
28. Gould DJ, Campbell S, Newton H, et al: Setopress vs Elastocrepe in chronic venous ulceration. Br J Nurs 7:66-63, 1998
29. Nelson EA: Compression bandaging in the treatment of venous leg ulcers. J Wound Care 5:415-418, 1996
30. Mani R, Vowden K, Nelson EA: Intermittent pneumatic compression for treating venous leg ulcers (Cochrane Review). Cochrane Database Syst Rev 4:CD001899-2001
31. Nelson EA, Cullum N, Jones J: Venous leg ulcers. Clin Evid 6:1502-1513, 2001
32. Schuler JJ, Maibenco T, Megerman J: Treatment of chronic venous leg ulcers using sequential gradient intermittent pneumatic compression. Phlebology 11:111-116, 1996
33. McGuckin M, Goldman R, Bolton R, et al: the clinical relevance of microbiology in acute and chronic wounds. Adv Skin Wound Care 16:2-23, 2003
34. Reiber GE, Lipsky BA, Gibbons GW: The burden of diabetic foot ulcers. Am J Surg 176:5S-105, 1998
35. Chantelau E, Tanudjaja T, Altenhofer F, et al: Antibiotic treatment for uncomplicated neuropathic forefoot ulcers in diabetes: A controlled trial. Diabet Med 13:156-159, 1996
36. Boyce ST, Warden GD, Holder IA: Cytotoxicity testing of topical antimicrobial agents on human keratinocytes and fibroblasts for cultured skin grafts. J Burn Care Rehabil 16:97-103, 1995
37. Holm J: Wound and graft infection. Clinical aspects and prophylaxis. Acta Chir Scand Suppl 529:87-89, 1985
38. Larkin JM, Moylan JA: The role of prophylactic antibiotics in burn care. Am Surg 42:247-250, 1976
39. Leaper DJ: Prophylactic and therapeutic role of antibiotics in wound care. Am J Surg 167:155-195, 1994
40. Alvarez OM, Childs EJ: Pressure ulcers. Physical, supportive, and local aspects of management. Clin Podiatr Med Surg 8:869-890, 1991
41. Lipsky BA, Berendt AR: Principles and practice of antibiotic therapy of diabetic foot infections. Diabetes Metab Res Rev 16:542-546, 2000 (suppl 1)
42. Lipsky BA, Baker PD, Landon GC, et al: Antibiotic therapy for diabetic foot infections: Comparison of two parenteral-to-oral regimens. Clin Infect Dis 24:643-648, 1997
43. Temple ME, Nahata MC: Pharmacotherapy of lower limb diabetic ulcers. J Am Geriatr Soc 48:822-828, 2000
44. O'Meara SM, Cullum NA, Majid M, et al: Systematic review of antimicrobial agents used for chronic wounds. Br J Surg 88:4-21, 2001
45. US Department of Health and Human Services Clinical Practice Guideline. Treatment of Pressure Ulcers. Agency for Healthcare Policy and Research, Silver Spring, MD, 1994
46. Margolis DJ: Pentoxifylline in the treatment of venous leg ulcers. Arch Dermatol 13:1142-1143, 2000
47. Jull AB, Waters J, Arroll B: Oral pentoxifylline for treatment of venous leg ulcers. Cochrane Database Syst Rev CD001733-2000
48. Margolis DJ, Cohen JH: Management of chronic venous leg ulcers: A literature-guided approach. Clin Dermatol 12:19-26, 1994
49. Margolis DJ, Lewis VL: A literature assessment of the use of miscellaneous topical agents, growth factors, and skin equivalents for the treatment of pressure ulcers. Dermatol Surg 21:145-148, 1995
50. Brandrup F, Menne T, Agren MS, et al: A randomized trial of two occlusive dressings in the treatment of leg ulcers. Acta Derm Venereol 70:231-235, 1990
51. Margolis DJ, Berlin JA, Strom BL: Which venous leg ulcers will heal with limb compression bandages? Am J Med 109:15-19, 2000
52. Wilkinson EA, Hawke CI: Oral zinc for arterial and venous leg ulcers. Cochrane Database Syst Rev CD001273-2000
53. Greaves MW, Ive FA: Serum-zinc and healing of venous leg ulcers. Lancet 2:1261, 1972
54. Phillips A, Davidson M, Greaves MW: Venous leg ulceration: Evaluation of zinc treatment, serum zinc and rate of healing. Clin Exp Dermatol 2:395-399, 1977
55. Hallbook T, Lanner E: Serum-zinc and healing of venous leg ulcers. Lancet 2:780-782, 1972
56. Agren MS, Franzen L, Chvapil M: Effects on wound healing of zinc oxide in a hydrocolloid dressing. J Am Acad Dermatol 29:221-227, 1993
57. Becker L, Goodemote C: Treating pressure sores with or without antacid. Am J Nurs 84:351-352, 1984
58. Maass A, Grohe C, Oberdorf S, et al: Mitogenic signals control translation of the early growth response gene- 1 in myogenic cells. Biochem Biophys Res Commun 202:1337-1346, 1994
59. Van Neste DJ, Rushton DH: Hair problems in women. Clin Dermatol 15:113-125, 1997
60. Clement DL: Management of venous edema: Insights from an international task force. Angiology 51:13-17, 2000
61. Pedersen FM, Hamberg O, Sorensen MD, et al: Effect of 0-(beta-hydroxyethyl)-rutoside (Venoruton) on symptomatic venous insufficiency in the lower limbs. Ugeskr Laeger 154: 2561-2563, 1992
62. Nocker W, Diebschlag W, Lehmacher W: A 3-month, randomized double-blind dose-response study with 0-(beta-hydroxyethyl)-rutoside oral solutions. Vasa 18:235-238, 1989
63. Nocker W, Diebschlag W: Dose-response study with 0-(beta-hydroxyethyl)-rutoside oral solution. Vasa 16:365-369, 1987
64. Bergqvist D, Hallbook T, Lindblad B, et al: A double-blind trial of 0-(beta-hydroxyethyl)-rutoside in patients with chronic venous insufficiency. Vasa 10:253-260, 1981
65. van Cauwenberge H: Double-blind study of the efficacy of a soluble rutoside derivative in the treatment of venous disease. Arch Int Pharmacodyn Ther 196:122-126, 1972 (suppl)
66. Margolis DJ, Kantor J, Santanna J, et al: Effectiveness of platelet releasate for the treatment of diabetic neuropathic foot ulcers. Diabetes Care 24:483-488, 2001
67. Smiell JM, Wieman TJ, Steed DL, et al: Efficacy and safety of becaplermin (recombinant human platelet-derived growth factor-BB) in patients with nonhealing, lower extremity diabetic ulcers: A combined analysis of four randomized studies. Wound Repair Regen 7:335-346, 1999
68. Embil JM, Papp K, Sibbald G, et al: Recombinant human platelet-derived growth factor-BB (becaplermin) for healing chronic lower extremity diabetic ulcers: An open-label clinical evaluation of efficacy. Wound Repair Regen 8:162-168, 2000
69. Ladin D: Becaplermin gel (PDGF-BB) as topical wound therapy. Plastic Surgery Educational Foundation DATA Committee. Plast Reconstr Surg 105:1230-1231, 2000
70. Margolis DJ, Kantor J, Berlin JA: Healing of diabetic neuropathic foot ulcers receiving standard treatment. A meta-analysis. Diabetes Care 22:692-695, 1999
71. Kantor J, Margolis DJ: Treatment options for diabetic neuropathic foot ulcers: A cost-effectiveness analysis. Dermatol Surg 27:347-351, 2001
72. Rees RS, Robson MC, Smiell JM, et al: Becaplermin gel in the treatment of pressure ulcers: a phase II randomized, double-blind, placebo-controlled study. Wound Repair Regen 7:141-147, 1999
73. Edmonds M, Bates M, Doxford M, et al: New treatments in ulcer healing and wound infection. Diabetes Metab Res Rev 16:S51-S54, 2000 (suppl 1)
74. Gough A, Clapperton M, Rolando N, et al: Randomised placebo-controlled trial of granulocyte-colony stimulating factor in diabetic foot infection. Lancet 350:855-859, 1997
75. de Lalla F, Pellizzer G, Strazzabosco M, et al: Randomized prospective controlled trial of recombinant granulocyte colony-stimulating factor as adjunctive therapy for limb-threatening diabetic foot infection. Antimicrob Agents Chemother 45:1094-1098, 2001
76. Jones JE, Nelson EA: Skin grafting for venous leg ulcers. Cochrane Database Syst Rev 2002
77. Veves A, Falanga V, Armstrong DG, et al: Graftskin, a human skin equivalent, is effective in the management of non-infected neuropathic diabetic foot ulcers: A prospective randomized multicenter clinical trial. Diabetes Care 24:290-295, 2001
78. Falanga V, Sabolinski M: A bilayered living skin construct (APLIGRAF) accelerates complete closure of hard-to-heal venous ulcers. Wound Repair Regen 7:201-207, 1999
79. Dolynchuk K, Hull P, Guenther L, et al: The role of Apligraf in the treatment of venous leg ulcers. Ostomy Wound Manage 45:34-43, 1999
80. Mol MA, Nanninga PB, van Eendenburg JP, et al: Grafting of venous leg ulcers. An intraindividual comparison between cultured skin equivalents and full-thickness skin punch grafts. J Am Acad Dermatol 24:77-82, 1991
81. Gould D: Wound management and pain control. Nurs Stand 14:47-54, 1999
82. Emflorgo CA: The assessment and treatment of wound pain. J Wound Care 8:384-385, 1999
83. Senecal SJ: Pain management of wound care. Nurs Clin North Am 34:847-860, 1999
84. Rook JL: Wound care pain management. Nurse Pract 22:122-126, 1997