Folic acid supplement decreases the homocysteine increasing effect of filtered coffee. A randomised placebo-controlled study

European Journal of Clinical Nutrition

Volumn 57, Issue 11, 2003, Pages 1411-1417

  Strandhagen, Elisabeth ^a   Landaas, S ^b   Thelle, D S ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

Controlled study; Filtered coffee; Folic acid; Homocysteine; Pyridoxine

Indexed keywords

COBALAMIN; FOLIC ACID; HOMOCYSTEINE; PLACEBO; PYRIDOXINE;

ABSTINENCE; ADULT; AGED; AMINO ACID BLOOD LEVEL; ARTICLE; BLOOD; BLOOD PRESSURE MEASUREMENT; BODY MASS; CIGARETTE SMOKING; CLINICAL TRIAL; COFFEE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; FEMALE; FOLIC ACID BLOOD LEVEL; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPERHOMOCYSTEINEMIA; ISCHEMIC HEART DISEASE; MALE; METABOLISM; NEURAL TUBE DEFECT; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; VOLUNTEER;

EID: 0242440774     PISSN: 09543007     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejcn.1601703     Document Type: Article

References (38)

1. Bak A (1990): Coffee and Cardiovascular Risk; An Epidemiological Study. Rotterdam: Erasmus Univerisity.
2. Bosy-Westphal A, Holzapfel A, Czech N & Müller MJ (2001): Plasma folate but not vitamin B(12) or homocysteine concentrations are reduced after short-term vitamin B(6) supplementation. Ann. Nutr. Metab. 45, 255-258.
3. Boushey CJ, Beresford SA, Omenn GS & Motulsky AG (1995): A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 274, 1049-1057.
4. Christensen B, Mosdol A, Retterstol L, Landaas S & Thelle DS (2001): Abstention from filtered coffee reduces the concentrations of plasma homocysteine and serum cholesterol - a randomized controlled trial. Am. J. Clin. Nutr. 74, 302-307.
5. Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B & Graham I (1991): Hyperhomocysteinemia: an independent risk factor for vascular disease. N. Engl. J. Med. 324, 1149-1155.
6. Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L & Ueland PM (1998): Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch. Neurol. 55, 1449-1455.
7. de Bree A, Verschuren WM, Blom HJ & Kromhout D (2001): Lifestyle factors and plasma homocysteine concentrations in a general population sample. Am. J. Epidemiol. 154, 150-154.
8. den Heijer M, Brouwer IA, Bos GM, Blom HJ, van der Put NM, Spaans AP, Rosendaal FR, Thomas CM, Haak HL, Wijermans PW & Gerrits WB (1998): Vitamin supplementation reduces blood homocysteine levels: a controlled trial in patients with venous thrombosis and healthy volunteers. Arterioscler. Thromb. Vasc. Biol. 18, 356-361.
9. Goddijn-Wessel TA, Wouters MG, van de Molen EF, Spuijbroek MD, Steegers-Theunissen RP, Blom HJ, Boers GH & Eskers TK (1996): Hyperhomocysteinemia: a risk factor for placental abruption or infarction. Eur. J. Obstet. Gynecol. Reprod. Biol. 66, 23-29.
10. Grubben MJ, Boers GH, Blom HJ, Broekhuizen R, de Jong R, van Rijt L, de Ruijter E, Swinkels DW, Nagengast FM & Katan MB (2000): Unfiltered coffee increases plasma homocysteine concentrations in healthy volunteers: a randomized trial. Am. J. Clin. Nutr. 71, 480-484.
11. Jacobsen DW, Gatautis VJ, Green R, Robinson K, Savon SR, Secic M, Ji J, Otto JM & Taylor LM Jr (1994): Rapid HPLC determination of total homocysteine and other thiols in serum and plasma: sex differences and correlation with cobalamine and folate concentrations in healthy subjects. Clin. Chem. 40, 873-881.
12. Jacques PF, Bostom AG, Wilson PW, Rich S, Rosenberg IH & Selhub J (2001): Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am. J. Clin. Nutr. 73, 613-621.
13. Koehler KM, Baumgartner RN, Garry PJ, Allen RH, Stabler SP & Rimm EB (2001): Association of folate intake and serum homocysteine in elderly persons according to vitamin supplementation and alcohol use. Am. J. Clin. Nutr. 73, 628-637.
14. Leeda M, Riyazi N, de Vries JI, Jakobs C, van Geijn HP & Dekker GA (1998): Effects of folic acid and vitamin B6 supplementation on women with hyperhomocysteinemia and a history of preeclampsia or fetal growth restriction. Am. J. Obstet. Gynecol. 179, 135-139.
15. Mansoor MA, Kristensen O, Hervig T, Bates CJ, Pentieva K, Vefring H, Osland A, Berge T, Drablos PA, Hetland O & Rolfsen S (1999): Plasma total homocysteine response to oral doses of folic acid and pyridoxine hydrochloride (vitamin B6) in healthy individuals. Oral doses of vitamin B6 reduce concentrations of serum folate. Scand. J. Clin. Lab. Invest. 59, 139-146.
16. McCaddon A, Hudson P, Davies G, Hughes A, Williams JH & Wilkinson C (2001): Homocysteine and cognitive decline in healthy elderly. Dement. Geriatr. Cogn. Disord. 12, 309-313.
17. Nelen WL, Blom HJ, Steegers EA, den Heijer M, Thomas CM & Eskes TK (2000): Homocysteine and folate levels as risk factors for recurrent early pregnancy loss. Obstet. Gynecol. 95, 519-524.
18. Nes M, Frost Andersen L, Solvoll K, Sandstad B, Hustvedt BE, Løvø A & Drevon CA (1992): Accuracy of a quantitative food frequency questionnaire applied in elderly Norwegian women. Eur. J. Clin. Nutr. 46, 809-821.
19. Nygard O, Vollset SE, Refsum H, Stensvold I, Tverdal Å, Nordrehaug JE, Ueland M & Kvale G (1995): Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study. JAMA 274, 1526-1533.
20. Nygard O, Refsum H, Ueland PM, Stensvold I, Nordrehaug JE, Kvale G & Vollset SE (1997): Coffee consumption and plasma total homocysteine: The Hordaland Homocysteine Study. Am. J. Clin. Nutr. 65, 136-143.
21. Olthof MR, Hollman PC, Zock PL & Katan MB (2001): Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans. Am. J. Clin. Nutr. 73, 532-538.
22. Oshaug A, Bugge KH & Refsum H (1998): Diet, an independent determinant for plasma total homocysteine. A cross sectional study of Norwegian workers on platforms in the North Sea. Eur. J. Clin. Nutr. 52, 7-11.
23. Refsum H (2001): Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome. Br. J. Nutr. 85(Suppl 2), S109-S113.
24. Saw SM, Yuan JM, Ong CN, Arakawa K, Lee HP, Coetzee GA & Yu MC (2001): Genetic, dietary, and other lifestyle determinants of plasma homocysteine concentrations in middle-aged and older Chinese men and women in Singapore. Am. J. Clin. Nutr. 73, 232-239.
25. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW & Wolf PA (2002): Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N. Eng. J. Med. 346, 476-483.
26. Smith D (2002): Homocysteine, B vitamins, and cognitive deficit in the elderly. Am. J. Clin. Nutr. 75, 785-786.
27. Stolzenberg-Solomon RZ, Miller ER III, Maguire MG, Selhub J & Appel LJ (1999): Association of dietary protein intake and coffee consumption with serum homocysteine concentrations in an older population. Am. J. Clin. Nutr. 69, 467-475.
28. Sorensen TK, Malinow MR, Williams MA, King IB & Luthy DA (1999): Elevated second-trimester serum homocyst(e)ine levels and subsequent risk of preeclampsia. Gynecol. Obstet. Invest. 48, 98-103.
29. Svenska Näringsrekommendationer (Swedish recommended dietary allowances) (1997): National Food Administration, Uppsala.
30. Ubbink JB, Vermaak WJ, van der Merwe A, Becker PJ, Delport R & Potgieter HC (1994): Vitamin requirements for the treatment of hyperhomocysteinemia in humans. J. Nutr. 124, 1927-1933.
31. Ubbink JB & Delport R (2000): Homocysteine as atherothrombotic agent: is the bark worse than the bite? Nutrition 16, 672-674.
32. Ueland PM, Refsum H, Beresford SA & Vollset SE (2000): The controversy over homocysteine and cardiovascular risk. Am. J. Clin. Nutr. 72, 324-332.
33. Urgert R, van Vliet T, Zock PL & Katan MB (2000): Heavy coffee consumption and plasma homocysteine: a randomized controlled trial in healthy volunteers. Am. J. Clin. Nutr. 72, 1107-1110.
34. van Guldener C & Stehouwer CD (2001): Homocysteine-lowering tretment: an overview. Expert. Opin. Pharmacol. 2, 1449-1460.
35. Vollset SE, Nygard O, Refsum H & Ueland PM (2000a): Coffee and homocysteine. Am. J. Clin. Nutr 71, 403-404.
36. Vollset SE, Refsum H, Irgens LM, Emblem RM, Tverdal A, Gjessing HK, Monsen AL & Ueland PM (2000b): Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine study. Am. J. Clin. Nutr. 71, 962-968.
37. Wald DS, Bishop L, Wald NJ, Law M, Hennessy E, Weir D, McPartlin J & Scott J (2001): Randomized trial of folic acid supplementation and serum homocysteine levels. Arch. Intern. Med. 161, 695-700.
38. Wouters MG, Boers GH, Blom HJ, Trijbels FJ, Thomas CM, Borm GF, Steegers-Theunissen RP & Eskes TK (1993): Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss. Fertil. Steril. 60, 820-825.