Inhibition of endothelial cell proliferation by the recombinant kringle domain of tissue-type plasminogen activator

Biochemical and Biophysical Research Communications

Volumn 304, Issue 4, 2003, Pages 740-746

  Kim, Hyun Kyung ^a   Lee, Soo Young ^b   Oh, Ho Kyun ^a   Kang, Byoung Hak ^a   Ku, Hyeun Ju ^a   Lee, Yoon ^a   Shin, Joo Young ^a   Hong, Yong Kil ^a   Joe, Young Ae ^a  

^a The Catholic University of Korea   (South Korea)

^b The Catholic University of Korea   (South Korea)

Author keywords

Angiogenesis; Inhibitor; Kringle; Proliferation; Tissue type plasminogen activator

Indexed keywords

ANGIOGENESIS INHIBITOR; ANGIOSTATIN; ANTIMITOTIC AGENT; ENZYME PRECURSOR; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; PLASMIN; PLASMINOGEN; TISSUE PLASMINOGEN ACTIVATOR; VASCULOTROPIN;

AMINO ACID SEQUENCE; ANGIOGENESIS; ANIMAL CELL; ARTICLE; BACTERIUM; CELL PROLIFERATION; CHICK EMBRYO; CHORIOALLANTOIS; CONTROLLED STUDY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG STRUCTURE; EMBRYO; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; KRINGLE DOMAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; STIMULATION; YEAST;

BACTERIA (MICROORGANISMS);

EID: 0242417496     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00656-9     Document Type: Article

References (36)

1. Bussolino F., Mantovani A., Persico G. Molecular mechanisms of blood vessel formation. Trends Biochem. Sci. 22:1997;251-256.
2. O'Reilly M.S., Shing Y., Chen C., Rosenthal R.A., Moses M., Lane W.S., Cao Y., Folkman J. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell. 79:1994;315-328.
3. O'Reilly M.S., Chen C., Folkman J. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat. Med. 2:1996;689-692.
4. Folkman J. Angiogenesis inhibitors generated by tumors. Mol. Med. 1:1995;120-122.
5. Kim K.J., Winer J., Armanini M., Gillett N., Phillips H.S., Ferrara N. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature. 362:1993;841-844.
6. Brooks P.C., Rosenfeld M., Reisfeld R.A., Hu T., Klier G., Cheresh D.A. Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell. 79:1994;1157-1164.
7. Good D., Polverini P., Rastinejad F., Beau M., Lemons R., Frazier W., Bouck N. A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin. Proc. Natl. Acad. Sci. USA. 87:1990;6624-6628.
8. Cao Y., Davidson D., Schaller J., Marti D., Sohndel S., McCance S.G., O'Reilly M.S., Folkman J. Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells. J. Biol. Chem. 271:1996;29461-29467.
9. Castellino F.J. The genetic relationships between the kringle domains of human plasminogen, prothrombin, tissue plasminogen activator, urokinase, and coagulation factor XII. J. Mol. Evol. 26:1987;358-369.
10. Castellino F.J., Powell J.R., Strickland D.K. The existence of independent domain structures in human Lys77-plasminogen. J. Biol. Chem. 256:1981;4778-4782.
11. Trexler M. Folding autonomy of the kringle 4 fragment of human plasminogen. Proc. Natl. Acad. Sci. USA. 80:1983;2457-2461.
12. Novokhatny V.V., Privalov P.L. Domains in human plasminogen. J. Mol. Biol. 179:1984;215-232.
13. Cao Y., An S.S., Ji R.W., Davidson D., Llinas M. Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth. J. Biol. Chem. 272:1997;22924-22928.
14. Lee T.H., Rhim T., Kim S.S. Prothrombin kringle-2 domain has a growth inhibitory activity against basic fibroblast growth factor-stimulated capillary endothelial cells. J. Biol. Chem. 273:1998;28805-28812.
15. Xin L., Zhang Q., Li T.P., Gan R.B. Kringle 1 of human hepatocyte growth factor inhibits bovine aortic endothelial cell proliferation stimulated by basic fibroblast growth factor and causes cell apoptosis. Biochem. Biophys. Res. Commun. 277:2000;186-190.
16. Lou X.J., Kwan H.H., Prionas S.D., Yang Z.J., Lawn R.M., Fajardo L.F. Despite its homology to angiostatin apolipoprotein(a) does not affect angiogenesis. Exp. Mol. Pathol. 65:1998;53-63.
17. Trieu V.N., Uckun F.M. Apolipoprotein(a), a link between atherosclerosis and tumor angiogenesis. Biochem. Biophys. Res. Commun. 257:1999;714-718.
18. Ji W.R., Chang Y., Deford M.E., Gray H., Villarreal X., Kondri M.E., Marti D.N., Schaller J., Kramer R.A., Trail P.A. Characterization of kringle domains of angiostatin as antagonists of endothelial cell migration, an important process in angiogenesis. FASEB J. 12:1998;1731-1738.
19. Bachman F. Molecular aspects of plasminogen, plasminogen activators and plasmin. Bloom A.L., Forbes C.D., Thomas D.P., Tuddenham E.G.D. Haemostasis and Thrombosis. 1994;575-613 Churchill Livingstone, Singapore.
20. Kirsch M., Allende R., Bello L., Zhang J., Black P.M. Angiostatin suppresses malignant glioma growth in vivo. Cancer Res. 58:1998;4654-4659.
21. Jaffe E.A., Nachman R.L., Becker C.G., Minick R. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J. Clin. Invest. 52:1973;2745-2756.
22. Kim H.J., Park J.S. Investigation of hydroxyl radical induced cross-linking of peptides and its inhibition by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Bull. Korean Chem. Soc. 20:1999;370-372.
23. Nguyen M., Folkman J. Quantitation of angiogenesis and antiangiogenesis in the chick embryo chorioallantoic membrane. Microvasc. Res. 47:1994;31-40.
24. Sohndel S., Marti D., Affolter M., Schaller J., Llinas M., Rickli E.E. Recombinant gene expression and 1H NMR characteristics of the kringle (2. + 3) supermodule: spectroscopic/functional individuality of plasminogen kringle domains Biochemistry. 35:1996;2357-2364.
25. Pennica D., Holmes W.E., Kohr W.J., Harkins R.N., Vehar G.A., Ward C.A., Bennett W.F., Yelverton E., Seeburg P.H., Heyneker H.L., Goeddel D.V., Collen D. Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli. Nature. 301:1983;214-221.
26. Patthy L. Evolution of the proteases of blood coagulation and fibrinolysis by assembly from modules. Cell. 41:1985;657-663.
27. Lee H.S., Lee J.H., You W.K., Chung S.I., Chang S.I., Park M.H., Hong Y.K., Joe Y.A. Disruption of interkringle disulfide bond of plasminogen kringle 1-3 changes the lysine binding capability of kringle 2, but not its antiangiogenic activity. Arch. Biochem. Biophys. 375:2000;359-363.
28. Moser T.L., Kenan D.J., Ashley T.A., Roy J.A., Goodman M.D., Misra U.K., Cheek D.J., Pizzo S.V. Endothelial cell surface F1-FO ATP synthase is active in ATP synthesis and is inhibited by angiostatin. Proc. Natl. Acad. Sci. USA. 98:2001;6656-6661.
29. Troyanovsky B., Mansson G., Matvijenko O., Holmgren L. Angiomotin: an angiostatin binding protein that regulates endothelial cell migration and tube formation. J. Cell Biol. 152:2001;1247-1254.
30. Claesson-Welsh L., Welsh M., Ito N., Anand-Apte B., Soker S., Zetter B., O'Reilly M.S., Folkman J. Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD. Proc. Natl. Acad. Sci. USA. 95:1998;5579-5583.
31. Lucas R., Garcia I., Jimenez B., Mandriota S.J., Borlat F., Sim B.K., Wu Z., Grau G.E., Shing Y., Soff G.A., Bouck N., Pepper M.S. Multiple forms of angiostatin induce apoptosis in endothelial cells. Blood. 92:1998;4730-4741.
32. Griscelli F., Bennaceur-Griscelli A., Soria J., Opolon P., Soria C., Perricaudet M., Yeh P., Lu H. Angiostatin gene transfer: inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest. Proc. Natl. Acad. Sci. USA. 95:1998;6367-6372.
33. Tarui T., Takada Y. Specific interaction of angiostatin with integrin alpha(v)beta(3) in endothelial cells. J. Biol. Chem. 276:2001;39562-39568.
34. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1:1995;27-31.
35. O'Reilly M.S., Shing Y., Fukai N., Vasios G., Lane W.S., Flynn E., Birkhead J.R., Folkman J. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell. 88:1997;277-285.
36. Bergers G., Lo K.M., Folkman J., Hanahan D. Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science. 284:1999;808-812.