A Randomized Trial of Eutectic Mixture of Local Anesthetics during Lumbar Puncture in Newborns

Archives of Pediatrics and Adolescent Medicine

Volumn 157, Issue 11, 2003, Pages 1065-1070

  Kaur, Geetinder ^a   Gupta, Piyush ^a,b   Kumar, Ashok ^a  

^a UNIVERSITY COLLEGE OF MEDICAL SCIENCES   (India)

^b Near Telephone Exchange   (India)

Author keywords

[No Author keywords available]

Indexed keywords

EMLA; PLACEBO;

ANALGESIA; ANALYSIS OF VARIANCE; ARTICLE; CHILD BEHAVIOR; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREAM; DIAGNOSTIC PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; GESTATIONAL AGE; HEART RATE; HUMAN; LOCAL ANESTHESIA; LUMBAR PUNCTURE; MAJOR CLINICAL STUDY; MALE; NEEDLE; NEWBORN; NEWBORN INTENSIVE CARE; OUTCOMES RESEARCH; OXYGEN SATURATION; PAIN; PAIN ASSESSMENT; PATIENT CODING; PEDIATRIC ANESTHESIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SIDE EFFECT; SKIN MANIFESTATION; STATISTICAL SIGNIFICANCE; TELEVISION CAMERA; TOPICAL ANESTHESIA; TRANSCUTANEOUS OXYGEN MONITORING; UNIVERSITY HOSPITAL; VIDEORECORDING;

ANESTHETICS, COMBINED; ANESTHETICS, LOCAL; CHI-SQUARE DISTRIBUTION; DOUBLE-BLIND METHOD; HUMANS; INFANT, NEWBORN; INTENSIVE CARE UNITS, NEONATAL; LIDOCAINE; LUMBAR VERTEBRAE; PAIN; PAIN MEASUREMENT; PRILOCAINE; SPINAL PUNCTURE; STATISTICS, NONPARAMETRIC; TREATMENT OUTCOME;

EID: 0242408716     PISSN: 10724710     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpedi.157.11.1065     Document Type: Article

References (19)

1. Anand KJS, Hickey PR. Pain and its effects in the human neonate and fetus. N Engl J Med. 1987;317:1321-1329.
2. Anand KJS, Scalzo FM. Can adverse neonatal experiences alter brain development and subsequent behavior? Biol Neonate. 2000;77:69-82.
3. Barker DP, Rutter N. Exposure to invasive procedures in neonatal intensive care unit admissions. Arch Dis Child Fetal Neonatal Ed. 1995;72:F47-F48.
4. Anand KJS. Physiology of pain in infants and children. Ann Nestle [Fr]. 1999;57:1-12.
5. Lidow MS. Long-term effects of neonatal pain on nociceptive systems. Pain. 2002;99:377-383.
6. Gajraj NM, Pennant JH, Watcha MF. Eutectic mixture of local anesthetics (EMLA) cream. Anesth Analg. 1994;78:574-583.
7. Taddio A, Stevens B, Craig K, et al. Efficacy and safety of lidocaine-prilocaine cream for pain during neonatal circumcision. N Engl J Med. 1997;336:1197-1201.
8. Benini F, Johnston CC, Faucher D, Aranda JV. Topical anesthesia during circumcision in newborn infants. JAMA. 1993;270:850-853.
9. Gourrier E, Karoubi P, El Hanache A, et al. Use of EMLA cream in premature and full-term newborn infants. Arch Pediatr. 1995;2:1041-1046.
10. Garcia OC, Reichberg S, Brion LP, Schulman M. Topical anesthesia with EMLA during percutaneous line insertion in very low birth weight infants [abstract]. Pediatr Res. 1995;37:205A.
11. Taddio A, Ohlsson A, Einarson TR, Stevens B, Koren G. A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates. Pediatrics. 1998;101:1-9.
12. Halperin DL, Koren G, Attias D, Pellegrini E, Greenberg ML, Wyss M. Topical skin anesthesia for venous, subcutaneous drug reservoir and lumbar punctures in children. Pediatrics. 1989;84:281-284.
13. Kapelushnik J, Koren G, Solh H, Greenberg M, De Veber L. Evaluating the efficacy in alleviating pain associated with lumbar puncture. Pain. 1990;42:31-34.
14. Giminez JJC, Oliveras M, Hidalgo E, et al. Anesthetic efficacy of eutectic prilocainelidocaine cream in pediatric oncology patients undergoing lumbar puncture. Ann Pharmacother. 1996;30:1235-1237.
15. Enad D, Salvador A, Brodsky NL, Hurt H. Safety and efficacy of eutectic mixture of local anesthetics (EMLA) for lumbar puncture in newborns [abstract]. Pediatr Res. 1995;37:204A.
16. Grunau RVE, Craig KD. Pain expression in neonates. Pain. 1987;28:395-410.
17. Rushforth JA, Levene MI. Behavioral response to pain in healthy neonates. Arch Dis Child Fetal Neonatal Ed. 1994;70:F174-F176.
18. Indrayan A, Gupta P. Sampling techniques, confidence intervals, and sample size. Natl Med J India. 2000;13:29-36.
19. Porter FL, Wolf CM, Miller JP. The effect of handling and immobilization on the response to acute pain in newborn infants. Pediatrics. 1998;102:1383-1389.