Corey-Chaykovsky Reaction of Chiral Sulfinyl Imines: A Convenient Procedure for the Formation of Chiral Aziridines

Synlett

Volumn , Issue 13, 2003, Pages 1985-1988

  Morton, Daniel ^a   Pearson, David ^b   Field, Robert A ^a   Stockman, Robert A ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b Millennium Pharmaceuticals Ltd   (United Kingdom)

Author keywords

Aziridine; Corey chaykovsky; Imine; Sulfinyl imine; Ylide

Indexed keywords

AZIRIDINE DERIVATIVE; DIMETHYLSULFONIUM METHYLIDE; HETEROCYCLIC COMPOUND; IMINE; METHYL GROUP; SULFINYLIMINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHIRALITY; COREY CHAYKOVSKY REACTION; CRYSTAL STRUCTURE; OPTICAL ROTATION; STEREOCHEMISTRY; STRUCTURE ANALYSIS; SYNTHESIS;

EID: 0242383439     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-42028     Document Type: Article

References (8)

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2. (b) García Ruano, J. L.; Fernández, I.; del Prado Catalina, M.; Cruz, A. A. Tetrahedron: Asymmetry 1996, 7, 3407.
3. Davis, F. A.; Zhou, P.; Liang, C-H.; Reddy, R. E. Tetrahedron: Asymmetry 1995, 6, 1511.
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6. 4, and concentrated under reduced pressure. Purification by column chromatography on alumina (Brockmann grade 3) eluting with hexanes-EtOAc gave the products.
7. 3): δ = 14.2, 22.8, 23, 25.8, 26.2, 28.8, 31.8, 36.3, 57.
8. Fletcher, D. A.; McMeeking, R. F.; Parkin, D. J. Chem. Inf. Comput. Sci. 1996, 36, 746.