A Practical Parallel Synthesis of 2-Substituted Indolizines

Synlett

Volumn , Issue 13, 2003, Pages 2086-2088

  Chai, Wenying ^a   Kwok, Annette ^a   Wong, Victoria ^a   Carruthers, Nicholas I ^a   Wu, Jiejun ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Hydrogenation; Indolizidine; Indolizine; Parallel synthesis; Tschitschibabin indolizine synthesis

Indexed keywords

INDOLIZINE DERIVATIVE;

ARTICLE; CHEMICAL MODIFICATION; CRYSTALLIZATION; CYCLIZATION; PHASE SEPARATION; REDUCTION; SYNTHESIS;

EID: 0242383403     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-42042     Document Type: Article

References (12)

1. (a) Uchida, T.; Matsumoto, K. Synthesis 1976, 4, 209.
2. (b) Swinbourne, F. J.; Hunt, J. H.; Klinkert, G. Adv. Heterocycl. Chem. 1978, 23, 103.
3. Goff, D. A. Tetrahedron Lett. 1999, 40, 8741.
4. (a) Zhang, L.; Liang, F.; Sun, L.; Hu, Y.; Hu, H. Synthesis 2000, 12, 1733.
5. (b) Zaporozhets, O. B.; Ryashentseva, M. A.; Polosin, V. M.; Poponova, R. V. Russ. Chem. Bull. 1993, 42, 1209.
6. (a) Tschitschibabin, A. Ber. Dtsch. Chem. Ges. 1927, 60, 1607.
7. (b) Kostik, E. I.; Abiko, A.; Oku, A. J. Org. Chem. 2001, 66, 2618.
8. (a) Sonnet, P. E.; Oliver, J. E. J. Heterocycl. Chem. 1975, 12, 289.
9. (b) Colegate, S. M.; Dorling, P. R.; Huxtable, C. R. Aust. J. Chem. 1979, 32, 2257.
10. (c) Chastanet, J.; Roussi, G. J. Org. Chem. 1985, 50, 2910.
11. Galbraith, A.; Small, T.; Barnes, R. A.; Boekelheide, V. J. Am. Chem. Soc. 1961, 83, 453.
12. Lins, C. L. K.; Block, J. H.; Doerge, R. F. J. Pharm. Sci. 1982, 71, 556.