The Neuroexcitatory Morphine Metabolite, Morphine-3-glucuronide (M3G), is not Neurotoxic in Primary Cultures of either Hippocampal or Cerebellar Granule Neurones

Pharmacology and Toxicology

Volumn 93, Issue 4, 2003, Pages 197-200

  Hemstapat, Kamondanai ^a   Smith, Steven A ^a   Monteith, Gregory R ^a   Smith, Maree T ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; MORPHINE; MORPHINE 3 GLUCURONIDE; NALOXONE;

ALLODYNIA; ANIMAL BEHAVIOR; ANIMAL CELL; ARTICLE; BRAIN REGION; CANCER PAIN; CEREBELLUM; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EXPOSURE; DRUG MECHANISM; EMBRYO; GRANULE CELL; HIPPOCAMPUS; MYOCLONUS; NERVE CELL CULTURE; NERVE CELL EXCITABILITY; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM STIMULANTS; CEREBELLUM; EMBRYO; FEMALE; GLUTAMIC ACID; HIPPOCAMPUS; MORPHINE; MORPHINE DERIVATIVES; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

ANIMALIA; HIPPOCAMPUS HIPPOCAMPUS;

EID: 0242383349     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0773.2003.930408.x     Document Type: Article

References (22)

1. Bartlett, S. E., T. Cramond & M. T. Smith: The excitatory effects of morphine-3-glucuronide are attenuated by LY274614, a competitive NMDA receptor antagonist, and by midazolam, an agonist at the benzodiazepine site on the GABAA receptor complex. Life Sci. 1994, 54, 687-694.
2. Brewer, G. J., J. R. Torricelli, E. K. Evege & P. J. Price: Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J. Neurosci. Res. 1993, 35, 567-576.
3. Cheung, N. S., C. J. Pascoe, S. F. Giardina, C. A. John & P. M. Beart: Micromolar L-glutamate induces extensive apoptosis in an apoptotic-necrotic. Neuropharmacology 1998, 37, 1419-1429.
4. Choi, D. W.: Ionic dependence of glutamate neurotoxicity. J. Neurosci. 1987, 7, 369-379.
5. Choi, D. W., J. Y. Koh & S. Peters: Pharmacology of glutamate neurotoxicity in cortical cell culture. J. Neurosci. 1988, 8, 185-196.
6. Halliday, A. J., S. E. Bartlett, P. Colditz & M. T. Smith: Brain region-specific studies of the excitatory behavioral effects of morphine-3-glucuronide. Life Sci. 1999, 65, 225-236.
7. Hemstapat, K., G. R. Monteith, D. Smith & M. T. Smith: Morphine-3-glucuronide's neuro-excitatory effects are mediated via indirect activation of NMDA receptors: mechanistic studies in embryonic cultured hippocampal neurones. Anesth. Analg. 2003, 97, 494-505.
8. Koh, J. Y. & D. W. Choi: Quantitative determination of glutamate mediated cortical neuronal injury. J. Neurosci. Meth. 1987, 20, 83-90.
9. Lee, M. M., M. T. Hseih, J. S. Kuo, F. T. Yeh & H. M. Huang: Magnolol protects cortical neuronal cells from chemical hypoxia in rats. Neuroreport 1998, 9, 3451-3456.
10. Lobner, D: Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis? J. Neurosci. Meth. 2000, 96, 147-152.
11. Mattson, M. P., J. N. Keller & J. G. Begley: Evidence for synaptic apoptosis. Exp. Neurol. 1998, 153, 35-48.
12. Miller, T. M. & E. M. Johnson, Jr.: Metabolic and genetic analyses of apoptosis in potassium/serum-deprived rat. J. Neurosci. 1996, 16, 7487-7495.
13. Sattler, R. & M. Tymianski: Molecular mechanisms of calcium-dependent excitotoxicity. J. Mol. Med. 2000, 78, 3-13.
14. Shen, M. & S. A. Thayer: Cannabinoid receptor agonists protect cultured rat hippocampal neurons from excitotoxicity. Mol. Pharmacol. 1998, 54, 459-462.
15. Smith, M. T.: Neuroexcitatory effects of morphine and hydromorphone: evidence implicating the 3-glucuronide metabolites. Clin. Exp. Pharmacol Physiol. 2000, 27, 524-528.
16. Smith, S. A., F. J. May, G. R. Monteith & S. J. Roberts Thomson: Activation of the peroxisome proliferator-activated receptor-alpha enhances. J. Neurosci. Res. 2001, 66, 236-241.
17. Suuronen, T., P. Kolehmainen & A. Salminen: Protective effect of L-deprenyl against apoptosis induced by okadaic acid in cultured neuronal cells. Biochem. Pharmacol. 2000, 59, 1589-1595.
18. Tabuchi, A., K. Funaji, J. Nakatsubo, M. Fukuchi, T. Tsuchiya & M. Tsuda: Inactivation of aconitase during the apoptosis of mouse cerebellar granule neurons induced by a deprivation of membrane depolarization. J. Neurosci. Res. 2003, 71, 504-515.
19. Uryu, S., J. Harada, M. Hisamoto & T. Oda: Troglitazone inhibits both post-glutamate neurotoxicity and low-potassium-induced apoptosis in cerebellar granule neurons. Brain Res. 2002, 924, 229-236.
20. Yamagishi, S., M. Yamada, Y. Ishikawa, T. Matsumoto, T. Ikeuchi & H. Hatanaka: p38 mitogen-activated protein kinase regulates low potassium-induced c-Jun. J. Biol. Chem. 2001, 276, 5129-5133.
21. Yamaguchi, A., M. Tamatani, H. Matsuzaki, K. Namikawa, H. Kiyama, M. P. Vitek, N. Mitsuda & M. Tohyama: Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. J. Biol. Chem. 2001, 276, 5256-5264.
22. Zhao, X. R., B. Bausano, B. R. Pike, J. K. Newcomb-Fernandez, K. K. W. Wang, E. Shohami, N. C. Ringger, S. M. DeFord, D. K. Anderson & R. L. Hayes: TNF-alpha stimulates caspase-3 activation and apoptotic cell death in primary septo-hippocampal cultures. J. Neurosci. Res. 2001, 64, 121-131.