Suppressive Effect of Iron on Concanavalin A-Induced Multinucleated Giant Cell Formation by Human Monocytes

Immunological Investigations

Volumn 32, Issue 4, 2003, Pages 229-243

  Tahara, Kiyoshi ^a   Nishiya, Koji ^a,b   Hisakawa, Naoko ^a   Wang, Honggang ^a   Hashimoto, Kozo ^a  

^a KOCHI MEDICAL SCHOOL   (Japan)

^b Nishiya Naika   (Japan)

Author keywords

Concanavalin A; Desferrioxamine; Human monocyte; Iron; Multinucleated giant cell

Indexed keywords

BETA2 INTEGRIN; CD18 ANTIGEN; CD2 ANTIGEN; CITRATE SODIUM; CONCANAVALIN A; DEFEROXAMINE; FERRIC CITRATE; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; IRON; IRON CHELATING AGENT; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

ANTIGEN EXPRESSION; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GIANT CELL; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IRON OVERLOAD; MICROSCOPY; MONOCYTE; NATURAL KILLER CELL; PHAGOCYTOSIS; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL; VENOUS BLOOD;

EID: 0242381251     PISSN: 08820139     EISSN: None     Source Type: Journal    
DOI: 10.1081/IMM-120025103     Document Type: Article

References (36)

1. Akagawa, K., Takasuka, N., Nozaki, Y., Komuro, I., Azuma, M., Ueda, M., Naito, M., Takahashi, K. (1996). Generation of CD1 + RelB + dendritic cells and tartrate-resistant acid phosphatase-positive osteoclast-like multinucleated giant cells from human monocytes. Blood 88:4029-4039.
2. Ballart, I. J., Estevez, M. E., Sen, L., Diez, R. A., Giuntoli, J., de Miani, S. A., Penalver, J. (1986). Progressive dysfunction of monocytes associated with iron overload and age in patients with thalassemia major. Blood 67:105-109.
3. Bryan, C. F., Nishiya, K., Pollak, M. S., Dupont, B., De Sousa, M. (1981). Differential inhibition of the MLR by iron: association with HLA phenotype. Immunogenetics 12:129-140.
4. Byrd, T. F. (1997). Tumor necrosis factor α(TNF α) promotes growth of virulent Mycobacterium tuberculosis in human monocytes. J. Clin. Invest. 99:2518-2529.
5. Byrd, T. F. (1998). Multinucleated giant cell formation induced by IFN-τ/1L-3 is associated with restriction of virulent Mycobacterium tuberculosis cell to cell invasion in human monocyte monolayers. Cell. Immunol. 188:89-96.
6. Cairo, G., Recalcati, S., Montosi, G., Castrusini, E., Conte, D., Pietrangelo, A. (1997). Inappropriately high iron regulatory protein activity in monocytes of patients with genetic hemochromatosis. Blood 89:2546-2553.
7. Cardier, J. E., Romano, E., Soyano, A. (1997). T lymphocytes subsets in experitemtal iron overload. Immunopharmacol Immunotoxicol. 19:75-87.
8. Carvalho, G. S., De Sousa, M. (1988). Iron exerts a specific inhibitory effect on CD2 expression of human PBL. Immunol. Lett. 19:163-168.
9. Chambers, T. J. (1978). Multinucleated giant cells. J. Pathol. 126:125-148.
10. De Sousa, M. (1989). Immune cell functions in iron overload. Clin. Exp. Immunol. 75:1-6.
11. Enelow, R. I., Sullivan, G. W., Carper, H. T., Mandell, G. L. (1992). Cytokine-induced human multinucleated giant cells have enhanced candidacidal activity and oxidative capacity compared with macrophages. J. Infect. Dis. 166:664-668.
12. Fan, L., Iyer, J., Zhu, S., Frick, K. K., Wada, R. K., Eskenazi, A. E., Berg, P. E., Ikegaki, N., Kennett, R. H., Frantz, C. N. (2001). Inhibition of N-myc expression and induction of apoptosis by iron chalation in human neuroblastoma cells. Cancer Res. 61:1073-1079.
13. Fujikawa, Y., Sabokbar, A., Neale, S., Athanasou, N. A. (1996). Human osteoclast formation and bone resorption by monocytes and synovial macrophages in rheumatoid arthritis. Ann. Rheum. Dis. 55:816-822.
14. Gordeuk, V. R., Ballou, S., Lozanski, G., Brittenham, G. M. (1992). Decreased concentrations of tumor necrosis factor-α in supernatants of monocytes from homozygotes for hereditary hemochromatosis. Blood 79:1855-1860.
15. Hassan, N. F., Kamani, N., Meszaros, M. M., Douglas, S. D. (1989). Induction of multinucleated giant cell formation from human blood-derived monocytes by phorbol myristate acetate in in vitro culture. J. Immunol. 143:2179-2184.
16. Hisakawa, N., Nishiya, K., Tahara, K., Matsumori, A., Hashimoto, K. (1998). Down regulation by iron of prostaglandin E2 production by human synovial fibroblasts. Ann. Rheum. Dis. 57:742-746.
17. Hoen, B. (1999). Iron and infection: clinical experience. Am. J. Kidney Dis. 34(Suppl 2):S30-S34.
18. Jurado, R. L. (1997). Iron, infections, and anemia of inflammation. Clin. Infect. Dis. 25:888-895.
19. Mc Nally, A. K., Anderson, J.M. (1995). Interleukin-4 induces foreign body giant cells from human monocytes/macrophages. Differential lymphokine regulation of macrophage fusion leads to morphological variants of multinucleated giant cells. Am. J. Pathol. 147:1487-1499.
20. Most, J., Neumayer, H. P., Dierich, M. P. (1990). Cytokine-induced generation of multinucleated giant cells in vitro requires interferon-τ and expression of LFA-1. Eur. J. Immunol. 20:1661-1667.
21. Moura, E., Verheul, A. F. M., Marx, J. J. M. (1998). A functional defect in hereditary haemochromatosis monocytes and monocyte-derived macrophages. Eur J. Clin. Investig. 28:164-173.
22. Nishiya, K. (1994). Stimulation of human synovial cell DNA synthesis by iron. J. Rheumatol. 21:1802-1807.
23. Nishiya, K., Horwitz, D. A. (1982). Contrasting effects of lactoferrin on human lymphocyte and monocyte natural killer activity and antibody- dependent cell-mediated cytotoxicity. J. Immunol. 129:2519-2523.
24. Nishiya, K., De Sousa, M., Tsoi, E., Bognacki, J. J., De Harven, E. (1980). Regulation of expression of a human lymphoid cell surface marker by iron. Cell. Immunol. 53:71-83.
25. Nishiya, K., Matsueda, H., Watanabe, T., Suzuki, S., Ota, Z. (1989). Inhibitory effect of iron on Fc- and C3-receptor expression of human monocytes. Jpn. J. Clin. Immunol. 12:202-208.
26. Nishiya, K., Wang, H., Tahara, K., Hashimoto, K. (2003). Enhancement by iron of interleukinl induced granulocyte macrophage colony stimulating factor (GM-CSF) production by human synovial fibroblasts. Ann. Rheum. Dis. 62:89-90.
27. Santos, M., De Sousa, M. (1994). In vitro modulation of T-cell surface molecules by iron. Cell. Immunol. 154:498-506.
28. Schlesinger, L., Musson, R. A., Johnston, R. B. (1984). Functional and biochemical studies of multinucreated giant cells derived from the culture of human monocytes. J. Exp. Med. 159:1289-1294.
29. Takashima, T., Ohnishi, K., Tsuyuguchi, I., Kishimoto, S. (1993). Differential regulation of formation of multinucleated giant cells from Concanavalin A-stimulated human blood monocytes by IFN-τ 7 and IL-4. J. Immunol. 150:3002-3010.
30. Van Asbeck, B. S., Verbrugh, H. A., Van Oost, B. A., Marx, J. J., Imhof, H. W., Verhoef, J. (1982). Listeria monocytogenes meningitis and decreased phagocytosis associated with iron overload. Br. Med. J. 284:542-544.
31. Vignery, A. (2000). Osteoclasts and giant cells: macrophage-macrophage fusion mechanism, Int. J. Exp. Pathol. 81:291-304.
32. Weinberg, J. B., Hibbs, J. B. (1977) Endocytosis of red blood cells or haemoglobin by activated macrophages inhibits their tumoricidal effect. Nature 269:245-247.
33. Weiss, G., Werner-Felmayer, G., Werner, E. R., Grunewald, K., Wachter, H., Hentze, M. W. (1994). Iron regulates nitric oxide synthase activity by controlling nuclear transcription. J. Exp. Med. 180:969-974.
34. Weiss, G., Bogdan, C., Hentze, M. W. (1997a). Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13. J. Immunol. 158:420-425.
35. Weiss, G., Kastner, S., Brock, J., Thaler, J., Grunewald, K. (1997b). Modulation of transferrin receptor expression by dexrazoxane (ICRF-187) via activation of iron regulatory protein. Biochem. Pharmacol 53:1419-1424.
36. Weiss, G., Thuma, P. E., Mabeza, G., Wemer, E. R., Herold, M., Gordeuk, V. R. (1997c). Modulatory potential of iron chelation therapy in nitric oxide formation on cerebral malaria. J. Infect. Dis. 175:226-230.