The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34

Gene

Volumn 318, Issue 1-2, 2003, Pages 149-161

  Holden, Simon ^a   Raymond, F Lucy ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

BC012177; C9orf10; Chromosome Xp11.2; Transmembrane domain

Indexed keywords

COMPLEMENTARY DNA; MEMBRANE PROTEIN;

ADULT; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; BRAIN; CARBOXY TERMINAL SEQUENCE; CENTROMERE; CONTROLLED STUDY; EUKARYOTE; EXON; FETUS; GENE EXPRESSION; GENETIC CODE; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORTHOLOGY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TELOMERE; X CHROMOSOME;

CHORDATA; EUKARYOTA;

EID: 0242380266     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(03)00770-4     Document Type: Article

References (21)

1. Assink J.J., Tijmes N.T., ten Brink J.B., Oostra R.J., Riemslag F.C., de Jong P.T., Bergen A.A. A gene for X-linked optic atrophy is closely linked to the Xp11.4-Xp11.2 region of the X chromosome. Am. J. Hum. Genet. 61:1997;934-939.
2. Boycott K.M., Zahorchak R.J., Summer C.G., Boycott N.P., Kotak V., Russell C.G., Bech-Hansen N.T. Construction of a 1.5-Mb bacterial artificial chromosome contig in Xp11.23, a region of high gene content. Genomics. 48:1998;369-372.
3. Burney E., Bateman A., Clamp E., Hubbard T. Mining the draft human genome. Nature. 409:2001;827-828.
4. Chelly J. MRX review. Am. J. Med. Genet. 94:2000;364-366.
5. Cox J.J., Holden S.T., Dee S., Burbridge J.I., Raymond F.L. Identification of a 650 kb duplication at the X chromosome breakpoint in a patient with 46,X,t(X;8)(q28;q12) and non-syndromic mental retardation. J. Med. Genet. 40:2003;169-174.
6. Hofmann K., Stoffel W. TMBASE - a database of membrane spanning protein segments. Biol. Chem. 374:1993;166.
7. Jurka J., Klonowski P., Dagman V., Pelton P. CENSOR - a program for identification and elimination of repetitive elements from DNA sequences. Comput. Chem. 20:1996;119-122.
8. Kapitonov V.V., Jurka J. The long terminal repeat of an endogenous retrovirus induces alternative splicing and encodes an additional carboxy terminal sequence in the human leptin receptor. J. Mol. Evol. 48:1999;248-251.
9. Kobayashi H., Baumbach L., Matise T.C., Schiavi A., Greenberg F., Hoffman E.P. A gene for a severe lethal form of X-linked arthrogryposis (X-linked infantile spinal muscular atrophy) maps to human chromosome Xp11.3-q11.2. Hum. Mol. Genet. 4:1995;1213-1216.
10. Kozak M. Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. Nucleic Acids Res. 12:1984;857-872.
11. Kozak M. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell. 44:1986;283-292.
12. Lubs H., Chiurazzi P., Arena J., Schwartz C., Tranebjaerg L., Neri G. XLMR genes: update 1998. Am. J. Med. Genet. 83:1999;237-247.
13. Li W., Gu Z., Wang H., Nekrutenko A. Evolutionary analysis of the human genome. Nature. 409:2001;847-849.
14. Makalowski W. Genomic scrap yard: how genomes utilize all that junk. Gene. 259:2000;61-67.
15. Nekrutenko A., Li W. Transposable elements are found in a large number of human protein-coding genes. Trends Genet. 17:2001;619-621.
16. Persson B., Argos P. Prediction of transmembrane segments in proteins utilizing multiple sequence alignments. J. Mol. Biol. 237:1994;182-192.
17. Schindelhauer D., Hellebrand H., Grimm L., Bader I., Meitinger T., Wehnert M., Ross M., Meindl A. Long-range map of a 3.5-Mb region in Xp11.23-22 with a sequence-ready map from a 1.1-Mb gene-rich interval. Genome Res. 6:1996;1056-1069.
18. Smit A.F.A. Identification of a new, abundant superfamily of mammalian LTR-transposons. Nucleic Acids Res. 21:1993;1863-1872.
19. Sverdlov E.D. Perpetually mobile footprints of ancient infections in human genome. FEBS Lett. 428:1998;1-6.
20. Thiselton D.L., McDowall J., Brandau O., Ramser J., d'Esposito F., Bhattacharya S.S., Ross M.T., Hardcastle A.J., Meindl A. An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders. Genomics. 79:2002;560-572.
21. Wolfsberg T., Wetterstrand K., Guyer M., Collins F., Baxevanis A. A user's guide to the human genome. Nat. Genet. 32:2002;5-8. (Supplement).