Synthetic estrogen-mediated activation of ERK 2 intracellular signaling molecule

Gynecological Endocrinology

Volumn 17, Issue 5, 2003, Pages 423-428

  Prifti, S ^a   Mall, P ^a   Rabe, T ^a,b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Abt Gynaekologische Endokrinol F   (Germany)

Author keywords

Breast Cancer Cells; Intracellular Signalling; Map Kinase; Western Blot

Indexed keywords

ANTIESTROGEN; EPIDERMAL GROWTH FACTOR; ESTRADIOL; ESTRADIOL VALERATE; ESTROGEN; ESTROGEN RECEPTOR; ETHINYLESTRADIOL; FULVESTRANT; MITOGEN ACTIVATED PROTEIN KINASE 1;

ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER CELL CULTURE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ESTROGEN ACTIVITY; HORMONAL REGULATION; HORMONE ACTION; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL DIVISION; CELLS, CULTURED; EPIDERMAL GROWTH FACTOR; ESTRADIOL; ESTRADIOL CONGENERS; ETHINYL ESTRADIOL; FEMALE; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1;

EID: 0242364734     PISSN: 09513590     EISSN: None     Source Type: Journal    
DOI: 10.1080/09513590312331290338     Document Type: Article

References (25)

1. Roudabush FL, Pierce KL, Maudsley S, et al. Transactivation of the EGF receptor mediates IGF-1-stimulated She phosphorylation and ERK1/2 activation in COS-7 cells. J Biol Chem 2000; 275:22583-9
2. Cruzalegui FH, Cano E, Treisman R. ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry. Oncogene 1999;18: 7948-57
3. Boulton TG, Nye SH, Robbins DJ, et al. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 1991;65:663-75
4. Davis RJ. The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 1993;268: 14553-6
5. Alvarez E, Northwood IC, Gonzalez FA, et al. Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase. J Biol Chem 1991;266:15277-85
6. Arteaga CL, Johnson MD, Todderud G, et al. Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas. Proc Natl Acad Sci 1991;88:10435-9
7. Seger R, Krebs EG. The MAPK signaling cascade. FASEB J 1995;9:726-35
8. Oka H, Chatani Y, Hoshino R, et al. Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma. Cancer Res 1995;55:4182-7
9. Janes PW, Daly RJ, deFazio A, et al. Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2.Oncogene 1994;9: 3601-8
10. Mansour SJ, Matten WT, Hermann AS, et al. Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 1994;265:966-70
11. Clark GJ, Der CJ. Aberrant function of the Ras signal transduction pathway in human breast cancer. Breast Cancer Res Treat 1995;35:133-44
12. Kenney NJ, Dickson RB. Growth factor and sex steroid interactions in breast cancer. J Mammary Gland Biol Neoplasm 1996;1:189-98
13. Aronica SM, Kraus WL, Katzenellenbogen BS. Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription. Proc Natl Acad Sci 1994;91: 8517-21
14. Migliaccio A, Di Domenico M, Castoria G, et al. Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells. EMBO J 1996;15:1292-300
15. Gentry MK, Dalrymple JM. Quantitative microtiter cytotoxiciry assay for Shigella toxin. J Clin Microbiol 1980;12:361-6
16. Meink O, Lund E, Adami HO, et al. Oral contraceptives and breast cancer. Lancet 1986;2:1272-3
17. Qiu RG, Chen J, Kirn D, et al. An essential role for Rac in Ras transformation. Nature 1995;374:457-9
18. Migliaccio A, Di Domenico M, Castoria G, et al. Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells. EMBO J 1996;15:1292-300
19. Bunone G, Briand PA, Miksicek RJ, et al. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J 1996;15:2174-83
20. Iacopino F, Ferrandina G, Scambia G, et al. Interferons inhibit EGF-stimulated cell growth and reduce EGF binding in human breast cancer cells. Anticancer Res 1996;16:1919-24
21. Kasid A, Lippman ME. Estrogen and oncogene mediated growth regulation of human breast cancer cells. J Steroid Biochem 1987;27:465-70
22. Jordan VC (ed). Estrogen-Antiestrogen Action and Breast Cancer Therapy. Madison: University of Wisconsin Press, 1986:132-43
23. Santen RJ, Manni A, Harvey H, et al. Endocrine treatment of breast cancer in women. Endocr Rev 1990;11:221-65
24. Endoh H, Sasaki H, Maruyama K, et al. Rapid activation of MAP kinase by estrogen in the bone cell line. Biochem Biophys Res Commun 1997;235: 99-102
25. Watters JJ, Campbell JS, Cunningham MJ, et al. Rapid membrane effects of steroids in neuroblastoma cells: effects of estrogen on mitogen activated protein kinase signalling cascade and c-fos immediate early gene transcription. Endocrinology 1997;138:4030-3