Characterizing the influence of structure and route of exposure on the disposition of dithiocarbamates using toluene-3,4-dithiol analysis of blood and urinary carbon disulfide metabolites

Toxicological Sciences

Volumn 76, Issue 1, 2003, Pages 65-74

  Johnson, D J ^a,b   Amarnath, V ^a   Amarnath, K ^a   Valentine, H ^a   Valentine, W M ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b HAMPTON UNIVERSITY   (United States)

Author keywords

Carbon disulfide; Disulfiram; N,N diethyldithiocarbamate; N methydithiocarbamate; Pyrrolidine dithiocarbamate

Indexed keywords

CARBON DISULFIDE; CARBOXYLIC ACID DERIVATIVE; DIETHYLDITHIOCARBAMIC ACID; DISULFIRAM; DITHIOCARBAMIC ACID DERIVATIVE; GLOBIN; NITROGEN; PYRROLIDINE DITHIOCARBAMATE; TOLUENE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; BLOOD ANALYSIS; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; EXPOSURE; IN VIVO STUDY; MALE; NONHUMAN; OXIDATION; PROTEIN MODIFICATION; RAT; SENSITIVITY ANALYSIS; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; TOXICOKINETICS; URINALYSIS; URINARY EXCRETION;

ADMINISTRATION, ORAL; ANIMALS; CARBON DISULFIDE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; INJECTIONS, INTRAPERITONEAL; MALE; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; THIOCARBAMATES; TISSUE DISTRIBUTION; TOLUENE;

ANIMALIA;

EID: 0242363222     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg226     Document Type: Article

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