Pharmacokinetic and Pharmacological Interactions between Ticlopidine Hydrochloride and Kangen-Karyu - Chinese Traditional Herbal Medicine

Phytotherapy Research

Volumn 17, Issue 9, 2003, Pages 1021-1024

  Makino, Toshiaki ^a   Wakushima, Hannosuke ^a   Okamoto, Takuya ^a,b   Okukubo, Yasuhiro ^b   Deguchi, Yoshiharu ^c   Kano, Yoshihiro ^a  

^a HOKKAIDO INSTITUTE OF TECHNOLOGY   (Japan)

^b Iskura Industry Co Ltd   (Japan)

^c TEIKYO UNIVERSITY   (Japan)

Author keywords

Drug interaction; Guan xin No. 2; Salvia miltiorrhiza; Thrombosis; Ticlopidine hydrochloride

Indexed keywords

ADENOSINE DIPHOSPHATE; ANTICOAGULANT AGENT; HERBACEOUS AGENT; IMIPRAMINE; KANGEN KARYU; TICLOPIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLEEDING TIME; CHINESE MEDICINE; CONTROLLED STUDY; DRUG BLOOD LEVEL; HEMOSTASIS; HERBAL MEDICINE; HUMAN; MALE; NONHUMAN; RAT; SIDE EFFECT; STATISTICAL SIGNIFICANCE; TAIL; THROMBOCYTE AGGREGATION; THROMBOSIS; THROMBOTIC THROMBOCYTOPENIC PURPURA;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUGS, CHINESE HERBAL; INFUSIONS, INTRAVENOUS; MALE; MEDICINE, CHINESE TRADITIONAL; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RATS; RATS, WISTAR; THROMBOCYTOPENIA; TICLOPIDINE;

CARTHAMUS TINCTORIUS; CNIDIUM; CYPERUS; PAEONIA; PURPURA; SALVIA; SALVIA MILTIORRHIZA; SAUSSUREA;

EID: 0242363166     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1286     Document Type: Article

References (19)

1. Astin J. 1998. Why patients use alternative medicine? Results of a national survey. J Am Med Assoc 279: 1548-1553.
2. Chan K, Lo A, Yeung J, Woo K. 1995. The effect of Danshen (Salvia miltiorrhiza) on warfarin pharmacodynamics and pharmacokinetics of warfarin enantiomers in rats. J Pharm Pharmacol 47: 402-406.
3. Chan TY. 2001. Interaction between warfarin and danshen (Salvia miltiorrhiza). Ann Pharmacother 35: 501-504.
4. Cupp MJ. 1999. Herbal remedies: adverse effects and drug interactions. Am Fam Physician 59: 1239-1245.
5. Gao M, Ikeda K, Noguchi T, Mori K, Yamori Y. 2001. Studies on preventive effect of 'Kangenkaryu', Chinese herbal medicine, on stroke in SHR-SP. J Trad Med 18: 245-250.
6. Gent M, Blakely JA, Easton JD et al. 1989. The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. Lancet 349: 1215-1220.
7. Hass WK, Easton JD, Adams HJ et al. 1989. A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. N Engl J Med 321: 501-507.
8. 3. Prostaglandins 21: 727-738.
9. Lo A, Chan K, Yeung J, Woo K. 1992. The effects of Danshen (Salvia miltiorrhiza) on pharmacokinetics and pharmacodynamics of warfarin in rats. Eur J Drug Metab Pharmacokinet 17: 257-262.
10. Makino T, Wakushima H, Okamoto T, Okukubo Y, Saito K, Kano Y. 2002. Effects of Kangen-Karyu on coagulation system and platelet aggregation in mice. Biol Pharm Bull 25: 523-525.
11. Reid D. 1987. Chinese Herbal Medicine. CFW Publications: Hong Kong.
12. Tabata K, Yamaoka K, Kaibara A, Suzuki S, Terakawa M, Hata T. 1999. Moment analysis program available on Microsoft Excel®. Xenobio Metabol Dispos 14: 286-293.
13. Takahashi M, Sugaya K, Kubota K. 1992. Kangenkaryu prevents the decrease of cholinergic markers following the nucleus basalis magnocellularis lesion. Jpn J Pharmacol 60: 307-310.
14. Tanaka N. 1993. Clinical application of Kangenkaryu-including comparison with Western medicine. Clin Pharm Ther 3: 667-685.
15. The Society of Japanese Pharmacopoeia. 2001. The Japanese Pharmacopoeia 14th edn. Yakuji Nippo: Tokyo.
16. Xu LN, Yin ZZ, Ou YR. 1979. The effect of composite Guan-Xin No.2 on myocardial ischemia and hypoxia in experimental animals. Yao Xue Xue Bao 14: 461-466.
17. Yamaoka K, Nakagawa T, Uno T. 1978. Statistical moments in pharmacokinetics. J Pharmacokinet Biopharm 6: 547-558.
18. Yamaoka K, Tanigawara Y, Nakagawa T, Uno T. 1981. A pharmacokinetic analysis program (multi) for microcomputer. J Pharmacobiodyn 4: 879-885.
19. Zhao J, Li X. 1998. Patterns and Practice in Chinese Medicine. Eastland Press: Seattle.