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Volumn 530, Issue , 2003, Pages 287-296

The Dose-Dependent Effect of RSR13, a Synthetic Allosteric Modifier of Hemoglobin, on Physiological Parameters and Brain Tissue Oxygenation in Rats

Author keywords

Allosteric modifier; Cerebral pO2; EPR oximetry; RSR13

Indexed keywords

BIOLOGICAL RESPONSE MODIFIER; EFAPROXIRAL; HEMOGLOBIN;

EID: 0242362072     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-0075-9_27     Document Type: Conference Paper
Times cited : (16)

References (13)
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    • Allosteric modifiers of hemoglobin. 1. Design, synthesis, testing, and structure-allosteric activity relationship of novel hemoglobin oxygen affinity decreasing agents
    • Randad RS, Mahran MA, Mehanna AS, and Abraham DJ.Allosteric modifiers of hemoglobin. 1. Design, synthesis, testing, and structure-allosteric activity relationship of novel hemoglobin oxygen affinity decreasing agents. J Med Chem 1991;34:752-757
    • (1991) J Med Chem , vol.34 , pp. 752-757
    • Randad, R.S.1    Mahran, M.A.2    Mehanna, A.S.3    Abraham, D.J.4
  • 2
    • 0026080846 scopus 로고
    • Allosteric modifiers of hemoglobin. 2. Crystallographically determined binding sites and hydrophobic binding/interaction. Analysis of novel hemoglobin oxygen effectors
    • Wireko FC, Glen E, Kellogg GE, and Abraham DJ. Allosteric modifiers of hemoglobin. 2. Crystallographically determined binding sites and hydrophobic binding/interaction. Analysis of novel hemoglobin oxygen effectors. J Med Chem 1991;34:758-767.
    • (1991) J Med Chem , vol.34 , pp. 758-767
    • Wireko, F.C.1    Glen, E.2    Kellogg, G.E.3    Abraham, D.J.4
  • 3
    • 0026785750 scopus 로고
    • Allosteric modifiers of hemoglobin: 2-[4-[[(3,5-Disubstituted anilino) carbonyl]methyl]phenoxy]-2-methylpropionic acid derivatives that lower the oxygen affinity of hemoglobin in red cell suspensions, in whole blood, and in vivo in rats
    • Abraham DJ, Wireko FC, and Randad RS. Allosteric modifiers of hemoglobin: 2-[4-[[(3,5-Disubstituted anilino) carbonyl]methyl]phenoxy]-2-methylpropionic acid derivatives that lower the oxygen affinity of hemoglobin in red cell suspensions, in whole blood, and in vivo in rats Biochemistry 1992;31:9141-9149.
    • (1992) Biochemistry , vol.31 , pp. 9141-9149
    • Abraham, D.J.1    Wireko, F.C.2    Randad, R.S.3
  • 4
    • 0029756497 scopus 로고    scopus 로고
    • RSR-13, an allosteric effector of hemoglobin, increases systemic and iliac vascular resistance in rats
    • Kunert MP, Liard JF, and Abraham DJ. RSR-13, an allosteric effector of hemoglobin, increases systemic and iliac vascular resistance in rats. Am J Physiol 1996;271:H602-613.
    • (1996) Am J Physiol , vol.271
    • Kunert, M.P.1    Liard, J.F.2    Abraham, D.J.3
  • 6
    • 0029770717 scopus 로고    scopus 로고
    • RSR: Effects on tumor oxygenation and response to therapy
    • Teicher BA, Ara G, Emi Y, et al. RSR:effects on tumor oxygenation and response to therapy. Drug Dev Res 1996;38:1-11.
    • (1996) Drug Dev Res , vol.38 , pp. 1-11
    • Teicher, B.A.1    Ara, G.2    Emi, Y.3
  • 8
    • 0031891679 scopus 로고    scopus 로고
    • Right-shifting the oxyhemoglobin dissociation curve with rsr13: Effects on high-energy phosphates and myocardial recovery after low-flow ischemia
    • Jason A. Woods, Charles J. Storey, Evelyn E. Babcock and Craig R. Malloy.Right-shifting the oxyhemoglobin dissociation curve with rsr13:effects on high-energy phosphates and myocardial recovery after low-flow ischemia J Cardiovascular Pharmacology 1998;31:359-364.
    • (1998) J Cardiovascular Pharmacology , vol.31 , pp. 359-364
    • Woods, J.A.1    Storey, C.J.2    Babcock, E.E.3    Malloy, C.R.4
  • 9
    • 0027376964 scopus 로고
    • Effect of local change in O2 saturation of hemoglobin on cerebral vasodilution from hypoxia and hypotension
    • Wei EP, Randad RS, Levasseur JE, Abraham DJ, and Kontos HA. Effect of local change in O2 saturation of hemoglobin on cerebral vasodilution from hypoxia and hypotension. Am J Physiol 1993;265:H1439-H1443.
    • (1993) Am J Physiol , vol.265
    • Wei, E.P.1    Randad, R.S.2    Levasseur, J.E.3    Abraham, D.J.4    Kontos, H.A.5
  • 10
    • 0031880194 scopus 로고    scopus 로고
    • Effects of a synthetic allosteric modifier of hemoglobin oxygen affinity on outcome from global cerebral ischemia in the rat
    • Grocott HP, Bart RD, Sheng H, Miura Y, Steffen R, Pearlstein RD, and Warner DC. Effects of a synthetic allosteric modifier of hemoglobin oxygen affinity on outcome from global cerebral ischemia in the rat Stroke. 1998;29:1650-1655.
    • (1998) Stroke , vol.29 , pp. 1650-1655
    • Grocott, H.P.1    Bart, R.D.2    Sheng, H.3    Miura, Y.4    Steffen, R.5    Pearlstein, R.D.6    Warner, D.C.7
  • 12
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    • The measurement of oxygen in vivo using EPR techniques
    • Swartz HM and Clarkson RB. The measurement of oxygen in vivo using EPR techniques. Phys Med Biol 1998;43:1957-1975.
    • (1998) Phys Med Biol , vol.43 , pp. 1957-1975
    • Swartz, H.M.1    Clarkson, R.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.