메뉴 건너뛰기




Volumn 60, Issue 10, 2003, Pages 782-787

Update on the immunosenescence: Humoral and cell-mediated immunity

Author keywords

Elderly; Humoral and cell mediated immunity; Immunosenescence

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERLEUKIN 12; INTERLEUKIN 2; RECOMBINANT GAMMA INTERFERON;

EID: 0242362062     PISSN: 00347264     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (2)

References (49)
  • 1
    • 0024325071 scopus 로고
    • The cellular and subcellular basis of Immunosenescence
    • Thoman ML, Weigle WO: The cellular and subcellular basis of Immunosenescence. Adv Immunol 1989; 46:221.
    • (1989) Adv Immunol , vol.46 , pp. 221
    • Thoman, M.L.1    Weigle, W.O.2
  • 2
    • 0022931316 scopus 로고
    • Population dynamics of bone marrow B-lymphocytes
    • Osmond DG: Population dynamics of bone marrow B-lymphocytes. Immunol Rev 1986; 93:103.
    • (1986) Immunol Rev , vol.93 , pp. 103
    • Osmond, D.G.1
  • 3
    • 0022544546 scopus 로고
    • Immunodeficiency of aging: Restorative effects of phorbol myristate combined with calcium ionophore
    • Miller RA: Immunodeficiency of aging: Restorative effects of phorbol myristate combined with calcium ionophore. J Immunol 1986; 137:805.
    • (1986) J Immunol , vol.137 , pp. 805
    • Miller, R.A.1
  • 4
    • 0018630689 scopus 로고
    • Fractionation, morphological and functional characterization of effector cells responsible for human natural killer activity against cell line targets
    • Timonen T, Saksela E, Ranki, Et al: Fractionation, morphological and functional characterization of effector cells responsible for human natural killer activity against cell line targets. Cell Immunol 1979; 48:133.
    • (1979) Cell Immunol , vol.48 , pp. 133
    • Timonen, T.1    Saksela, E.2    Ranki3
  • 5
    • 0242273034 scopus 로고
    • Immunodeficiency in old age
    • Chandra RK (ed). Edinburgh, Churchill Livingstone
    • Kay MMB: Immunodeficiency in old age. In Chandra RK (ed): Primary and Secondary Immunodeficiency Disorders. Edinburgh, Churchill Livingstone, 1983; p 165.
    • (1983) Primary and Secondary Immunodeficiency Disorders , pp. 165
    • Kay, M.M.B.1
  • 6
    • 0015993711 scopus 로고
    • Impaired lymphocyte function in aged humans
    • Weksler ME, Huterreroth TH: Impaired lymphocyte function in aged humans. J Clin Invest 1974; 53:99.
    • (1974) J Clin Invest , vol.53 , pp. 99
    • Weksler, M.E.1    Huterreroth, T.H.2
  • 7
    • 0017229474 scopus 로고
    • In vitro immune response to 2,4,6, trinitrophenol determinant in aged C57BL/6J mice: Changes in the humoral response to and avidity for the TNP determinant and responsiveness to LPS effect with aging
    • Kishimoto S, Takahama T, Mizumachi H: In vitro immune response to 2,4,6, trinitrophenol determinant in aged C57BL/6J mice: Changes in the humoral response to and avidity for the TNP determinant and responsiveness to LPS effect with aging. J Immunol 1976; 116:294.
    • (1976) J Immunol , vol.116 , pp. 294
    • Kishimoto, S.1    Takahama, T.2    Mizumachi, H.3
  • 8
    • 0017059372 scopus 로고
    • Autoimmunity and aging: The age-related response of mice of a long-lived strain to trinitrophenylated syngeneic mouse red blood cells
    • Naor D, Bonavida B, Walford RL: Autoimmunity and aging: The age-related response of mice of a long-lived strain to trinitrophenylated syngeneic mouse red blood cells. J Immunol 1976; 117:2204.
    • (1976) J Immunol , vol.117 , pp. 2204
    • Naor, D.1    Bonavida, B.2    Walford, R.L.3
  • 9
    • 0014790429 scopus 로고
    • A population study on serum immunoglobulin levels
    • Kallif MW: A population study on serum immunoglobulin levels. Clin Chim Acta 1970; 28:277.
    • (1970) Clin Chim Acta , vol.28 , pp. 277
    • Kallif, M.W.1
  • 10
    • 0022556204 scopus 로고
    • Post-thymic T-cell development
    • Stutman O: Post-thymic T-cell development. Immunol Rev 1986; 91:159.
    • (1986) Immunol Rev , vol.91 , pp. 159
    • Stutman, O.1
  • 11
    • 0018166880 scopus 로고
    • Immunological studies of aging. V. The contribution of thymic involution to the immune deficiencies of aging mice and reversal with thymopoietin
    • Weksler ME, Innes JB, Goldstein G: Immunological studies of aging. V. The contribution of thymic involution to the immune deficiencies of aging mice and reversal with thymopoietin. J Exp Med 1978; 148:996.
    • (1978) J Exp Med , vol.148 , pp. 996
    • Weksler, M.E.1    Innes, J.B.2    Goldstein, G.3
  • 12
    • 0018833714 scopus 로고
    • Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice
    • Scollay RG, Butcher EC, Weissman IL: Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice. Eur J Immunol 1980; 10:210.
    • (1980) Eur J Immunol , vol.10 , pp. 210
    • Scollay, R.G.1    Butcher, E.C.2    Weissman, I.L.3
  • 13
    • 0018881864 scopus 로고
    • Age influence on the immune system
    • Makinodan T, Kay MMB: Age influence on the immune system. Adv Immunol 1980; 29:287.
    • (1980) Adv Immunol , vol.29 , pp. 287
    • Makinodan, T.1    Kay, M.M.B.2
  • 14
    • 0023200924 scopus 로고
    • Age-related defect in signal transduction during lectin activation of murine T Lymphocytes
    • Proust JJ, Filburn CR, Harrison SA, et al: Age-related defect in signal transduction during lectin activation of murine T Lymphocytes. J Immunol 1987; 139:1472.
    • (1987) J Immunol , vol.139 , pp. 1472
    • Proust, J.J.1    Filburn, C.R.2    Harrison, S.A.3
  • 15
    • 0024511525 scopus 로고
    • Stimulation of murine T cells subsets with anti-CD3 antibody. Age-related defects in the expression of early activation molecules
    • Ernst DN, Weigle WO, McQuitty DN et al: Stimulation of murine T cells subsets with anti-CD3 antibody. Age-related defects in the expression of early activation molecules. J Immunol 1989; 142:1413.
    • (1989) J Immunol , vol.142 , pp. 1413
    • Ernst, D.N.1    Weigle, W.O.2    McQuitty, D.N.3
  • 16
    • 0242336347 scopus 로고
    • Subsets of CD4 T cells and B cells activation
    • Bottomly K: Subsets of CD4 T cells and B cells activation. Semin Immunol 1:21.1989
    • (1989) Semin Immunol , vol.1 , pp. 21
    • Bottomly, K.1
  • 17
    • 0021365948 scopus 로고
    • Age-associated decline in precursor frequency for different cell-mediated reactions with preservation of helper or cytotoxic effect per precursor cell
    • Miller RA: Age-associated decline in precursor frequency for different cell-mediated reactions with preservation of helper or cytotoxic effect per precursor cell. J Immunol 1984; 132:63.
    • (1984) J Immunol , vol.132 , pp. 63
    • Miller, R.A.1
  • 18
    • 0023925541 scopus 로고
    • Partial restoration of Con A -induced proliferation, IL-2 receptor expression, and IL-2 synthesis in aged murine lymphocytes by phorbol myristate acetate and ionomycin
    • Thoman ML, Weigle WO: Partial restoration of Con A -induced proliferation, IL-2 receptor expression, and IL-2 synthesis in aged murine lymphocytes by phorbol myristate acetate and ionomycin. Cell Immunol 1988; 114:1.
    • (1988) Cell Immunol , vol.114 , pp. 1
    • Thoman, M.L.1    Weigle, W.O.2
  • 19
    • 0022642871 scopus 로고
    • Decline in age in the proportion of mouse T cells that express IL-2 receptors after mitogen stimulation
    • Vie H, Miller RA: Decline in age in the proportion of mouse T cells that express IL-2 receptors after mitogen stimulation. Mech Ageing Dev 1986; 33:313.
    • (1986) Mech Ageing Dev , vol.33 , pp. 313
    • Vie, H.1    Miller, R.A.2
  • 20
    • 0025736227 scopus 로고
    • Impaired responsiveness of IL-2 receptor-expressing T lymphocytes from aged mice
    • Thoman ML: Impaired responsiveness of IL-2 receptor-expressing T lymphocytes from aged mice. Cell Immunol 1991; 135:410.
    • (1991) Cell Immunol , vol.135 , pp. 410
    • Thoman, M.L.1
  • 21
    • 0026086717 scopus 로고
    • Age-related changes in the activation requirements of human CD4 T-cell subsets
    • Beckman I, Dimopoulos K, Xu X et al: Age-related changes in the activation requirements of human CD4 T-cell subsets. Cell Immunol 1991; 132:17.
    • (1991) Cell Immunol , vol.132 , pp. 17
    • Beckman, I.1    Dimopoulos, K.2    Xu, X.3
  • 22
    • 0000474770 scopus 로고
    • Prevention and reversal of some age-asociated changes in immunologic responses by supplemental dehydroepiandrosterone sulfate therapy
    • Daynes RA, Araneo BA: Prevention and reversal of some age-asociated changes in immunologic responses by supplemental dehydroepiandrosterone sulfate therapy. Aging: Immunology and Infectious Disease 1992; 3:135.
    • (1992) Aging: Immunology and Infectious Disease , vol.3 , pp. 135
    • Daynes, R.A.1    Araneo, B.A.2
  • 23
    • 0025284590 scopus 로고
    • Regulation of murine lymphokine production in vivo. II. Dehydroepiansterone is a natural enhancer of interleukin 2 synthesis by helper T cells
    • Daynes RA, Dudley DJ, Araneo BA: Regulation of murine lymphokine production in vivo. II. Dehydroepiansterone is a natural enhancer of interleukin 2 synthesis by helper T cells. Eur J Immunol 1990; 20:793.
    • (1990) Eur J Immunol , vol.20 , pp. 793
    • Daynes, R.A.1    Dudley, D.J.2    Araneo, B.A.3
  • 24
    • 0025087733 scopus 로고
    • Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion of splenic CD4 T cells from young and aged mice
    • Ernst DN, Hobbs MV, Torbett BE, et al: Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion of splenic CD4 T cells from young and aged mice. J Immunol 1990; 145:1295.
    • (1990) J Immunol , vol.145 , pp. 1295
    • Ernst, D.N.1    Hobbs, M.V.2    Torbett, B.E.3
  • 25
    • 0242367849 scopus 로고
    • Age-related changes in human lymphocyte subsets: Progressive reduction of the CD4 CD45R (suppressor inducer) population
    • DePaoli P, Battisstin S, Santini GF: Age-related changes in human lymphocyte subsets: Progressive reduction of the CD4 CD45R (suppressor inducer) population. Clin Immunol Immunopathol 1988; 19:977.
    • (1988) Clin Immunol Immunopathol , vol.19 , pp. 977
    • DePaoli, P.1    Battisstin, S.2    Santini, G.F.3
  • 26
    • 0023876877 scopus 로고
    • Loss of CD45 (Lp220) represents a post-thymic T cell differentiation event
    • Serra HM, Krowka JF, Ledbetter JA et al: Loss of CD45 (Lp220) represents a post-thymic T cell differentiation event. J Immunol 1988; 140:1435.
    • (1988) J Immunol , vol.140 , pp. 1435
    • Serra, H.M.1    Krowka, J.F.2    Ledbetter, J.A.3
  • 28
    • 0025979518 scopus 로고
    • Antigen presentation: Structural themes and functional variations
    • Braciale T, Braciale V: Antigen presentation: Structural themes and functional variations. Immunol Today 1991; 12:124.
    • (1991) Immunol Today , vol.12 , pp. 124
    • Braciale, T.1    Braciale, V.2
  • 29
    • 0026680874 scopus 로고
    • Apoptosis and programmed cell death in immunity
    • Cohen J: Apoptosis and programmed cell death in immunity. Annu Rev Immunol 1992; 10:267.
    • (1992) Annu Rev Immunol , vol.10 , pp. 267
    • Cohen, J.1
  • 30
    • 0002920627 scopus 로고
    • Apoptosis in cell-mediated immunity
    • Cold Spring Harbor, NY, Cold Spring Harbor Laboaratory Press
    • Duke R: Apoptosis in cell-mediated immunity. In: Apoptosis: The Molecular Basis of cell death. Cold Spring Harbor, NY, Cold Spring Harbor Laboaratory Press, 1991, p 209.
    • (1991) Apoptosis: The Molecular Basis of Cell Death , pp. 209
    • Duke, R.1
  • 31
    • 0019507223 scopus 로고
    • A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1)
    • Abo T, Balch C: A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1). J Immunol 1981; 127:1024.
    • (1981) J Immunol , vol.127 , pp. 1024
    • Abo, T.1    Balch, C.2
  • 32
    • 0242336349 scopus 로고
    • Low natural killer (NK) cell activity in the peripheral blood of metastasis-free cancer patients is associated with reduced metastasis-free survival time
    • Alberta, Canada
    • th International Leukocyte Conference, Alberta, Canada, 1988.
    • (1988) th International Leukocyte Conference
    • Pross, H.F.1    Baines, M.G.2
  • 33
    • 0022907923 scopus 로고
    • Subpopulation analysis of human granular lymphocytes: Association with age, gender and cytotoxic activity
    • Tilden AB, Grossi CE, Itoh K, et al: Subpopulation analysis of human granular lymphocytes: Association with age, gender and cytotoxic activity. Nat Immun Cell Growth Reg 1986; 5:90.
    • (1986) Nat Immun Cell Growth Reg , vol.5 , pp. 90
    • Tilden, A.B.1    Grossi, C.E.2    Itoh, K.3
  • 34
    • 84909659822 scopus 로고
    • Quantitative and qualitative differences in natural killer cell activity in aging
    • Krishnaraj R, Blandford G: Quantitative and qualitative differences in natural killer cell activity in aging (abstract). Gerontologist 1984; 24:113.
    • (1984) Gerontologist , vol.24 , pp. 113
    • Krishnaraj, R.1    Blandford, G.2
  • 35
    • 0023918758 scopus 로고
    • Age-associated alterations in human natural killer cells
    • Krishnaraj R, Blandford G: Age-associated alterations in human natural killer cells. Cell Immunol 1988; 114:137.
    • (1988) Cell Immunol , vol.114 , pp. 137
    • Krishnaraj, R.1    Blandford, G.2
  • 36
    • 0021955187 scopus 로고
    • Subpopulation of mononuclear cells in aging; expansion of the null cell compartment and decrease in the number of T and B cells in human blood
    • Ligthart GL, Schuit HRE, Hijmans W: Subpopulation of mononuclear cells in aging; expansion of the null cell compartment and decrease in the number of T and B cells in human blood. Immunology 1985; 55:15.
    • (1985) Immunology , vol.55 , pp. 15
    • Ligthart, G.L.1    Schuit, H.R.E.2    Hijmans, W.3
  • 37
    • 0023225697 scopus 로고
    • Increased number of circulating Leu 11+(CD16) large granular lymphocytes and decreased NK activity during human aging
    • Facchini A, Mariani E, Mariana AR, et al: Increased number of circulating Leu 11+(CD16) large granular lymphocytes and decreased NK activity during human aging. Clin Exp Immunol 1987; 68:340.
    • (1987) Clin Exp Immunol , vol.68 , pp. 340
    • Facchini, A.1    Mariani, E.2    Mariana, A.R.3
  • 38
    • 0002466735 scopus 로고
    • Age and sex-related changes of the lymphocyte subsets in healthy individuals: An analysis by two-dimensional flow cytometry
    • Goto M, Nishioka KI: Age and sex-related changes of the lymphocyte subsets in healthy individuals: An analysis by two-dimensional flow cytometry. J Gerontol 1989; 44:M51.
    • (1989) J Gerontol , vol.44
    • Goto, M.1    Nishioka, K.I.2
  • 39
    • 0020041222 scopus 로고
    • Postnatal expansion of the natural killer and killer cell population in humans identified by the monoclonal HNK-1 antibody
    • Abo T, Cooper M, Balch CM: Postnatal expansion of the natural killer and killer cell population in humans identified by the monoclonal HNK-1 antibody. J Exp Med 1982; 155:321.
    • (1982) J Exp Med , vol.155 , pp. 321
    • Abo, T.1    Cooper, M.2    Balch, C.M.3
  • 41
    • 0021919453 scopus 로고
    • Direct evidence for the role of LGL in the inhibition of experimental tumor metastases
    • Barlozzari T, Leonhardt J, Wiltrout R, et al: Direct evidence for the role of LGL in the inhibition of experimental tumor metastases. J Immunol 1985; 134:2783.
    • (1985) J Immunol , vol.134 , pp. 2783
    • Barlozzari, T.1    Leonhardt, J.2    Wiltrout, R.3
  • 42
    • 0019426169 scopus 로고
    • Increased killer cell activity in aged humans
    • Batory G, Benczur M, Varga M, et al: Increased killer cell activity in aged humans. Immunobiology 1981; 158:393.
    • (1981) Immunobiology , vol.158 , pp. 393
    • Batory, G.1    Benczur, M.2    Varga, M.3
  • 43
    • 0019592559 scopus 로고
    • Natural killing and antibody-dependent cytotoxicity by lymphocyte subpopulations in young and aging humans
    • Fernandes G, Gupta S: Natural killing and antibody-dependent cytotoxicity by lymphocyte subpopulations in young and aging humans. J Clin Immunol 1981; 1(3):141.
    • (1981) J Clin Immunol , vol.1 , Issue.3 , pp. 141
    • Fernandes, G.1    Gupta, S.2
  • 44
    • 0023205403 scopus 로고
    • Age-associated alterations in human natural killer cells
    • Krishnaraj R: Age-associated alterations in human natural killer cells. Clin Immunol Immunopathol 1987; 45:268.
    • (1987) Clin Immunol Immunopathol , vol.45 , pp. 268
    • Krishnaraj, R.1
  • 45
    • 0026677147 scopus 로고
    • Preferential accumulation of mature NK cells during human Immunosenescence
    • Krishnaraj R: Preferential accumulation of mature NK cells during human Immunosenescence. J Cell Biochem 1982; 50:386.
    • (1982) J Cell Biochem , vol.50 , pp. 386
    • Krishnaraj, R.1
  • 46
    • 0024374054 scopus 로고
    • Natural killer cell function is not diminished in healthy aged and is proportional to the number of NK cells in the peripheral blood
    • Ligthart GL, Schuit HRE, Hijmans W: Natural killer cell function is not diminished in healthy aged and is proportional to the number of NK cells in the peripheral blood. Immunology 1992; 68:396.
    • (1992) Immunology , vol.68 , pp. 396
    • Ligthart, G.L.1    Schuit, H.R.E.2    Hijmans, W.3
  • 47
    • 0019429964 scopus 로고
    • Spontaneous or natural killer cytotoxicity of K562 erythrleukemic cells in normal patients
    • Nagel JE, Collins GD, Alder WA: Spontaneous or natural killer cytotoxicity of K562 erythrleukemic cells in normal patients. Cancer Res 1981; 41:2284.
    • (1981) Cancer Res , vol.41 , pp. 2284
    • Nagel, J.E.1    Collins, G.D.2    Alder, W.A.3
  • 48
    • 0027231011 scopus 로고
    • MHC Class I expression on tumor targets inhibits natural killer cell-mediated cytotoxicity without interfering with target recognition
    • Kaufman D, Schoon R, Leibson P: MHC Class I expression on tumor targets inhibits natural killer cell-mediated cytotoxicity without interfering with target recognition. J Immunol 1993; 150:1429.
    • (1993) J Immunol , vol.150 , pp. 1429
    • Kaufman, D.1    Schoon, R.2    Leibson, P.3
  • 49
    • 0017108720 scopus 로고
    • Immunology of aging: Evaluation of current status
    • Kay MB, Makinodan I: Immunology of aging: Evaluation of current status. Clin Immunol Immunopathol 1976; 6:394.
    • (1976) Clin Immunol Immunopathol , vol.6 , pp. 394
    • Kay, M.B.1    Makinodan, I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.