Development of a method for the direct analysis of peptide AM336 in monkey cerebrospinal fluid using liquid chromatography/electrospray ionization mass spectrometry with a mixed-function column

Rapid Communications in Mass Spectrometry

Volumn 17, Issue 21, 2003, Pages 2394-2398

  Bu, Wei ^a   Freer, Scott D ^a   Hollar, Shelly M ^a   Stetson, Philip L ^a   Boyd, Robert A ^b   Kurek, John B ^c   Sved, Daniel W ^a  

^a WIL RESEARCH LABORATORIES   (United States)

^b Northern Biomedical Research Inc   (United States)

^c Zenyth Therapeutics Limited Australia   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CALIBRATION; CEREBROSPINAL FLUID; COLUMN CHROMATOGRAPHY; DIRECT INJECTION; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SIGNAL TO NOISE RATIO;

ANALYTICAL PROCEDURE; DIRECT ANALYSIS; GRADIENT ELUTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY COLUMNS; IONIZATION MODES; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; LIQUID CHROMATOGRAPHY-ELECTROSPRAY IONIZATION-MASS SPECTROMETRIES; POSITIVE ELECTROSPRAY IONIZATION; SAMPLE CLEAN-UP; VALVES SWITCHING;

PEPTIDES;

PEPTIDE; PEPTIDE AM336; POLYMER; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ARTICLE; CALIBRATION; CEREBROSPINAL FLUID ANALYSIS; COLUMN CHROMATOGRAPHY; CONCENTRATION (PARAMETERS); CORRELATION COEFFICIENT; DIRECT INJECTION TECHNIQUE; EVALUATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETER; MASS SPECTROMETRY; MONKEY; NONHUMAN; PEPTIDE ANALYSIS; PROTEIN DETERMINATION; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SAMPLE; SEPARATION TECHNIQUE; SIGNAL NOISE RATIO; STANDARD; TECHNIQUE; VALIDATION PROCESS;

EID: 0242354929     PISSN: 09514198     EISSN: None     Source Type: Journal    
DOI: 10.1002/rcm.1209     Document Type: Article

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