Cytotoxic Biotransformed Products from Triptonide by Aspergillus niger

Planta Medica

Volumn 69, Issue 9, 2003, Pages 804-808

  Ning, Lili ^a,b   Qu, Guiqin ^a   Ye, Min ^a   Guo, Hongzhu ^a   Bi, Kaishun ^b   Guo, Dean ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Aspergillus niger; Biotransformation; Cytotoxic activity; Tripterygium wilfordii; Triptonide

Indexed keywords

16 HYDROXYTRIPTONIDE; 17 HYDROXYTRIPTONIDE; 5ALPHA HYDROXYTRIPTONIDE; PACLITAXEL; TRIPTERYGIUM WILFORDII EXTRACT; TRIPTOLIDE; TRIPTONIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ASPERGILLUS NIGER; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG STRUCTURE; DRUG TRANSFORMATION; HELA CELL; HUMAN; HUMAN CELL; IC 50; MEDICINAL PLANT; STRUCTURE ANALYSIS; TRIPTERYGIUM WILFORDII; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; ASPERGILLUS NIGER; BIOTRANSFORMATION; CELL LINE, TUMOR; HUMANS; INHIBITORY CONCENTRATION 50; PHYTOTHERAPY; PLANT EXTRACTS; TRITERPENES;

ASPERGILLUS; ASPERGILLUS NIGER; TRIPTERYGIUM;

EID: 0242351914     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-43220     Document Type: Article

References (11)

1. Matlin SA, Belenguer A, Stacey VE, Qian SZ, Xu Y, Zhang JW et al. Male antifertility compounds from Tripterygium wilfordii Hook. f. Contraception 1993; 47: 387-400
2. Qian SZ, Xu Y, Zhang JW. Recent progress in research on Tripterygium: A male antifertility plant. Contraception 1995; 51: 121-9
3. Wang XW, Xie H. Recent studies on Tripterygium wilfordii. Drugs of the Future 1999; 24: 991-7
4. Yang Y, Liu ZH, Tolosa E, Yang JW, Li LS. Triptolide induces apoptotic death of T lymphocyte. Immunopharmacology 1998; 40: 139-49
5. Chan EWC, Cheng SCS, Sin FWY, Xie Y. Triptolide induced cytotoxic effects on human promyelocytic leukemia, T cell lymphoma and human hepatocellular carcinoma cell lines. Toxicology Letters 2001; 122: 81-7
6. Kupchan SM, Court WA, Dailey RG, Gilmore CJ, Bryan RF. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii. Journal of the American Chemical Society 1972; 94: 7194-5
7. Pei RJ, Qi LH, Liu XJ. Effects of triptonide on mouse immune functions. Acta Pharmacologica Sinica 1993; 14: 238-42
8. Wang L, Ye W, Hui L, Liu X, Guo Y. Male contraception of triptonide and its function mechanisms. Acta Academica Medicinae Sinicae 2000; 22: 223-6
9. Giri A, Dhingra V, Giri CC, Singh A, Ward OP, Narasu ML. Biotransformation using plant cells, organ cultures and enzyme systems: current trends and future prospects. Biotechnology Advances 2001; 19: 175-99
10. Abourashed EA, Clark AM, Hufford CD. Microbial Models of Mammalian Metabolism of Xenobiotics: An Updated Review. Current Medicine Chemistry 1999; 6: 359-74
11. Jezequel SG. Microbial models of mammalian metabolism: uses and misuses (clarification of some misconceptions). Journal of Molecular Catalysis B: Enzymatic 1998; 5: 371-7