Concurrent Lymph Node Metastases of Medullary and Papillary Thyroid Carcinoma in a Case with RET Oncogene Germline Mutation

Endocrine Pathology

Volumn 14, Issue 3, 2003, Pages 269-276

  Papi, G ^c   Corrado, S ^d   Pomponi, M G ^a   Carapezzi, C ^d   Cesinaro, A ^d   LiVolsi, V A ^b  

^a CATHOLIC UNIVERSITY   (Italy)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^c Ospedale Ramazzini   (Italy)

^d NONE

Author keywords

Lymph node; Medullary carcinoma; Papillary carcinoma; Thyroid

Indexed keywords

AGED; ARTICLE; ASPIRATION BIOPSY; CASE REPORT; CERVICAL LYMPH NODE; FEMALE; GENE MUTATION; GERIATRIC PATIENT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; METASTASIS; PRIORITY JOURNAL; PROTO ONCOGENE; THYROID CARCINOMA; THYROID MEDULLARY CARCINOMA; THYROID NODULE; THYROID PAPILLARY CARCINOMA; THYROIDECTOMY;

AGED; CARCINOMA, MEDULLARY; CARCINOMA, PAPILLARY; COMBINED MODALITY THERAPY; GERM-LINE MUTATION; HUMANS; LYMPHATIC METASTASIS; NEOPLASMS, SECOND PRIMARY; ONCOGENE PROTEINS; ONCOGENES; POINT MUTATION; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; THYROID NEOPLASMS; THYROIDECTOMY; TREATMENT OUTCOME;

EID: 0242351686     PISSN: 10463976     EISSN: None     Source Type: Journal    
DOI: 10.1385/EP:14:3:269     Document Type: Article

References (18)

1. Heshmati HM, Gharib H, van Heerden JA, Sizemore GW. Advances and controversies in the diagnosis and management of medullary thyroid carcinoma. Am J Med 103:60-69, 1997.
2. Murray D. The thyroid gland. In: Kovacs K, Asa S, eds. Functional endocrine pathology, vol. 1. Boston: Blackwell, pp. 293-374, 1991.
3. Eng C, Clayton D, Schuffenecker I, et al. The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis. JAMA 276:1575-1579, 1996.
4. Hedinger C, Williams ED, Sobin LH. The WHO histological classification of thyroid tumors: a commentary on the second edition. Cancer 63:908-911, 1989.
5. Lamberg BA, Reissel P, Stenman S, et al. Concurrent medullary and papillary thyroid carcinoma in the same thyroid lobe and in siblings. Acta Med Scand 209:421-424, 1981.
6. Albores-Saavedra J, de la Mora TG, Gould E. Mixed medullary-papillary carcinoma of the thyroid: a previously unrecognized variant of thyroid gland. Hum Pathol 21:1151-1155, 1990.
7. Apel RL, Alpert LC, Rizzo A, LiVolsi V, Asa SL. A metastasizing composite carcinoma of the thyroid with distinct medullary and papillary components. Arch Pathol Lab Med 118:1143-1147, 1994.
8. Matias-Guiu X, Caxas A, Costa I, Cadezas R, Prat J. Compound medullary-papillary carcinoma of the thyroid: true mixed tumour. Histopathology 25:183-185, 1994.
9. Pastolero GC, Coire CI, Asa SL. Concurrent medullary and papillary carcinomas of the thyroid with lymph node metastases. A collision phenomenon. Am J Surg Pathol 20:245-250, 1996.
10. Shimizu M, Hirokawa M, LiVolsi VA, et al. Combined "mixed medullary-follicular" and "papillary" carcinoma of the thyroid with lymph node metastasis. Endocr Pathol 11:353-358, 2000.
11. Shiroko T, Yokoo N, Okamoto K, et al. Mixed medullary-papillary carcinoma of the thyroid with lymph node metastases: report of a case. Surg Today 31:317-321, 2001.
12. Brauckhoff M, Gimm O, Hinze R, Ukkat J, Brauckhoff K, Dralle H. Papillary thyroid carcinoma in patients with RET proto-oncogene germline mutation. Thyroid 12:557-561, 2002.
13. Hales M, Rosenau W, Okerlund MD, Galante M. Carcinoma of the thyroid with a mixed medullary and follicular pattern. Morphologic, immunohistochemical, and clinical laboratory studies. Cancer 50:1352-1359, 1982.
14. Ljungberg O, Ericsson UB, Bodenson L, Thorell J. A compound follicular-parafollicular cell carcinoma of the thyroid: a new tumor entity? Cancer 52:1053-1061, 1983.
15. LiVolsi VA. Mixed thyroid carcinoma: a real entity? Lab Invest 57:237-239, 1987.
16. Volante M, Papotti M, Roth J, et al. Mixed medullary-follicular thyroid carcinoma. Molecular evidence for a dual origin of tumor components. Am J Pathol 155:1499-1509, 1999.
17. Lupoli G, Vitale G, Caraglia M, et al. Familial papillary thyroid microcarcinoma: a new clinical entity. Lancet 353:637-639, 1999.
18. Fugazzola L, Cerutti N, Mannavola D, et al. Multigenerational familial medullary thyroid cancer (FMTC): evidence for FMTC phenocopies and association with papillary thyroid cancer. Clin Endocrinol (Oxf) 56:53-63, 2002.