Synaptic Vesicle Morphology and Recycling Are Altered in Myenteric Neurons of Mice Lacking Dystrophin (mdx Mice)

Journal of Cellular Physiology

Volumn 197, Issue 2, 2003, Pages 232-242

  Vannucchi, Maria Giuliana ^a   Corsani, Letizia ^a   Faussone Pellegrini, Maria Simonetta ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DYSTROPHIN; DYSTROPHIN ISOFORM; UNCLASSIFIED DRUG; ISOPROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CYCLE; CELL STRUCTURE; CELL SUBPOPULATION; CELL ULTRASTRUCTURE; COGNITIVE DEFECT; CONTROLLED STUDY; DIGESTIVE SYSTEM FUNCTION DISORDER; DUCHENNE MUSCULAR DYSTROPHY; ENDOPLASMIC RETICULUM; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL MOTILITY DISORDER; IMMUNOHISTOCHEMISTRY; MOUSE; MOUSE STRAIN; MYENTERIC NEURON; MYENTERIC PLEXUS; MYOPATHY; NERVE CELL; NEUROPATHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE; SMOOTH MUSCLE; SYNAPSE VESICLE; ANIMAL; C57BL MOUSE; COLON; DISEASE MODEL; ELECTRON MICROSCOPY; GASTROINTESTINAL DISEASE; GENETICS; INNERVATION; INTRACELLULAR MEMBRANE; METABOLISM; MOLECULAR WEIGHT; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; PROTEIN TRANSPORT; SYNAPTOSOME; TRANSPORT VESICLE; ULTRASTRUCTURE; X CHROMOSOME LINKED MUSCULAR DYSTROPHIC MOUSE;

ANIMALIA;

ANIMALS; COLON; DISEASE MODELS, ANIMAL; DYSTROPHIN; ENDOPLASMIC RETICULUM; GASTROINTESTINAL DISEASES; GASTROINTESTINAL MOTILITY; IMMUNOHISTOCHEMISTRY; INTRACELLULAR MEMBRANES; MICE; MICE, INBRED C57BL; MICE, INBRED MDX; MICROSCOPY, ELECTRON; MOLECULAR WEIGHT; MUSCULAR DYSTROPHY, DUCHENNE; MUTATION; MYENTERIC PLEXUS; NEURONS; PRESYNAPTIC TERMINALS; PROTEIN ISOFORMS; PROTEIN TRANSPORT; SYNAPTIC VESICLES; TRANSPORT VESICLES;

EID: 0242348822     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.10305     Document Type: Article

References (25)

1. Ahn AH, Kunkel LM. 1994. The structural and functional diversity of dystrophin. Nat Genet 3:283-291.
2. Azzena GB, Mancinelli R. 1999. Nitric oxide regenerates the normal colonic peristaltic activity in mdx dystrophic mouse. Neurosci Lett 261:9-12.
3. Baccari MC, Romagnani P, Calamai F. 2000. Impaired nitrergic relaxations in the gastric fundus of dystrophic (mdx) mice. Neurosci Lett 282:105-108.
4. Barohn RJ, Levine EJ, Olson JO, Mendell JR. 1988. Gastric hypomotility in Duchenne's muscular dystrophy. New Engl J Med 319:15-18.
5. Beck KA, Buchanan JA, Malhotra V, Nelsen WJ. 1995. Golgi spectrin: Identification of an erythroid b-spectrin homolog associated with the Golgi. J Cell Biol 127:707-723.
6. Bensen ES, Jaffe KM, Tarr PI. 1996. Acute gastric dilatation in Duchenne muscular dystrophy: A case report and review of the literature. Arch Phys Med Rehabil 77:512-514.
7. De Stefano ME, Zaccaria ML, Cavaldesi M, Petrucci TC, Medori R, Paggi P. 1997. Dystrophin and its isoforms in a sympathetic ganglion of normal and dystrophic mdx mice: Immunolocalization by electron microscopy and biochemical characterization. Neuroscience 80:613-624.
8. Fabbrizio E, Nudel U, Hugon G, Robert A, Pons F, Mornet D. 1994. Characterization and localization of a 77 kDa protein related to the dystrophin gene family. Biochem J 299:359-365.
9. Furness JB, Costa M. 1987. The enteric nervous system. London: Churchill Livingstone, Inc.
10. Gorecki DC, Barnard EC. 1995. Specific expression of G-dystrophin (Dp71) in the brain. NeuroReport 6:893-896.
11. Jancsik V, Hajos F. 1998. Differential distribution of dystrophin in postsynaptic densities of spine synapses. NeuroReport 9:2249-2251.
12. Jasmin BJ, Cartaud A, Ludosky MA, Changeux JP, Cartaud J. 1990. Asymmetric distribution of dystrophin in developing and adult Torpedo marmorata electrocyte: Evidence for its association with the acetylcholine receptor-rich membrane. Proc Natl Acad Sci USA 87:3938-3941.
13. Knuesel I, Mastrocola M, Zuellig RA, Bornhauser B, Schaub MC, Fritschy JM. 1999. Altered synaptic clustering of GABA-A receptors in mice lacking dystrophin (mdx mice). Eur J Neurosci 11:4457-4462.
14. Lederfein D, Levy Z, Augier N, Mornet D, Fuchs O, Yaffe D, Nudel U. 1992. A 71 kDa protein is a major product of the Duchenne muscular dystrophy gene in brain and other non muscle tissue. Proc Natl Acad Sci USA 89:5346-5350.
15. Lidov HGW. 1996. Dystrophin in the nervous system. Brain Pathol 6:63-77.
16. Lidov HGW, Byers TJ, Kunkel LM. 1993. The distribution of dystrophin in the murine central nervous system: An immunocytochemical study. Neuroscience 54:167-187.
17. Mancinelli R, Tonali P, Serbidei S, Azzena GB. 1995. Analysis of peristaltic reflex in young dystrophic mouse. Neurosci Lett 192:57-60.
18. Mulè F, D'Angelo G, Tabacchi A, Amato A, Serio R. 1999. Mechanical activity of small and large intestine in normal and mdx mice: A comparative analysis. Neurogastroenterol Motil 11:133-139.
19. Rivier F, Robert A, Latouche J, Hugon G, Mornet D. 1997. Expression of a new mr 70 kDa dystrophin-related protein in the axon of peripheral nerves from Torpedo marmorata. Comp Biochem Physiol 116B:19-26.
20. Serio R, Bonvissuto F, Mulè F. 2001. Altered electrical activity in colonic smooth muscle cells from dystrophic (mdx) mice. Neurogastroenterol Motil 13:169-175.
21. Uchino M, Teramoto H, Naoe H, Yoshioka K, Miike T, Ando M. 1994. Localisation and characterisation of dystrophin in the central nervous system of controls and patients with Duchenne muscular dystrophy. J Neurol Neurosurg Psych 57:426-429.
22. Vannucchi MG, Corsani L, Giovannini MG, Faussone-Pellegrini MS. 2001. Expression of dystrophin in the mouse myenteric neurons. Neurosci Lett 300:120-124.
23. Wiedenmann B, Franke WW. 1985. Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of pre-synaptic vesicles. Cell 41:1017-1028.
24. Yoshida MM, Krishnamurthy S, Wattchow DA, Furness JB, Schuffier MD. 1988. Megacolon in myotonic dystrophy caused by a degenerative neuropathy of the myenteric plexus. Gastroenterology 95:820-827.
25. Zaccaria ML, De Stefano ME, Gotti C, Petrucci TC, Paggi P. 2000. Selective reduction in the nicotinic acetylcholine receptor and dystroglycan at the postynaptic apparatus of mdx mouse superior cervical ganglion. J Neuropath Exp Neurol 59:103-112.