Pharmacokinetics of (-)-epicatechin-3-O-gallate, an active component of Onpi-to, in rats

Biological and Pharmaceutical Bulletin

Volumn 26, Issue 5, 2003, Pages 608-612

  Takizawa, Yukiho ^a   Morota, Takashi ^a   Takeda, Shuichi ^a   Aburada, Masaki ^a  

^a TSUMURA AND CO   (Japan)

Author keywords

( ) epicatechin 3 O gallate (ECG); HPLC electrochemical detection (ECD); Pharmacokinetic, rat; Plasma; Urine

Indexed keywords

DELTA (3 METHOXY 4 HYDROXYPHENYL) GAMMA VALEROLACTONE; DELTA (3,4 DIHYDROXYPHENYL) GAMMA VALEROLACTONE; DRUG METABOLITE; EPICATECHIN 3 O GALLATE; EPICATECHIN GALLATE; HERBACEOUS AGENT; ONPI TO; UNCLASSIFIED DRUG; CATECHIN; DELTA(3 METHOXY 4 HYDROXYPHENYL) GAMMA VALEROLACTONE; DELTA(3,4 DIHYDROXYPHENYL) GAMMA VALEROLACTONE; DELTA(3,4-DIHYDROXYPHENYL)-GAMMA-VALEROLACTONE; DELTA(3-METHOXY-4-HYDROXYPHENYL)-GAMMA-VALEROLACTONE; DRUG DERIVATIVE; LACTONE; ONPI-TO;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; ELECTROCHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; ANIMAL; BIOAVAILABILITY; BLOOD; CHEMISTRY; HALF LIFE TIME; INTRAVENOUS DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; SPRAGUE DAWLEY RAT; URINE;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CATECHIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; HALF-LIFE; INJECTIONS, INTRAVENOUS; LACTONES; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0242341414     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.26.608     Document Type: Article

References (14)

1. Yokozawa T., Wu X. Q., Lee T. W., Oura H., J. Med. Pharm. Soc., 5, 179-183 (1988).
2. Mitsuma T., Yokozawa T., Oura H., Terasawa K , Jpn. J. Nephrol , 29, 195-207 (1987).
3. Yokozawa T., Fujioka K., Oura H., Nonaka G., Nishioka I , Nephron, 58, 155-160 (1991).
4. Yokozawa T., Fujioka K., Oura H., Nonaka G., Nishioka I., Jpn. J. Nephrol., 35, 13-18 (1993).
5. Fujitsuka N., Kurogi A., Hattori T., Shindo S., Jpn. J Nephrol , 39, 693-700 (1997).
6. Awata N., Miura S., Hamada T., Satomi O., Midorikawa T., Pharmacometrics, 25, 993-1006 (1983).
7. Miura S., Hamada T., Satomi O. Midorikawa T., Awata N., Pharmacometrics, 25, 1015-1024 (1983).
8. Okushio K., Matsumoto N., Kohri T., Suzuki M., Biol Pharm Bull., 19, 326-329 (1996).
9. Chen L., Lee M.-J., Li H , Yang C. S., Drug Metab. Dispos., 25, 1045-1050 (1997).
10. Griffiths L. A., Biochem. J , 92, 173-179 (1964).
11. Das N. P., Griffiths L. A., Biochem J , 115, 831-836 (1969)
12. Shaw I. C., Griffiths L. A., Xenobiotica, 10, 905-911 (1980).
13. Hackett A. M., Shaw I. C., Griffiths L A., Experientia, 38, 538-540 (1982).
14. Meselhy M. R., Nakamura N., Hattori M., Chem. Pharm. Bull., 45, 888-893 (1997).