Nitrate Tolerance in Hypertension: New Insight Into a Century-Old Problem

Circulation Research

Volumn 93, Issue 9, 2003, Pages 799-801

  Knot, Harm J ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

Ca2+ sparks; Ca2+ activated potassium channel; Nitrates

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; GLYCERYL TRINITRATE; ISOSORBIDE MONONITRATE; NITRATE; NITRIC OXIDE; ORGANIC NITRATE;

ANGINA PECTORIS; DRUG MECHANISM; EDITORIAL; HEART FAILURE; HYPERTENSION; ISCHEMIC HEART DISEASE; PRIORITY JOURNAL; THORAX PAIN; VASODILATATION;

ANIMALS; BLOOD VESSELS; CALCIUM SIGNALING; DRUG TOLERANCE; HUMANS; HYPERTENSION; NITRATES; NITROGLYCERIN; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; SIGNAL TRANSDUCTION; VASODILATION;

EID: 0242330189     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000100846.76792.C2     Document Type: Editorial

References (16)

1. Brunton L. On the use of nitrite amyl in angina pectoris. Lancet. 1867; ii:97-98.
2. Marsh N, Marsh A. A short history of nitroglycerine and nitric oxide in pharmacology and physiology. Clin Exp Pharmacol Physiol. 2000;27:313-319.
3. Horowitz JD. Amelioration of nitrate tolerance: matching strategies with mechanisms. J Am Coll Cardiol. 2003;41:2001-2003.
4. Gori T, Parker JD. Nitrate tolerance: a unifying hypothesis. Circulation. 2002;106:2510-2513.
5. 2+] in cerebral arteries of rat by membrane potential and intravascular pressure. J Physiol. 1998;508(pt 1):199-209.
6. Robertson BE, Schubert R, Hescheler J, Nelson MT. cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells. Am J Physiol. 1993;265:C299-C303.
7. + channel, Hslo, is a target of cGMP-dependent protein kinase phosphorylation in vivo. J Biol Chem. 1998;273:32950-32956.
8. Brayden JE, Nelson MT. Regulation of arterial tone by activation of calcium-dependent potassium channels. Science. 1992;256:532-535.
9. Nelson MT, Cheng H, Rubart M, Santana LF, Bonev AD, Knot HJ, Lederer WJ. Relaxation of arterial smooth muscle by calcium sparks. Science. 1995;270:633-637.
10. 2+ sparks and spontaneous transient outward currents in single smooth muscle cells. J Gen Physiol. 1999;113:215-228.
11. Meera P, Wallner M, Jiang Z, Toro L. A calcium switch for the functional coupling between α (hslo) and β subunits (Kv,caβ) of maxi K channels. FEBS Lett. 1996;385:127-128.
12. 2+ sparks is involved in regulation of arterial diameter by cyclic nucleotides. Am J Physiol. 1998;274:C1346-C1355.
13. Gerzanich V, Ivanov A, Ivanova S, Yang JB, Zhou H, Dong Y, Simard M. Alternative splicing of cGKI in angiotensin-hypertension: novel mechanism for nitrate tolerance in vascular smooth muscle. Circ Res. 2003;93:805-812.
14. Munzel T, Bassenge E. Long-term angiotensin-converting enzyme inhibition with high-dose enalapril retards nitrate tolerance in large epicardial arteries and prevents rebound coronary vasoconstriction in vivo. Circulation. 1996;93:2052-2058.
15. + channels in vascular smooth muscle during hypertension. J Clin Invest. 2003;112:717-724.
16. + channels in the cerebral microcirculation of genetically hypertensive rats: evidence for their protection against cerebral vasospasm. Circ Res. 1998;82:729-737.