Synthesis and pharmacokinetic profile of a quaternary ammonium derivative of chlorambucil, a potential anticancer drug for the chemotherapy of chondrosarcoma

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 23, 2003, Pages 5007-5012

  Rapp, Maryse ^a   Giraud, Isabelle ^a   Maurizis, Jean Claude ^a   Madelmont, Jean Claude ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BUTYRIC ACID DERIVATIVE; CARBON 14; CHLORAMBUCIL; QUATERNARY AMMONIUM DERIVATIVE; UNCLASSIFIED DRUG; [3 [[4 [4 [BIS(2 CHLOROETHYL)AMINO]PHENYL]BUTANOYL]AMINO]PROPYL]TRIMETHYLAMMONIUM IODIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CHEMOTHERAPY; CARTILAGINOUS TISSUE; CHONDROSARCOMA; CONTROLLED STUDY; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG LABELING; DRUG SELECTIVITY; DRUG SYNTHESIS; FECES ANALYSIS; MALE; NONHUMAN; QUANTITATIVE ANALYSIS; RADIOACTIVITY; RAT; TISSUE DISTRIBUTION; URINALYSIS;

EID: 0242329794     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.09.006     Document Type: Article

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