Cardiovascular, haematological and neurological effects of the venom of the Papua New Guinean small-eyed snake (Micropechis ikaheka) and their neutralisation with CSL polyvalent and black snake antivenoms

Toxicon

Volumn 42, Issue 6, 2003, Pages 647-655

  Tibballs, J ^a,d   Kuruppu, S ^b   Hodgson, W C ^b   Carroll, T ^c   Hawdon, G ^a   Sourial, M ^d   Baker, T ^d   Winkel, K ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c CSL LIMITED   (Australia)

^d ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

Antivenom; Cardiovascular; Micropechis ikaheka; Neurotoxicity; Small eyed snake; Venom

Indexed keywords

CREATINE KINASE; HEMOGLOBIN; POTASSIUM; SERUM ALBUMIN; SNAKE VENOM; SNAKE VENOM ANTISERUM; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING DISORDER; BLOOD TOXICITY; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; ENVENOMATION; HEART OUTPUT; HEMOLYSIS; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; MALE; NEUROTOXICITY; NONHUMAN; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RHABDOMYOLYSIS; SNAKE; SWINE; THROMBOCYTOPENIA; TOXIN ANALYSIS; TREATMENT OUTCOME;

BOVINAE; MICROPECHIS IKAHEKA; PSEUDECHIS; PSEUDECHIS AUSTRALIS; SERPENTES;

EID: 0242321189     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2003.09.002     Document Type: Article

References (18)

1. Blasco P., Hornabrook R.W. Papua New Guinea Med. J. 15:1972;155-156.
2. Broad A.J., Sutherland S.K., Coulter A.R. The lethality in mice of dangerous Australian and other snake venoms. Toxicon. 17:1979;661-664.
3. Crachi M.T., Hammer L.W., Hodgson W.C. The effects of antivenom on the in vitro neurotoxicity of venoms from the taipans Oxyuranus scutellatus, Oxyuranus microlepidotus and Oxyuranus scutellatus canni. Toxicon. 37:1999;1771-1778.
4. Gao R., Kini R.M., Gopalakrishnakone P. Purification, properties, and amino acid sequence of a hemoglobinuria-inducing phospholipase A2, MiPLA-1, from Micropechis ikaheka venom. Arch. Biochem. Biophys. 369:1999;181-192.
5. 2 isoenzymes from Micropechis ikaheka venom. Biochim. Biophys. Acta. 1545:2001;30-40.
6. Gao R., Kini R.M., Gopalakrishnakone P. A novel prothrombin activator from the venom of Micropechis ikaheka: isolation and characterization. Arch. Biochem. Biophys. 408:2002;87-92.
7. 2 and neurotoxic activities in the venom of the New Guinean Small-eyed snake (Micropechis ikaheka). Toxicon. 35:1997;101-109.
8. Gutierrez J.M., Rojas G., Lomonte B., Gene J.A., Chaves F., Alvarado J., Rojas E. Standardisation of assays for testing the neutralizing ability of antivenoms. Toxicon. 28:1990;1127-1129.
9. Hannon J.P., Bossone C.A., Wade C.E. Normal physiological values for conscious pigs used in biomedical research. Lab. Animal Sci. 40:1990;293-298.
10. Hodgson W.C., Eriksson C.O., Alewood P.F., Fry B.G. Comparison of the in vitro neuromuscular activity of venom from three Australian snakes (Hoplocephalus stephensi, Austrelaps superbus and Notechis scutatus): efficacy of tiger snake antivenom. Clin. Exp. Pharmacol. Physiol. 30:2003;127-132.
11. Hudson B.J. The small-eyed snake (Micropechis ikaheka): a review of current knowledge. Papua New Guinea Med. J. 31:1988;173-178.
12. Hudson B.J., Pomat K. Ten years of snake bite in Madang Province. Papua New Guinea Trans. R. Soc. Trop. Med. Hyg. 82:1988;506-508.
13. O'Shea M. A guide to the snakes of Papua New Guinea. 1996;Independent Publishing, Port Moresby.
14. Ponraj D., Gopalakrishnakone P. Establishment of an animal model for myoglobinuria by use of a myotoxin from Pseudechis australis (King Brown Snake) venom in mice. Lab. Animal Sci. 46:1996;393-398.
15. Sundell I.B., Theakston R.D.G., Kamiguti A.S., Harris R.J., Treweeke A.T., Laing G.D., Fox J.W., Warrell D.A., Zuzel M. The inhibition of platelet aggregation and blood coagulation by Micropechis ikaheka venom. Br. J. Haematol. 114:2001;852-860.
16. Sutherland S.K., Tibballs J. Australian Animal Toxins. 2001;Oxford University Press, Melbourne.
17. Warrell D.A., Hudson B.J., Lalloo D.G., Trevett A.J., Whitehead P., Bamler P.R., Ranaivoson M., Wiyono A., Richie T.L., Fryauff D.J., O'Shea M.T., Richards A.M., Theakston R.D.G. The emerging syndrome of envenoming by the New Guinea small-eyed snake Micropechis ikaheka. Q. J. Med. 89:1996;523-530.
18. Wickramaratna J.C., Hodgson W.C. A pharmacological examination of venoms from three species of death adder (Acanthopis antarcticus, Acanthopis praelongus and Acanthopis pyrrhus). Toxicon. 39:2001;209-216.