Antileishmanial properties of Allium sativum extracts and derivatives

Acta Horticulturae

Volumn 426, Issue , 1996, Pages 183-191

  McClure, Christopher D ^a   Nolan, Linda L ^a   Zatyrka, Simon A ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Allicin; Allium sativum; Chemotherapeutic; Leishmaniasis

Indexed keywords

ALLIUM SATIVUM; LEISHMANIA DONOVANI CHAGASI; MAMMALIA;

EID: 0242319182     PISSN: 05677572     EISSN: None     Source Type: Book Series    
DOI: 10.17660/actahortic.1996.426.22     Document Type: Conference Paper

References (21)

1. Belman, S., E. Block, and G. Barany. 1989. Inhibition of mouse skin tumorigene-sis promotion by onion and garlic oils. /. Biochem. Toxicol. 4(3): 151-161.
2. Berman, J.D. 1988. Chemotherapy for leishmaniasis: Biochemical mechanisms. Rev. infect. Diseases. 10:560-586.
3. Elnima, E.I., S.A. Ahmed, A. Mekkawi, and J.S. Mossa. 1989. The antimicrobial activity of garlic and onion extracts. Pharmazie. 38:747-748.
4. Feldberg, R.S., S.C. Chang, A.N. Kotik, M. Nadler, R. Neuwirth, D.C. Sund-strom, and N.H. Thompson. 1988. In vitro mechanism of inhibition of bacterial cell growth by allicin. Antimicro. Agents Chemothera. 32(12): 1763-1768.
5. Focke, M., A. Feld, and H.K. Lichtenthaler. 1990. Allicin, a naturally occurring antibiotic from garlic, specifically inhibits acetyl-CoA synthetase. FEBS. 261(1): 106-108.
6. Hammer, S., A. Dorfman, and A. Wilbur. 1985. To conquer cancer. Sci. Digest. 119902:1763-1768.
7. Hughes, B.G. and L.D. Lawson. 1991. Antimicrobial effects of Allium sativum L. (garlic), Allium ampeloprasum L. (elephant garlic), and Allium cepa (onion), garlic components and commercial garlic supplement products. Phytothera. Res. 5:154-158.
8. Iberl, B., G. Winkler, and K. Knobloch. 1990. Products of allicin transformation: Ajoenes and dithiins, characterization and determination by HPLC. Planta Medica. 56:202-211.
9. Lainson, R. and J.J. Shaw. 1978. Epidemiology and ecology of leishmaniasis in Latin America. Nature 272:595-600.
10. Lau, B.H., M.A. Adetumbi, and A. Sanchez. 1983. Allium sativum (garlic) and atherosclerosis: A review. Nutr. Res. 3:119-128.
11. Lawson, L.D. 1992. Bioactive organosulfur compounds of garlic and garlic products. ACS Symposium Series, Chapter 21, pp. 306-330.
12. Lawson, L.D., S.G. Wood, and B.G. Hughes. 1991. HPLC analysis of allicin and other thiosulfinates in garlic clove homogenates. Planta Medica. 57:263-270.
13. Moore, G.S. and R.D. Atkins. 1977. The fungicidal and fungistatic effects of an aqueous garlic extract on medicinally important yeast-like fungi. Mycologica. 2:341-348.
14. Nakagawa, S., S. Yoshida, Y. Hirao, S. Kasuga, and T. Fuwa. 1985. Cytopro-tective activity of components of garlic, ginseng, and ciuwjia on hepatocyte injury induced by carbon tetrachloride in vitro. Hiroshima J. Med. Sci. (Japan). 34:303-309.
15. Perchellet, J.P., E.M. Perchellet, and S. Belman. 1990. Inhibition of DMBA induced mouse skin tumorigenesis by garlic oil. Nutr. Cancer. 14:183-193.
16. Sharma, V.D., M.S. Sethi, A. Kramer, and J.R. Rarotra. 1977. Antimicrobial properties of Allium sativum Linn. Ind. J. Exp. Biol. 15:466-480.
17. Redinbaugh, M.G. and W.H. Campbell. 1985. Adaptation of the dye-binding protein assay to microliter plates. Anal. Blochem. 147:144-147.
18. Reichenber, J. 1984. A scientific basis for the active principal of garlic {Allium sativum) and its use as a hypocholestrolemic and antibacterial/antifungal agent. J. John Bastyr Col. Nat. Med. 2:28-32.
19. Tsai, Y., L.L. Cole, L.E. Davis, S.J. Lockwood, V. Simmons, and G.C. Wild. 1985. Antiviral properties of garlic: In vitro effects on influenza B, herpes simplex and Coxsackie viruses. Planta Medica 5:460-461.
20. Willis, B.G. 1956. Enzyme inhibition by allicin, the active principal of garlic. Biochem. 63:514-520.
21. Xing, M., et al. 1982. Gastric cancer, the effect of garlic on nitrite and nitrate in gastric juices. Acta Nutri. Sin. 4:53-57.