Pathophysiology of Alcohol-Induced Pancreatic Injury

Pancreas

Volumn 27, Issue 4, 2003, Pages 327-331

  Saluja, Ashok K ^a   Bhagat, Lakshmi ^b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b NONE

Author keywords

Acinar cells; Cholecystokinin; Cholecystokinin releasing factor; Digestive enzyme secretion; Ethanol; Pancreatitis

Indexed keywords

ALCOHOL; CHOLECYSTOKININ; TRYPSIN;

ALCOHOL CONSUMPTION; ALCOHOLIC PANCREATITIS; ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; CIGARETTE SMOKING; ENZYME RELEASE; FAT INTAKE; GENETIC PREDISPOSITION; HUMAN; NONHUMAN; PANCREAS INJURY; PANCREATITIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; VIRUS INFECTION;

AMYLASES; ANIMALS; CHOLECYSTOKININ; DEVAZEPIDE; ETHANOL; HORMONE ANTAGONISTS; HUMANS; PANCREAS; PANCREATITIS, ALCOHOLIC; RATS; RECEPTOR, CHOLECYSTOKININ A; TIME FACTORS;

EID: 0242317844     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-200311000-00010     Document Type: Article

References (41)

1. Apte MV, Haber PS, Applegate TL, et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut. 1998;43:128-133.
2. Phillips PA, McCarroll JA, Park S, et al. Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover. Gut. 2003;52:275-282.
3. Rinderknecht H, Stace NH, Renner IG. Effects of chronic alcohol abuse on exocrine pancreatic secretion in man. Dig Dis Sci. 1985;30:65-71.
4. Sahel J, Sarles H. Modifications of pure human pancreatic juice induced by chronic alcohol consumption. Dig Dis Sci. 1979;24:897-905.
5. Lerch MM, Saluja AK, Dawra R, et al. The effect of chloroquine administration on two experimental models of acute pancreatitis. Gastroenterology. 1993;104:1768-1779.
6. Lu Z, Kame S, Kolodecik T, et al. Alcohols enhance caerulein-induced zymogen activation in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol. 2002;282:G501-G507.
7. Gukovskaya AS, Mouria M, Gukovsky I, et al. Ethanol metabolism and transcription factor activation in pancreatic acinar cells in rats. Gastroenterology. 2002;122:106-118.
8. Wemer J, Saghir M, Warshaw AL, et al. Alcoholic pancreatitis in rats: injury from nonoxidative metabolites of ethanol. Am J Physiol Gastrointest Liver Physiol. 2002;283:G65-G73.
9. Singh M, Simsek H. Ethanol and the pancreas. Current status. Gastroenterology. 1990;98:1051-1062.
10. Steer ML, Glazer G, Manabe T. Direct effects of ethanol on exocrine secretion from the in vitro rabbit pancreas. Dig Dis Sci. 1979;24:769-774.
11. Solomon N, Solomon TE, Jacobson ED, et al. Direct effects of alcohol on in vivo and in vitro exocrine pancreatic secretion and metabolism. Am J Dig Dis. 1974;19:253-260.
12. Lewin MB, Sankaran H, Deveney CW, et al. Effect of ethanol on cholecystokinin-induced enzyme secretion from isolated rat pancreatic acini. Biochem Pharmacol. 1984;33:3225-3229.
13. Sankaran HLM, Wong A, Deveney CW, et al. Effects of Ca ionophore A23187 on ethanol and acetaldehyde inhibition of cholecystokinin-stimulated amylase secretion from isolated rat pancreatic acini. Biochem Arch. 1987;3:295-299.
14. Ponnappa BC, Hoek JB, Waring AJ, et al. Effect of ethanol on amylase secretion and cellular calcium homeostasis in pancreatic acini from normal and ethanol-fed rats. Biochem Pharmacol. 1987;36:69-79.
15. Fitzpatrick JM, Fitzgerald O, Fitzgerald P, et al. A study of ethanol action on the totally isolated canine pancreas. Bull Soc Int Chir. 1975;34:593-599.
16. Apte M, Norton I, Haber P, et al. The effect of ethanol on pancreatic enzymes - a dietary artefact? Biochim Biophys Acta. 1998;1379:314-324.
17. Tiscomia OM, Gullo L, de Barros Mott C, et al. et al. The effects of intragastric ethanol administration upon canine exocrine pancreatic secretion. Digestion, 1973;9:490-501.
18. Tiscomia OM, Gullo L, Sarles H, et al. Effects of intragastric and intraduodenal ethanol on canine exocrine pancreatic secretion. Digestion. 1974;10:52-60.
19. Mott C, Sarles H, Tiscomia O, et al. Inhibitory action of alcohol on human exocrine pancreatic secretion. Am J Dig Dis. 1972;17:902-910.
20. Marin GA, Ward NL, Fischer R. Effect of ethanol on pancreatic and biliary secretions in humans. Am J Dig Dis. 1973;18:825-833.
21. Bayer M, Rudick J, Lieber CS, et al. Inhibitory effect of ethanol on canine exocrine pancreatic secretion. Gastroenterology. 1972;63:619-626.
22. Tiscomia O 0, Gullo L, Sarles H. The inhibition of canine exocrine pancreatic secretion by intravenous ethanol. Digestion. 1973;9:231-240.
23. Lowenfels AB, Masih B, Lee TC, et al. Effect of intravenous alcohol on the pancreas. Arch Surg. 1968;96:440-441.
24. Korsten MA, Seitz H, Hodes SF, et al. Effect of intravenous ethanol on pancreatic secretion in the conscious rat. Dig Dis Sci. 1981;26:790-795.
25. Singh M. Ethanol and pancreas. In: Go VLW, DiMagno EP, Gardner JD, et al, eds. The exocrine pancreas: biology, pathobiology and diseases. New York: Raven Press, 1986:423-442.
26. Fitzpatrick JFO, Fitzgerald P, McGeeney KF. The effect of acetaldehyde on the totally isolated canine pancreas. Biol Gastroenterol. 1975;64:363.
27. Andersen BN, Demol P, Treffot MJ, et al. The effect of acetaldehyde on pancreatic and gastric secretion. Scand J Gastroenterol. 1980;15:805-809.
28. Demol P, Andersen BN, Sarles H. Chronic ethanol consumption and exocrine pancreatic response to ethanol and acetaldehyde in the rat. Digestion. 1980;20:85-94.
29. Llanos OL, Swierczek JS, Teichmann RK, et al. Effect of alcohol on the release of secretin and pancreatic secretion. Surgery. 1977;81:661-667.
30. Nishiwaki H, Lee KY, Chey WY. Effect of alcohol on plasma secretin concentration and pancreatic secretion in dogs. Surgery. 1984;95:85-89.
31. Fahrenkrug J, Schaffalitzky de Muckadell OB. Plasma secretin concentration in man: effect of intraduodenal glucose, fat, amino acids, ethanol, HC1, or ingestion of a meal. Eur J Clin Invest. 1977;7:201-203.
32. Fried GM, Ogden WD, Zhu XG, et al. Effect of alcohol on the release of cholecystokinin and pancreatic enzyme secretion. Am J Surg. 1984;147:53-57.
33. Singer MV, Eysselein V, Goebell H. Pancreatic polypeptide response to ethanol in humans and dogs. Regul Pept. 1983;6:13-23.
34. Staub JL, Sarles H, Chayvialle JA, et al. Relationship between intravenous ethanol, alcohol-induced inhibition of pancreatic secretion and plasma concentration of immunoreactive pancreatic polypeptide, vasoactive intestinal peptide, and somatostatin in man. Regul Pept. 1981;2:61-68.
35. Schmidt DN. Does ethanol exert its effect on the canine pancreas by mediation of cholinergic nerves? Scand J Gastroenterol Suppl. 1986;126:69-74.
36. Sarles H, Johnson C, Devaux MA, et al. Influence of environmental conditions on exocrine pancreatic response to intravenous injection of ethanol or 2-deoxyglucose in the dog. Dig Dis Sci. 1984;29:19-25.
37. Tiscomia OM, Palasciano G, Dzieniszewski J. Simultaneous changes in pancreatic and gastric secretion induced by acute intravenous ethanol infusion. Effect of atropine and reserpine. Am J Gastroenterol. 1975;63:389-395.
38. Saluja AK, Lu L, Yamaguchi Y, et al. A cholecystokinin-releasing factor mediates ethanol-induced stimulation of rat pancreatic secretion. J Clin Invest. 1997;99:506-512.
39. Liddle RA, Goldfine ID, Williams JA. Bioassay of plasma cholecystokinin in rats: effects of food, trypsin inhibitor, and alcohol. Gastroenterology. 1984;87:542-549.
40. Rinderknecht H, Renner IG, Koyama HH. Lysosomal enzymes in pure pancreatic juice from normal healthy volunteers and chronic alcoholics. Dig Dis Sci. 1979;24:180-186.
41. Apte MV, Norton ID, Wilson JS. Ethanol induced acinar cell injury. Alcohol Alcohol Suppl. 1994;2:365-368.