Comparison of the Flow Properties of Aqueous Suspension Corticosteroid Nasal Sprays Under Differing Sampling Conditions

Drug Development and Industrial Pharmacy

Volumn 29, Issue 9, 2003, Pages 1005-1012

  Sharpe, S A ^a   Sandweiss, V ^a   Tuazon, J ^a   Giordano, M ^a   Witchey Lakshmanan, L ^a   Hart, J ^a   Sequeira, J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Corticosteroid; Nasal sprays; Rheological properties; Thixotropy; Viscosity

Indexed keywords

BECLOMETASONE DIPROPIONATE; BUDESONIDE; CORTICOSTEROID; FLUTICASONE PROPIONATE; MOMETASONE FUROATE; NASACORT AQ; TRIAMCINOLONE ACETONIDE; WATER;

AEROSOL; AQUEOUS SOLUTION; ARTICLE; CHEMISTRY; COMPARATIVE STUDY; FLOW; FLOW KINETICS; INTRANASAL DRUG ADMINISTRATION; SAMPLING; SHEAR RATE; SHEAR STRENGTH; SIMULATION; SUSPENSION; THIXOTROPY; VISCOSITY;

ADMINISTRATION, INTRANASAL; ADRENAL CORTEX HORMONES; CHEMISTRY, PHARMACEUTICAL; SHEAR STRENGTH; SUSPENSIONS; VISCOSITY; WATER;

EID: 0242290009     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-120025457     Document Type: Article

References (17)

1. van Cauwenberge, P.; Bachert, C.; Passalacqua, G.; Bousquet, J.; Canonica, G.W.; Durham, S.R.; Fokkens, W.J.; Howarth, P.H.; Lund, V.; Malling, H.J.; Mygind, N.; Passali, D.; Scadding, G.K.; Wang, D.Y. Consensus statement on the treatment of allergic rhinitis. European Academy of Allergology and Clinical Immunology. Allergy 2000, 55 (2), 116-134.
2. Mandl, M.; Nolop, K.; Lutsky, B.N. Comparison of once daily mometasone furoate (Nasonex) and fluticasone propionate aqueous nasal sprays for the treatment of perennial rhinitis. Ann. Allergy Asthma Immunol. 1997, 79 (4), 370-378.
3. Meltzer, E.O.; Jalowayski, A.A.; Orgel, H.A.; Harris, A.G. Subjective and objective assessments in patients with seasonal allergic rhinitis: effects of therapy with mometasone furoate nasal spray. J. Allergy Clin. Immunol. 1998, 102 (1), 39-49.
4. Minshall, E.; Ghaffar, O.; Cameron, L.; O'Brien, F.; Quinn, H.; Rowe-Jones, J.; Davies, R.J.; Prior, A.; Lund, V.J.; Mackay, I.S.; Nolop, K.; Lutsky, B.; Durham, S.R.; Hamid, Q. Assessment by nasal biopsy of long-term use of mometasone furoate aqueous nasal spray (Nasonex) in the treatment of perennial rhinitis. Otolaryngol. Head Neck Surg. 1998, 118 (5), 648-654.
5. Eccleston, G.M.; Bakhshaee, M.; Hudson, N.E.; Richards, D.H. Rheological behavior of nasal sprays in shear and extension. Drug Dev. Ind. Pharm. 2000, 26 (9), 975-983.
6. Martin, A.N.; Banker, G.S. Rheology. Adv. Pharm. Sci. 1964, 1, 1-85.
7. Pryce-Jones, J. J. Sci. Instrum. 1941, 18, 39.
8. Green, H.; Weltman, R.N. Ind. Eng. Chem. Anal. Ed. 1943, 424.
9. Bauer, W.H.; Collins, E.A. Rheology: Theory and Applications; Eirich, F.R., Ed.; Academic Press: New York, 1967; Vol. 4, Ch. 8.
10. Thelwis, J., Ed. Oxford Encyclopedia Dictionary of Physics; Pergamon Press: Oxford, 1962.
11. Collocott, T.C., Ed. Chambers Dictionary of Science and Technology; W & R Chambers: Edinburgh, 1971.
12. Vancenase® AQ 84 mcg nasal spray product information. Schering Corporation: Kenilworth, NJ, 1997.
13. Nasacort® AQ nasal spray product information. Aventis Pharmaceuticals, Inc.: Collegeville, PA, 1997.
14. Nasonex® aqueous nasal spray product information. Schering Corporation: Kenilworth, NJ, 1999.
15. Rhinocort Aqua® nasal spray product information. AstraZeneca LP: Wilmington, DE, 2001.
16. Flonase® nasal spray product information. GlaxoSmithKline: Research Triangle Park, NC, 2001.
17. Eccleston, G.M.; Hudson, N.E. The use of a capillary rheometer to determine the shear and extensional flow behavior of nasal spray suspensions. J. Pharm. Pharmacol. 2000, 52 (10), 1223-1232.