Methaemoglobinaemia and haemolysis associated with hydrogen peroxide in a paediatric haemodialysis centre: A warning note

Nephrology Dialysis Transplantation

Volumn 18, Issue 11, 2003, Pages 2354-2358

  Davidovits, Miriam ^a,c   Barak, Ayala ^b   Cleper, Roxana ^a   Krause, Irit ^a,c   Gamzo, Zahava ^a,c   Eisenstein, Bella ^a,c  

^a SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^b Aylab Ltd   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

Children; Haemodialysis; Haemolysis; Hydrogen peroxide; Methaemoglobinaemia

Indexed keywords

CHLORINE; DIALYSIS FLUID; HAPTOGLOBIN; HEMOGLOBIN; HYDROGEN PEROXIDE; TAP WATER; TOSYLCHLORAMIDE SODIUM;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; COLORIMETRY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIALYSATE; HEMODIALYSIS; HEMOGLOBIN DETERMINATION; HUMAN; METHEMOGLOBINEMIA; PRIORITY JOURNAL; STATISTICAL ANALYSIS; WATER CONTAMINATION; WATER SUPPLY; WATER TREATMENT;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CHLORAMINES; CHLORINE; DISINFECTANTS; HEMODIALYSIS SOLUTIONS; HEMOLYSIS; HUMANS; HYDROGEN PEROXIDE; METHEMOGLOBINEMIA; RENAL DIALYSIS; WATER PURIFICATION;

EID: 0242288592     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/gfg395     Document Type: Article

References (23)

1. Keshavia P. Water treatment for hemodialysis. In: Henderson LW, Thuma RS eds. Quality Assurance in Dialysis. Kluwer Academic Publishers, The Netherlands: 1994; 85-87
2. Klein E. Effects of disinfectants in renal dialysis patients. Envir Health Persp 1986; 69: 45-47
3. Association for the Advancement of Medical Instrumentation, AAMI. American National Standards for Hemodialysis Systems. Arlington Press, Arlington, VA: 1981
4. American Public Health Association, APHA. Standard Methods for the Examination of Water and Waste Water, 17th edn. American Public Health Association, Washington, DC: 1989
5. Public Health Regulations, Israeli Ministry of Health, 1995
6. Harp DL. Current technology of chlorine analysis for water and waste water. Technical Information Series, Booklet No. 17. Hach Company, Loveland, CO, USA, 1995
7. Eaton JW, Kolpin CD, Swofford HS, Kjellstrand CM, Jacob HS. Chlorinated urban water: a cause of dialysis-induced hemolytic anemia. Science 1973; 181: 463-464
8. Kjellstrand CM, Eaton JW, Yawata Y et al. Hemolysis in dialyzed patients caused by chloramines. Nephron 1974; 13: 427-433
9. Tipple MA, Shusterman N, Bland LA. Illness in hemodialysis patients following exposure to chloramine-contaminated dialysate. ASAIO Trans 1991; 37: 588-591
10. Alayash AI, Patel RP, Cashon RE. Redox reactions of hemoglobin and myoglobin: biological and toxicological implications. Antioxidants Redox Signal 2001; 3: 313-327
11. Snyder LM, Fortier NL, Trainor J et al. Effect of hydrogen peroxide exposure on normal human erythrocyte deformability, morphology, surface characteristics, and spectrin-hemoglobin cross-linking. J Clin Invest 1985; 76: 1971-1977
12. Winterbourn CC. Toxicity of iron and hydrogen peroxide: the Fenton reaction. Toxicol Lett 1995; 82-83: 969-974
13. 2-removing enzyme in human erythrocytes. Blood 1997; 90: 4973-4978
14. Tudhope GR. Red cell catalase in health and in disease, with reference to the enzyme activity in anaemia. Clin Sci 1967; 33: 165-182
15. Sleigh JW, Linter SPK. Hazards of hydrogen peroxide. Br Med J 1985; 291: 1706
16. Ellis DG, Clatworthy HW. The meconium plug syndrome revisited. J Pediatr Surg 1966; 1: 54-61
17. Rackoff WR, Merton DF. Gas embolism after ingestion of hydrogen peroxide. Br Med J 1990; 85: 593-594
18. Fuson RL, Kylstra JA, Hochstein P, Saltzman HA. Intravenous hydrogen peroxide as a means of extrapulmonary oxygenation. Clin Res 1967; 15: 74
19. Hirschtick RE, Dyrda SE, Peterson LC. Death from an unconventional therapy for AIDS. Ann Int Med 1994; 120: 694
20. Gordon SM, Bland LA, Alexander SR, Newman HF, Arduino MJ, Jarvis WR. Hemolysis associated with hydrogen peroxide at a pediatric dialysis center. Am J Nephrol 1990; 10: 123-127
21. Arduino MJ. CDC investigations of noninfectious outbreaks of adverse events in hemodialysis facilities, 1979-1999. Semin Dial 2000; 13: 86-91
22. Divanon F, Leroyer R, Hamel F, Jehan C, Samba D. Methemoglobinemia probably due to Dialox R during hemodialysis. Pharm Hosp 2001; 6: 31-35
23. Merckoquant, Peroxide Test. Merck KGaA 64271, Darmstadt, Germany