Tachyphylactic properties of angiotensin II analogs with bulky and hydrophobic substituents at the N-terminus

Journal of Peptide Research

Volumn 62, Issue 5, 2003, Pages 227-232

  Motta, S C ^a   Poletti, E F ^a   Souza, S E G ^a   Correa, S A A ^a   Jubilut, G N ^a   Paiva, A C M ^a   Shimuta, S I ^a   Nakaie, C R ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Analogs; Angiotensin II; AT1 receptor; Tachyphylaxis

Indexed keywords

9 FLUORENYLMETHYL CHLOROFORMATE; 9 FLUORENYLMETHYL ESTER; ANGIOTENSIN II DERIVATIVE; ANGIOTENSIN RECEPTOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; GUINEA PIG; HYDROPHOBICITY; ILEUM; LIPOPHILICITY; MUSCLE EXCITATION; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE; TACHYPHYLAXIS;

ANGIOTENSIN II; ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GUINEA PIGS; HYDROPHOBICITY; ILEUM; MUSCLE CONTRACTION; MUSCLE, SMOOTH; OLIGOPEPTIDES; RADIOLIGAND ASSAY; RECEPTOR, ANGIOTENSIN, TYPE 1; STRUCTURE-ACTIVITY RELATIONSHIP; TACHYPHYLAXIS;

ANIMALIA; CAVIA PORCELLUS; CRICETINAE; CRICETULUS GRISEUS; SUS SCROFA;

EID: 0242270006     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.2003.00091.x     Document Type: Article

References (17)

1. De Gasparo, M., Catt, K.J., Inagami, T., Wright, J.W. & Unger, T.H. (2000) International union of pharmacology. The angiotensin II receptors. Pharmacol. Rev. 52, 415-472.
2. Guo, D.F., Sun, Y.L., Hamet, P. & Inagami, T. (2001) The angiotensin II type 1 receptor and receptor-associated proteins. Cell Res. 11, 165-180
3. Stewart, J.M. (1974) Tachyphylaxis to angiotensin. In: Angiotensin (Page, I.H. & Bumpus, F.M., eds), pp. 170-184. Springer, Berlin.
4. Paiva, T.B., Miyamoto, M.E., Juliano, L. & Paiva, A.C.M. (1977) Requirements for angiotensin tachyphylaxis in smooth muscle. J. Pharmacol. Exp. Ther. 202, 294-300
5. + and protein kinase C in angiotensin desensibilization and tachyphylaxis in the guinea-pig ileum. Naunyn-Schmiedeberg's Arch. Pharmacol. 347, 425-431.
6. Kanashiro, C.A., Paiva, T.B., Paiva, A.C.M., Prioste, R.N., Aboulafia, J. & Shimuta, S.I. (1995) Angiotensin II tachyphylaxis in the guinea-pig ileum and its prevention: a pharmacological and biochemical study. J. Pharmacol. Exp. Ther. 275, 1543-1550
7. Moore, G.J., Franklin, K.J., Nystron, D.M. & Goghari, M.H. (1985) Structure-desensitization relationships of angiotensin analogs in the rat isolated uterus. Can. J. Physiol. Pharmacol. 63, 966-971.
8. Hunyady, L., Balla, T. & Catt, K.J. (1966) The ligand binding site of the angiotensin AT1 receptor. Trends Pharmacol. Sci. 17, 135-140.
9. Paiva, T.B., Juliano, L., Nouailhetas, V.L.A. & Paiva, A.C.M. (1974) The effect of pH on tachyphylaxis to angiotensin peptides in the isolated guinea pig ileum and rat uterus. Eur. J. Pharmacol. 25, 191-196.
10. Miasiro, N., Oshiro, M.E.M., Paiva, T.B. & Paiva, A.C.M. (1983) Role of the two N-terminal residues of angiotensin II in the production of tachyphylaxis. Eur. J. Pharmacol. 87, 397-406.
11. Oshiro, M.E.M., Miasiro, N., Paiva, T.B. & Paiva, A.C.M. (1984) Angiotensin tachyphylaxis in the isolated rabbit aorta. Blood Vessels 21, 72-79.
12. Carpino, L.A. & Han, G.Y. (1970) 9-fluorenylmethocarbonyl function, a new base-sensitive amino-protecting group. J. Am. Chem. Soc. 92, 5748-5750.
13. Atherton, E. & Sheppard, R.C. (1989) Solid Phase Peptide Synthesis: A Practical Approach. I.L.R. Press, Oxford.
14. Fields, G.B. & Noble, R.L. (1990) Solid phase peptide-synthesis utilizing 9-fluorenylmethoxycarbonyl-amino acids. Int. J. Pept. Protein Res. 35, 161-214.
15. 1 receptor are not involved in ligand binding but participate in signal transduction. Mol. Endocrinol. 12, 810-814.
16. Barany, G. & Merrifield, R.B. (1980) Solid phase peptide approach. In: The Peptides: Analysis, Synthesis and Biology (Gross, E. & Meienhofer, J., eds), Vol. 2, pp. 1-284. Academic Press, New York.
17. Shimuta, S.I., Nakaie, C. R., Paiva, A.C.M., Cordopatis, P. & Theodoropoulos, D. (1989) Changes in residues 1 and 4 of angiotensin II affect differently its agonist and tachyphylactic properties. Naunyn-Schmiedeberg's Arch. Pharmacol. 340, 309-313.