Mechanisms and consequences of silica-induced apoptosis

Toxicological Sciences

Volumn 76, Issue 1, 2003, Pages 1-2

  McCabe Jr , Michael K ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE 3; CASPASE 9; CASPASE INHIBITOR; CYCLOSPORIN A; SILICON DIOXIDE;

APOPTOSIS; ARTICLE; CELL COMPARTMENTALIZATION; CONCENTRATION (PARAMETERS); ENZYME ACTIVATION; ENZYME ASSAY; HUMAN; IMMUNOBLOTTING; IMMUNOPATHOLOGY; INFLAMMATION; LUNG ALVEOLUS MACROPHAGE; LUNG FIBROSIS; LUNG INJURY; MITOCHONDRION; MOLECULAR MECHANICS; OCCUPATIONAL DISEASE; SIGNAL TRANSDUCTION; SILICOSIS;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELLS, CULTURED; HUMANS; SILICON DIOXIDE; SILICOSIS;

EID: 0242268508     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg246     Document Type: Article

References (5)

1. Borges, V. M., Lopes, M. F., Falcao, H., Leite-Junior, J. H., Rocco, P. R., Davidson, W. F., Linden, R., Zin, W. A., and DosReis, G. A. (2002). Apoptosis underlies immunopathogenic mechanisms in acute silicosis. Am. J. Respir. Cell Mol. Biol. 27, 78-84.
2. Mossman, B. T. and Churg, A. (1998). Mechanisms in the pathogenesis of asbestosis and silicosis. Am. J. Respir. Crit Care Med. 157, 1666-1680.
3. Reiners, J. J., Jr., Caruso, J. A., Mathieu, P., Chelladurai, B., Yin, X. M., and Kessel, D. (2002). Release of cytochrome c and activation of pro-caspase-9 following lysosomal photodamage involves Bid cleavage. Cell Death. Differ. 9, 934-944.
4. Rosenman, K. D., Reilly, M. J., and Henneberger, P. K. (2003). Estimating the total number of newly-recognized silicosis cases in the United States. Am. J. Ind. Med. 44, 141-147.
5. Shen, H. M., Zhang, Z., Zhang, Q. F., and Ong, C. N. (2001). Reactive oxygen species and caspase activation mediate silica-induced apoptosis in alveolar macrophages. Am. J. Physiol Lung Cell Mol. Physiol 280, L10-L17.