Development of a mechanical testing and loading system for trabecular bonestudies for long term culture

European Cells and Materials

Volumn 5, Issue , 2003, Pages 48-60

  Jones, David B ^a   Broeckmann, E ^a   Pohl, T ^a   Smith, E L ^b   Gasser, J ^c   Prendergast, P ^c  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c NONE

Author keywords

Biological stimulation; Static and dynamic mechanical loading; Stiffness measurements; Trabecular bone diffusion; Young's Modulus

Indexed keywords

ACCURACY; ARTICLE; BONE DEFORMATION; CALIBRATION; COMPRESSIVE STRENGTH; DIFFUSION CHAMBER; ELECTRONIC SENSOR; FORCE; INFORMATION PROCESSING; LOADING TEST; MATERIALS TESTING; PIEZOELECTRICITY; QUALITY CONTROL; REPRODUCIBILITY; TIME; TRABECULAR BONE; VISCOELASTICITY; ANIMAL; BIOLOGICAL MODEL; BIOPHYSICS; BONE; CATTLE; CHEMISTRY; CULTURE TECHNIQUE; ELECTRODE; ELECTROPHYSIOLOGY; HUMAN; INSTRUMENTATION; MECHANICAL STRESS; METABOLISM; METHODOLOGY; PHYSIOLOGY; STANDARD; VALIDATION STUDY; WEIGHT BEARING;

ANIMALS; BIOPHYSICS; BONE AND BONES; CALIBRATION; CATTLE; CULTURE TECHNIQUES; DIFFUSION CHAMBERS, CULTURE; ELECTRODES; ELECTROPHYSIOLOGY; HUMANS; MODELS, BIOLOGICAL; QUALITY CONTROL; RESEARCH DESIGN; STRESS, MECHANICAL; WEIGHT-BEARING;

EID: 0142258994     PISSN: 14732262     EISSN: None     Source Type: Journal    
DOI: 10.22203/eCM.v005a05     Document Type: Article

References (14)

1. Akhter MP, Cullen DM, Recker RR (2002) Bone adaptation response to sham and bending stimuli in mice. J Clin Densitom 5: 207-216.
2. Botchwey EA, Pollack SR, Levine EM, Laurencin CT (2001) Bone tissue engineering in a rotating bioreactor using a microcarrier matrix system. J Biomed Mater Res 55: 242-253.
3. Cheng MZ, Zaman G, Rawlinson SC, Suswillo RF, Lanyon LE (1996) Mechanical loading and sex hormone interactions in organ cultures of rat ulna. J Bone Miner Res 11: 502-511.
4. Chow JW, Wilson AJ, Chambers TJ, Fox SW (1998) Mechanical loading stimulates bone formation by reactivation of bone lining cells in 13-week-old rats. J Bone Miner Res 13: 1760-1767.
5. El Haj AJ, Minter SL, Rawlinson SC, Suswillo R, Lanyon LE (1990) Cellular responses to mechanical loading in vitro. J Bone Miner Res 5: 923-932.
6. Jones DB, Leivseth G, Tenbosch J (1995) Mechano-reception in osteoblast-like cells. Biochem Cell Biol. 73: 525-534.
7. Rawlinson SC, Mosley JR, Suswillo RF, Pitsillides AA, Lanyon LE (1995) Calvarial and limb bone cells in organ and monolayer culture do not show the same early responses to dynamic mechanical strain. J Bone Miner Res 10: 1225-1232.
8. Rodan GA, Mensi T, Harvey A (1975) A quantitative method for the application of compressive forces to bone in tissue culture. Calcif Tissue Int 18: 125-131.
9. Rubin CT, Lanyon LE (1997) Kappa Delta Award paper. Osteoregulatory nature of mechanical stimuli: function as a determinant for adaptive remodeling in bone. J Orthop Res 5: 300-310.
10. Rubin CT, Turner AS, Muller R, Mittra E, McLeod K, Lin W, Qin YX (2002) Quantity and quality of trabecular bone in the femur are enhanced by a strongly anabolic, noninvasive mechanical intervention. J Bone Miner Res 17: 349-357.
11. Smith EL, Martens F, Koller K, Clark W, Jones DB (2000) The Effects of 20 Days of Mechanical Loading Plus PTH on The E-Modulus of Cow Trabecular Bone. J Bone Miner Res 15(Suppl 1): 247
12. Smith EL, Boudriot U, Daume B, Kratz M, Jones DB, Cullen D (2001) Long Term Perfusion Loading of Trabecular Bone Cores and Formation Rate. J Bone Miner Res 16 (Suppl 1): 195.
13. Yeh CK, Rodan GA (1984) Tensile forces enhance prostaglandin E synthesis in osteoblastic cells grown on collagen ribbons. Calcif Tissue Int 36 (Suppl 1): 67-71
14. Zaman G, Suswillo RF, Cheng MZ, Tavares IA, Lanyon LE (1997) Early responses to dynamic strain change and prostaglandins in bone-derived cells in culture. J Bone Miner Res 12: 769-777