Analysis of the small GTPase gene superfamily of arabidopsis

Plant Physiology

Volumn 131, Issue 3, 2003, Pages 1191-1208

  Vernoud, Vanessa ^a   Horton, Amy C ^b   Yang, Zhenbiao ^a   Nielsen, Erik ^b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c DONALD DANFORTH PLANT SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; GENES; HYDROLYSIS; PROTEINS;

PHYLOGENETIC ANALYSIS;

PLANTS (BOTANY);

ANIMALIA; ARABIDOPSIS; EUKARYOTA;

EID: 0142252552     PISSN: 00320889     EISSN: None     Source Type: Journal    
DOI: 10.1104/pp.013052     Document Type: Article

References (167)

1. Ach RA, Gruissem W (1994) A small nuclear GTP-binding protein from tomato suppresses a Schizosaccharomyces pombe cell-cycle mutant. Proc Natl Acad Sci USA 91: 5863-5867
2. Adams AE, Johnson DI, Longnecker RM, Sloat BF, Pringle JR (1990) CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae. J Cell Biol 111: 131-142
3. Albert S, Will E, Gallwitz D (1999) Identification of the catalytic domains and their functionally critical arginine residues of two yeast GTPase-activating proteins specific for Ypt/Rab transport GTPases. EMBO J 18: 5216-5225
4. Alexandrov K, Horiuchi H, Steele-Mortimer O, Seabra MC, Zerial M (1994) Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes. EMBO J 13: 5262-5273
5. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25: 3389-3402
6. Antonny B, Beraud-Dufour S, Chardin P, Chabre M (1997) N-Terminal hydrophobic residues of the G-protein ADP-ribosylation factor-1 insert into membrane phospholipids upon GDP to GTP exchange. Biochemistry 36: 4675-4684
7. Arabidopsis Genome Initiative (2000) Analysis of the genome sequence of the flowering plant Arabidopsis thatiana. Nature 408: 796-815
8. Arellano M, Coll PM, Perez P (1999) RHO GTPases in the control of cell morphology, cell polarity, and actin localization in fission yeast. Microsc Res Tech 47: 51-60
9. Balguerie A, Sivadon P, Bonneu M, Aigle M (1999) Rvs167p, the budding yeast homolog of amphiphysin, colocalizes with actin patches. J Cell Sci 112: 2529-2537
10. Barbacid M (1987) ras genes. Annu Rev Biochem 56: 779-827
11. Barlowe C, Orci L, Yeung T, Hosobuchi M, Hamamoto S, Salama N, Rexach MF, Ravazzola M, Amherdt M, Schekman R (1994) COPII: a membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum. Cell 77: 895-907
12. Bar-Peled U, Maltz E, Bruckental I, Folman Y, Kali Y, Gacitua H, Lehrer AR, Knight CH, Robinzon B, Voet H et al. (1995) Relationship between frequent milking or suckling in early lactation and milk production of high producing dairy cows. J Dairy Sci 78: 2726-2736
13. Batoko H, Zheng HQ, Hawes C, Moore I (2000) A rab1 GTPase is required for transport between the endoplasmic reticulum and Golgi apparatus and for normal Golgi movement in plants. Plant Cell 12: 2201-2218
14. Baxter-Burrell A, Yang Z, Springer PS, Bailey-Serres J (2002) RopGAP4-dependent Rop GTPase rheostat control of Arabidopsis oxygen deprivation tolerance. Science 296: 2026-2028
15. Bednarek SY, Reynolds TL, Schroeder M, Grabowski R, Hengst L, Gallwitz D, Raikhel NV (1994) A small GTP-binding protein from Arabidopsis thaliana functionally complements the yeast YPT6 null mutant. Plant Physiol 104: 591-596
16. Benli M, Doring F, Robinson DG, Yang X, Gallwitz D (1996) Two GTPase isoforms, Ypt31p and Ypt32p, are essential for Golgi function in yeast. EMBO J 15: 6460-6475
17. Bischoff F, Vahlkamp L, Molendijk A, Palme K (2000) Localization of AtROP4 and AtROP6 and interaction with the guanine nucleotide dissociation inhibitor AtRhoGDI1 from Arabidopsis. Plant Mol Biol 42: 515-530
18. Bogdanove AJ, Martin GB (2000) AvrPto-dependent Pto-interacting proteins and AvrPto-interacting proteins in tomato. Proc Natl Acad Sci USA 97: 8836-8840
19. Boguski MS, McCormick F (1993) Proteins regulating Ras and its relatives. Nature 366: 643-654
20. Bolte S, Schiene K, Dietz KJ (2000) Characterization of a small GTP-binding protein of the rab 5 family in Mesembryanthemum crystallinum with increased level of expression during early salt stress. Plant Mol Biol 42: 923-936
21. Boman AL (2001) GGA proteins: new players in the sorting game. J Cell Sci 114: 3413-3418
22. Bucci C, Parton RG, Mather IH, Stunnenberg H, Simons K, Hoflack B, Zerial M (1992) The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway. Cell 70: 715-728
23. Calhoun BC, Lapierre LA, Chew CS, Goldenring JR (1998) Rab11a redistributes to apical secretory canaliculus during stimulation of gastric parietal cells Am J Physiol 275: C163-C170
24. Carazo-Salas RE, Guarguaglini G, Gruss OJ, Segref A, Karsenti E, Mattaj IW (1999) Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation. Nature 400: 178-181
25. Cerione RA, Zheng Y (1996) The Db1 family of oncogenes. Curr Opin Cell Biol 8: 216-222
26. Chant J, Stowers L (1995) GTPase cascades choreographing cellular behavior: movement, morphogenesis, and more Cell 81: 1-4
27. Chardin P, Paris S, Antonny B, Robineau S, Beraud-Dufour S, Jackson CL, Chabre M (1996) A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains. Nature 384: 481-484
28. Chavrier P, Goud B (1999) The role of ARF and Rab GTPases in membrane transport. Curr Opin Cell Biol 11: 466-475
29. Cheung AY, Chen CY, Glaven RH, de Graaf BH, Vidali L, Hepler PK, Wu HM (2002) Rab2 GTPase regulates vesicle trafficking between the endoplasmic reticulum and the Golgi bodies and is important to pollen tube growth. Plant Cell 14: 945-962
30. Christoforidis S, McBride HM, Burgoyne RD, Zerial M (1999) The Rab5 effector EEA1 is a core component of endosome docking. Nature 397: 621-625
31. Clark J, Moore L, Krasinskas A, Way J, Battey J, Tamkun J, Kahn RA (1993) Selective amplification of additional members of the ADP-ribosylation factor (ARF) family: cloning of additional human and Drosophila ARF-like genes. Proc Natl Acad Sci USA 90: 8952-8956
32. Clarke PR, Zhang C (2001) Ran GTPase: a master regulator of nuclear structure and function during the eukaryotic cell division cycle? Trends Cell Biol 11: 366-371
33. Collins CC, Johnson DI (1997) An Arabidopsis thaliana expressed sequence tag cDNA that encodes a Rac-like protein (accession no. U88402). Plant Physiol 113: 1463
34. Cosson P, Letourneur F (1997) Coatomer (COPI)-coated vesicles: role in intracellular transport and protein sorting. Curr Opin Cell Biol 9: 484-487
35. Cuif MH, Possmayer F, Zander H, Bordes N, Jollivet F, Couedel-Courteille A, Janoueix-Lerosey I, Langsley G, Bornens M, Goud B (1999) Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome. EMBO J 18: 1772-1782
36. Cukierman E, Huber I, Rotman M, Cassel D (1995) The ARF1 GTPase-activating protein: zinc finger motif and Golgi complex localization. Science 270: 1999-2002
37. d'Enfert C, Gensse M, Gaillardin C (1992) Fission yeast and a plant have functional homologues of the Sar1 and Sec12 proteins involved in ER to Golgi traffic in budding yeast EMBO J 11: 4205-4211
38. Donaldson JG (2000) Filling in the GAPs in the ADP-ribosylation factor story. Proc Natl Acad Sci USA 97: 3792-3794
39. Donaldson JG, Jackson CL (2000) Regulators and effectors of the ARF GTPases. Curr Opin Cell Biol 12: 475-482
40. Duman JG, Tyagarajan K, Kolsi MS, Moore HP, Forte JG (1999) Expression of rab11a N124I in gastric parietal cells inhibits stimulatory recruitment of the H+-K+-ATPase. Am J Physiol 277: C361-C372
41. Erickson JW, Cerione RA (2001) Multiple roles for Cdc42 in cell regulation. Curr Opin Cell Biol 13: 153-157
42. Essen LO, Perisic O, Cheung R, Katan M, Williams RL (1996) Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta. Nature 380: 595-602
43. Feng Y, Press B, Wandinger-Ness A (1995) Rab 7: an important regulator of late endocytic membrane traffic. J Cell Biol 131: 1435-1452
44. Fornerod M, Ohno M, Yoshida M, Mattaj IW (1997) CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 90, 1051-1060
45. 2+ levels. J Biol Chem 270: 1337-1341
46. Fu Y, Wu G, Yang Z (2001) Rop GTPase-dependent dynamics of tip-localized F-actin controls tip growth in pollen tubes. J Cell Biol 152: 1019-1032
47. Fu Y, Yang Z (2001) Rop GTPase: a master switch of cell polarity development in plants. Trends Plant Sci 6: 545-547
48. Fu Y, Yang Z (2002) Rop GTPase controls plant cell morphogenesis via a novel form of cortical F-actin. Plant Cell 14: 763-776
49. Gaynor EC, Emr SD (1997) COPI-independent anterograde transport: cargo-selective ER to Golgi protein transport in yeast COPI mutants. J Cell Biol 136: 789-802
50. Geldner N, Friml J, Stierhof YD, Jurgens G, Palme K (2001) Auxin transport inhibitors block PIN1 cycling and vesicle trafficking. Nature 413: 425-428
51. Goud B, Salminen A, Walworth NC, Novick PJ (1988) A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast. Cell 53: 753-768
52. Haasen D, Kohler C, Neuhaus G, Merkle T (1999) Nuclear export of proteins in plants: AtXPO1 is the export receptor for leucine-rich nuclear export signals in Arabidopsis thaliana. Plant J 20: 695-705
53. Haizel T, Merkle T, Pay A, Fejes E, Nagy F (1997) Characterization of proteins that interact with the GTP-bound form of the regulatory GTPase Ran in Arabidopsis. Plant J 11: 93-103
54. Hall A (1998) Rho GTPases and the actin cytoskeleton. Science 279: 509-514
55. Hama H, Tall GG, Horazdovsky BF (1999) Vps9p is a guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport. J Biol Chem 274: 15284-15291
56. Heras B, Drobak BK (2002) PARF-1: an Arabidopsis thaliana FYVE-domain protein displaying a novel eukaryotic domain structure and phosphoinositide affinity. J Exp Bot 53: 565-567
57. Hetzer M, Bilbao-Cortes D, Walther TC, Gruss OJ, Mattaj IW (2000) GTP hydrolysis by Ran is required for nuclear envelope assembly. Mol Cell 5: 1013-1024
58. Honda A, Nogami M, Yokozeki T, Yamazaki M, Nakamura H, Watanabe H, Kawamoto K, Nakayama K, Morris AJ, Frohman MA et al. (1999) Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. Cell 99: 521-532
59. Horazdovsky BF, Busch GR, Emr SD (1994) VPS21 encodes a rab5-like GTP binding protein that is required for the sorting of yeast vacuolar proteins. EMBO J 13: 1297-1309
60. Horiuchi H, Lippé R, McBride HM, Rubino M, Woodman P, Stenmark H, Rybin V, Wilm M, Ashman K, Mann M et al. (1997) A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell 90: 1149-1159
61. Huber LA, de Hoop MJ, Dupree P, Zerial M, Simons K, Dotti C (1993a) Protein transport to the dendritic plasma membrane of cultured neurons is regulated by rab8p. J Cell Biol 123: 47-55
62. Huber LA, Pimplikar S, Patton RG, Virta H, Zerial M, Simons K (1993b) Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane. J Cell Biol 123: 35-45
63. Inaba T, Nagano Y, Nagasaki T, Sasaki Y (2002) Distinct localization of two closely related Ypt3/Rab11 proteins on the trafficking pathway in higher plants. J Biol Chem 277: 9183-9188
64. Iwasaki K, Toyonaga R (2000) The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission. EMBO J 19: 4806-4816
65. Izaurralde E, Jarmolowski A, Beisel C, Mattaj IW, Dreyfuss G, Fischer U (1997) A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export J Cell Biol 137: 27-35
66. Jedd G, Mulholland J, Segev N (1997) Two new Ypt GTPases are required for exit from the yeast trans-Golgi compartment. J Cell Biol 137: 563-580
67. Jensen RB, La Cour T, Albrethsen J, Nielsen M, Skriver K (2001) FYVE zinc-finger proteins in the plant model Arabidopsis thaliana: identification of PtdIns3P-binding residues by comparison of classic and variant FYVE domains. Biochem J 1: 165-173
68. Johnson DI, Pringle JR (1990) Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity. J Cell Biol 111: 143-152
69. Jones MA (2002) The Arabidopsis Rop2 GTPase is a positive regulator of both root hair initiation and tip growth. Plant Cell 14: 777-794
70. Kahn RA, Der CJ, Bokoch GM (1992) The ras superfamily of GTP-binding proteins: guidelines on nomenclature FASEB J 6: 2512-2513
71. Kaibuchi K, Kuroda S, Amano M (1999) Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells. Annu Rev Biochem 68: 459-486
72. Kalab P, Pu RT, Dasso M (1999) The ran GTPase regulates mitotic spindle assembly. Curr Biol 9: 481-484
73. Kang JG, Yun J, Kim DH, Chung KS, Fujioka S, Kim JI, Dae HW, Yoshida S, Takatsuto S, Song PS et al. (2001) Light and brassinosteroid signals are integrated via a dark-induced small G protein in etiolated seedling growth. Cell 105: 625-636
74. Kawasaki T, Henmi K, Ono E, Hatakeyama S, Iwano M, Satoh H, Shimamoto K (1999) The small GTP-binding protein rac is a regulator of cell death in plants. Proc Natl Acad Sci USA 96: 10922-10926
75. Kim SH, Arnold D, Lloyd A, Roux SJ (2001) Antisense expression of an Arabidopsis ran binding protein renders transgenic roots hypersensitive to auxin and alters auxin-induced root growth and development by arresting mitotic progress. Plant Cell 13: 2619-2630
76. Kim WY, Kim CY, Cheong NE, Choi YO, Lee KO, Lee SH, Park JB, Nakano A, Bahk JD, Cho MJ et al. (1999) Characterization of two fungal-elicitor-induced rice cDNAs encoding functional homologues of the rtab-specific GDP-dissociation inhibitor. Planta 210: 143-149
77. Kirchhausen T (2000) Three ways to make a vesicle Nat Rev Mol Cell Biol 1: 187-198
78. Kliebenstein DJ, Lim JE, Landry LG, Last RL (2002) Arabidopsis UVR8 regulates ultraviolet-B signal transduction and tolerance and contains sequence similarity to human regulator of chromatin condensation 1. Plant Physiol 130: 234-243
79. Kost B, Lemichez E, Spielhofer P, Hong Y, Tolias K, Carpenter C, Chua NH (1999) Rac homologues and compartmentalized phosphatidylinositol 4,5-bisphosphate act in a common pathway to regulate polar pollen tube growth. J Cell Biol 145: 317-330
80. Lanzetti L, Rybin V, Malabarba MG, Christoforidis S, Scita G, Zerial M, Di Fiore PP (2000) The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5. Nature 408: 374-377
81. Lazar T, Gotte M, Gallwitz D (1997) Vesicular transport: How many Ypt/Rab-GTPases make a eukaryotic cell? Trends Biochem Sci 22: 468-472
82. Lemichez E, Wu Y, Sanchez JP, Mettouchi A, Mathur J, Chua NH (2001) Inactivation of AtRac1 by abscisic acid is essential for stomatal closure. Genes Dev 15: 1808-1816
83. Lemmon MA, Ferguson KM, Abrams CS (2002) Pleckstrin homology domains and the cytoskeleton. FEBS Lett 513: 71-76
84. Letunic I, Goodstadt L, Dickens NJ, Doerks T, Schultz J, Mott R, Ciccarelli F, Copley RR, Ponting CP, Bork P (2002) Recent improvements to the SMART domain-based sequence annotation resource. Nucleic Acids Res 30: 242-244
85. Li H, Lin Y, Heath RM, Zhu MX, Yang Z (1999) Control of pollen tube tip growth by a Rop GTPase-dependent pathway that leads to tip-localized calcium influx. Plant Cell 11: 1731-1742
86. Li H, Shen JJ, Zheng ZL, Lin Y, Yang Z (2001) The Rop GTPase switch controls multiple developmental processes in Arabidopsis. Plant Physiol 126: 670-684
87. Li H, Wu G, Ware D, Davis KR, Yang Z (1998) Arabidopsis Rho-related GTPases: differential gene expression in pollen and polar localization in fission yeast. Plant Physiol 118: 407-417
88. Lu C, Zainal Z, Tucker GA, Lycett GW (2001) Developmental abnormalities and reduced fruit softening in tomato plants expressing an antisense Rab11 GTPase gene. Plant Cell 13: 1819-1833
89. Lynch MA, Staehelin LA (1992) Domain-specific and cell type-specific localization of two types of cell wall matrix polysaccharides in the clover root tip. J Cell Biol 118: 467-479
90. Machesky LM, Hall A (1997) Role of actin polymerization and adhesion to extracellular matrix in Rac- and Rho-induced cytoskeletal reorganization. J Cell Biol 138: 913-926
91. Martinez O, Antony C, Pehau-Arnaudet G, Berger EG, Salamero J, Goud B (1997) GTP-bound forms of rab6 induce the redistribution of Golgi proteins into the endoplasmic reticulum. Proc Natl Acad Sci USA 94: 1828-1833
92. Mayer U, Büttner G, Jürgens G (1993) Apical-basal formation in the Arabidopsis embyro: studies on the role of the gnom gene. Development 117: 149-162
93. Mayer U, Torrez-Ruiz RA, Berleth T, Misera S, Jürgens G (1991) Mutations affecting body organization in the Arabidopsis embryo. Nature 353: 402-407
94. McElver J, Patton D, Rumbaugh M, Liu C, Yang LJ, Meinke D (2000) The TITAN5 gene of Arabidopsis encodes a protein related to the ADP ribosylation factor family of GTP binding proteins Plant Cell 12: 1379-1392
95. Merkle T, Haizel T, Matsumoto T, Harter K, Dallmann G, Nagy F (1994) Phenotype of the fission yeast cell cycle regulatory mutant pim1-46 is suppressed by a tobacco cDNA encoding a small, Ran-like GTP-binding protein. Plant J 6: 555-565
96. Meyerowitz EM (1999) Plants, animals and the logic of development. Trends Cell Biol 9: M65-M68
97. Meyerowitz EM (2002) Plants compared to animals: the broadest comparative study of development. Science 295: 1482-1485
98. Molendijk AJ, Bischoff F, Rajendrakumar CS, Friml J, Braun M, Gilroy S, Palme K (2001) Arabidopsis thaliana Rop GTPases are localized to tips of root hairs and control polar growth. EMBO J 20: 2779-2788
99. Moore MS (1998) Ran and nuclear transport. J Biol Chem 273: 22857-22860
100. Moore MS, Blobel G (1993) The GTP-binding protein Ran/TC4 is required for protein import into the nucleus. Nature 365: 661-663
101. Moss J, Vaughan M (1998) Molecules in the ARF orbit. J Biol Chem 273: 21431-21434
102. Mukhopadhyay A, Funato K, Stahl PD (1997) Rab7 regulates transport from early to late endocytic compartments in Xenopus oocytes. J Biol Chem 272: 13055-13059
103. Nagano F, Sasaki T, Fukui K, Asakura T, Imazumi K, Takai Y (1998) Molecular cloning and characterization of the noncatalytic subunit of the Rab3 subfamily-specific GTPase-activating protein. J Biol Chem 273: 24781-24785
104. Nagano Y, Okada Y, Narita H, Asaka Y, Sasaki Y (1995) Location of light-repressible, small GTP-binding protein of the YPT/rab family in the growing zone of etiolated pea stems. Proc Natl Acad Sci USA 92: 6314-6318
105. Nuoffer C, Davidson HW, Matteson J, Meinkoth J, Balch WE (1994) A GDP-bound of rab1 inhibits protein export from the endoplasmic reticulum and transport between Golgi compartments. J Cell Biol 125: 225-237
106. Ohba T, Nakamura M, Nishitani H, Nishimoto T (1999) Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran. Science 284: 1356-1358
107. Paris N, Stanley CM, Jones RL, Rogers JC (1996) Plant cells contain two functionally distinct vacuolar compartments. Cell 85: 563-572
108. Pay A, Resch K, Frohnmeyer H, Fejes E, Nagy F, Nick P (2002) Plant RanGAPs are localized at the nuclear envelope in interphase and associated with microtubules in mitotic cells. Plant J 30: 699-709
109. Pereira-Leal JB, Seabra MC (2000) The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily. J Mol Biol 301: 1077-1087
110. Pereira-Leal JB, Seabra MC (2001) Evolution of the Rab family of small GTP-binding proteins. J Mol Biol 313: 889-901
111. Poon PP, Cassel D, Spang A, Rotman M, Pick E, Singer RA, Johnston GC (1999) Retrograde transport from the yeast Golgi is mediated by two ARF GAP proteins with overlapping function. EMBO J 18: 555-564
112. Price A, Seals D, Wickner W, Ungermann C (2000) The docking stage of yeast vacuole fusion requires the transfer of proteins from a cis-SNARE complex to a Rab/Ypt protein. J Cell Biol 148: 1231-1238
113. Randazzo PA, Andrade J, Miura K, Brown MT, Long YQ, Stauffer S, Roller P, Cooper JA (2000) The Arf GTPase-activating protein ASAP1 regulates the actin cytoskeleton. Proc Natl Acad Sci USA 97: 4011-4016
114. Regad F, Bardet C, Tremousaygue D, Moisan A, Lescure B, Axelos M (1993) cDNA cloning and expression of an Arabidopsis GTP-binding protein of the ARF family. FEBS Lett 316: 133-136
115. Ridley A (2000) Rho. In A Hall, ed, GTPases. Oxford University Press, Oxford, pp 89-136
116. Ridley AJ (1995) Intracellular regulation: Rac and Bcr regulate phagocytic phoxes. Currt Biol 5: 710-712
117. Ritzenthaler C, Nebenfuhr A, Movafeghi A, Stussi-Garaud C, Behnia L, Pimpl P, Staehelin LA, Robinson DG (2002) Reevaluation of the effects of brefeldin A on plant cells using tobacco bright yellow 2 cells expressing Golgi-targeted green fluorescent protein and COPI antisera. Plant Cell 14: 237-261
118. Rose A, Meier I (2001) A domain unique to plant RanGAP is responsible for its targeting to the plant nuclear rim. Proc Natl Acad Sci USA 98: 15377-15382
119. Rush MG, Drivas G, D'Eustachio P (1996) The small nuclear GTPase Ran: How much does it run? Bioessays 18: 103-112
120. Salminen A, Novick PJ (1987) A ras-like protein is required for a post-Golgi event in yeast secretion. Cell 49: 527-538
121. Segev N, Mulholland J, Botstein D (1988) The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery. Cell 52: 915-924
122. Settleman J (2001) Rac 'n Rho: the music that shapes a developing embryo. Dev Cell 1: 321-331
123. 2+-dependent electrostatic switch. Neuron 18: 133-142
124. Simons K, Zerial M (1993) Rab proteins and the road maps for intracellular transport. Neuron 11: 789-799
125. Simonsen A, Lippe R, Christoforidis S, Gaullier JM, Brech A, Callaghan J, Toh BH, Murphy C, Zerial M, Stenmark H (1998) EEA1 links PI(3) K function to Rab5 regulation of endosome fusion. Nature 394: 494-498
126. Singer-Krüger B, Stenmark H, Zerial M (1995) Yeast Ypt51p and mammalian Rab5: counterparts with similar function in the early endocytic pathway. J Cell Sci 108: 3509-3521
127. Siniossoglou S, Peak-Chew SY, Pelham HR (2000) Ric1p and Rgp1p form a complex that catalyses nucleotide exchange on Ypt6p. EMBO J 19: 4885-4894
128. Springer S, Spang A, Schekman R (1999) A primer on vesicle budding. Cell 97: 145-148
129. Steinmann T, Geldner N, Grebe M, Mangold S, Jackson CL, Paris S, Galweiler L, Palme K, Jurgens G (1999) Coordinated polar localization of auxin efflux carrier PIN1 by GNOM ARF GEF. Science 286: 316-318
130. Stenmark H, Olkkonen VM (2001) The Rab GTPase family. Genome Biol 2: Reviews 3007.1-3007.7
131. Strom M, Vollmer P, Tan TJ, Gallwitz D (1993) A yeast GTPase-activating protein that interacts specifically with a member of the Ypt/Rab family. Nature 361: 736-739
132. 2+/phospholipid-binding fold. Cell 80: 929-938
133. Swofford DL, Waddell PJ, Huelsenbeck JP, Foster PG, Lewis PO, Rogers JS (2001) Bias in phylogenetic estimation and its relevance to the choice between parsimony and likelihood methods. Syst Biol 50: 525-539
134. Takai Y, Sasaki T, Matozaki T (2001) Small GTP-binding proteins. Physiol Rev 81: 153-208
135. Tamkun JW, Kahn RA, Kissinger M, Brizuela BJ, Rulka C, Scott MP, Kennison JA (1991) The arflike gene encodes an essential GTP-binding protein in Drosophila. Proc Natl Acad Sci USA 88: 3120-3124
136. Thompson JD, Higgins DG, Gibson TJ (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22: 4673-4680
137. Tisdale EJ, Bourne JR, Khosravi-Far R, Der CJ, Balch WE (1992) GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex. J Cell Biol 119: 749-761
138. Trotochaud AE, Hao T, Wu G, Yang Z, Clark SE (1999) The CLAVATA1 receptor-like kinase requires CLAVATA3 for its assembly into a signaling complex that includes KAPP and a Rho-related protein. Plant Cell 11: 393-406
139. Ueda T, Matsuda N, Anai T, Tsukaya H, Uchimiya H, Nakano A (1996) An Arabidopsis gene isolated by a novel method for detecting genetic interaction in yeast encodes the GDP dissociation inhibitor of Ara4 GTPase. Plant Cell 8: 2079-2091
140. Ueda T, Yamaguchi M, Uchimiya H, Nakano A (2001) Ara6, a plant-unique novel type Rab GTPase, functions in the endocytic pathway of Arabidopsis thaliana. EMBO J 20: 4730-4741
141. Ueda T, Yoshizumi T, Anai T, Matsui M, Uchimiya H, Nakano A (1998) AtGDI2, a novel Arabidopsis gene encoding a Rab GDP dissociation inhibitor. Gene 206: 137-143
142. Ullrich O, Reinsch S, Urbe S, Zerial M, Parton RG (1996) Rab11 regulates recycling through the pericentriolar recycling endosome. J Cell Biol 135: 913-924
143. Valster AH, Hepler PK, Chernoff J (2000) Plant GTPases: the Rhos in bloom. Trends Cell Biol 10: 141-146
144. Vitale A, Raikhel NV (1999) What do proteins need to reach different vacuoles? Trends Plant Sci 4: 149-155
145. Vollmer P, Gallwitz D (1995) High expression cloning, purification, and assay of Ypt-GTPase-activating proteins. Methods Enzymol 257: 118-128
146. Vollmer P, Will E, Scheglmann D, Strom M, Gallwitz D (1999) Primary structure and biochemical characterization of yeast GTPase-activating proteins with substrate preference for the transport GTPase Ypt7p. Eur J Biochem 260: 284-290
147. Wada M, Nakanishi H, Satoh A, Hirano H, Obaishi H, Matsuura Y, Takai Y (1997) Isolation and characterization of a GDP/GTP exchange protein specific for the Rab3 subfamily small G proteins. J Biol Chem 272: 3875-3878
148. Walch-Solimena C, Collins RN, Novick PJ (1997) Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesicles. J Cell Biol 137: 1495-1509
149. Walch-Solimena C, Novick P (1999) The yeast phosphatidylinositol-4-OH kinase pik1 regulates secretion at the Golgi. Nat Cell Biol 1: 523-525
150. White J, Johannes L, Mallard F, Girod A, Grill S, Reinsch S, Keller P, Tzschaschel B, Echard A, Goud B et al. (1999) Rab6 coordinates a novel Golgi to ER retrograde transport pathway in live cells. J Cell Biol 147: 743-760
151. Wieland F, Harter C (1999) Mechanisms of vesicle formation: insights from the COP system. Curr Opin Cell Biol 11: 440-446
152. Wiese C, Wilde A, Moore MS, Adam SA, Merdes A, Zheng Y (2001) Role of importin-beta in coupling Ran to downstream targets in microtubule assembly. Science 291: 653-656
153. Wigge P, McMahon HT (1998) The amphiphysin family of proteins and their role in endocytosis at the synapse. Trends Neurosci 21: 339-344
154. Wilde A, Zheng Y (1999) Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran. Science 284: 1359-1362
155. Winge P, Brembu T, Bones AM (1997) Cloning and characterization of rac-like cDNAs from Arabidopsis thaliana. Plant Mol Biol 35: 483-495
156. Winge P, Brembu T, Kristensen R, Bones AM (2000) Genetic structure and evolution of RAC-GTPases in Arabidopsis thaliana. Genetics 156: 1959-1971
157. Wittmann T, Waterman-Storer CM (2001) Cell motility: Can Rho GTPases and microtubules point the way? J Cell Sci 114: 3795-3803
158. Wu G, Gu Y, Li S, Yang Z (2001) A genome-wide analysis of Arabidopsis Rop-interactive CRIB motif-containing proteins that act as Rop GTPase targets. Plant Cell 13: 2841-2856
159. Wu G, Li H, Yang Z (2000) Arabidopsis RopGAPs are a novel family of rho GTPase-activating proteins that require the Cdc42/Rac-interactive binding motif for rop-specific GTPase stimulation. Plant Physiol 124: 1625-1636
160. Yamochi W, Tanaka K, Nonaka H, Maeda A, Musha T, Takai Y (1994) Growth site localization of Rho1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae. J Cell Biol 125: 1077-1093
161. Yang Z (2002) Small GTPases: versatile signaling switches in plants. Plant Cell 14: S375-S388
162. Zarsky V, Cvrckova F, Bischoff F, Palme K (1997) At-GDI1 from Arabidopsis thaliana encodes a rab-specific GDP dissociation inhibitor that complements the sec19 mutation of Saccharomyces cerevisiae. FEBS Lett 403: 303-308
163. Zerial M, McBride H (2001) Rab proteins as membrane organizers. Nat Rev Mol Cell Biol 2: 107-117
164. Zhang C, Clarke PR (2000) Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts. Science 288: 1429-1432
165. Zheng ZL, Nafisi M, Tam A, Li H, Crowell DN, Chary SN, Schroeder JI, Shen J, Yang Z (2002) The plasma membrane-associated ROP10 small GTPase is a specific negative regulator of abscisic acid responses in Arabidopsis. Plant Cell 14: 2787-2797
166. Zheng ZL, Yang Z (2000a) The Rop GTPase: an emerging signaling switch in plants. Plant Mol Biol 44: 1-9
167. Zheng ZL, Yang Z (2000b) The Rop GTPase switch turns on polar growth in pollen. Trends Plant Sci 5: 298-303