Pacing in heart failure: The benefit of resynchronization

Cleveland Clinic Journal of Medicine

Volumn 70, Issue 10, 2003, Pages 841-865

  Khaykin, Yaariv ^a   Saad, Eduardo B ^a   Wilkoff, Bruce L ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ARTIFICIAL HEART PACEMAKER; ATRIOVENTRICULAR CONDUCTION; DISEASE SEVERITY; EXERCISE; HEART EJECTION FRACTION; HEART FAILURE; HEART FUNCTION; HEART HEMODYNAMICS; HEART LEFT VENTRICLE; HEART MUSCLE CONDUCTION DISTURBANCE; HEART PACING; HEART RIGHT VENTRICLE; HOSPITALIZATION; HUMAN; MEDICAL DECISION MAKING; PATIENT SELECTION; QUALITY OF LIFE; SURGICAL TECHNIQUE; TREATMENT OUTCOME; WALKING;

EID: 0142248755     PISSN: 08911150     EISSN: None     Source Type: Journal    
DOI: 10.3949/ccjm.70.10.841     Document Type: Article

References (124)

1. Heart Failure Society of America (HFSA) practice guidelines. HFSA guidelines for management of patients with heart failure caused by left ventricular systolic dysfunction - pharmacological approaches. J Card Fail 1999; 5:357-382.
2. The CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N Engl J Med 1987; 316:1429-1435.
3. The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 1991; 325:293-302.
4. The Digitalis Investigation Group. The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med 1997; 336:525-533.
5. Bristow MR. Beta-adrenergic receptor blockade in chronic heart failure. Circulation 2000; 101:558-569.
6. Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluatiorn Study Investigators. N Engl J Med 1999; 341:709-717.
7. Buxton AE, Lee KL, Fisher JD, et al. A randomized study of the prevention of sudden death in patients with coronary artery disease. Multicenter Unsustained Tachycardia Trial Investigators. N Engl J Med 1999; 341:1882-1890.
8. Moss AJ, Zareba W, Hall WJ, et al. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med 2002; 346:877-883.
9. Rose EA, Gelijns AC, Moskowitz AJ, et al. Long-term mechanical left ventricular assistance for end-stage heart failure. N Engl J Med 2001; 345:1435-1443.
10. Leclercq C, Kass DA. Retiming the failing heart: principles and current clinical status of cardiac resynchronization. J Am Coll Cardiol 2002; 39:194-201.
11. Wiggers CJ. Are ventricular conduction changes important in the dynamics of left ventricular contraction? Am J Physiol 1926; 74:12-30.
12. Harrison TR. Some unanswered questions concerning enlargement and failure of heart. Am Heart J 1965; 69:100-115.
13. Herman MV, Heinle RA, Klein MD, Gorlin R. Localized disorders in myocardial contraction. Asynergy and its role in congestive heart failure. N Engl J Med 1967; 277:222-232.
14. Bramlet DA, Morris KG, Coleman RE, Albert DCobb FR. Effect of rate-dependent left bundle branch block on global and regional left ventricular function. Circulation 1983; 67:1059-1065.
15. Prinzen FW, Augustijn CH, Arts T, Allessie MA, Reneman RS. Redistribution of myocardial fiber strain and blood flow by asynchronous activation. Am J Physiol 1990; 259:H300-H308.
16. Prinzen FW, Hunter WC, Wyman BT, McVeigh ER. Mapping of regional myocardial strain and work during ventricular pacing: experimental study using magnetic resonance imaging tagging. J Am Coll Cardiol 1999; 33:1735-1742.
17. Wyman BT, Hunter WC, Prinzen FW, McVeigh ER. Mapping propagation of mechanical activation in the paced heart with MRI tagging. Am J Physiol 1999; 276:H881-H891.
18. Stevenson WG, Stevenson LW, Middlekauff HR, et al. Improving survival for patients with advanced heart failure: a study of 737 consecutive patients. J Am Coll Cardiol 1995; 26:1417-1423.
19. Zhou Q, Henein M, Coats A, Gibson D. Different effects of abnormal activation and myocardial disease on left ventricular ejection and filling times. Heart 2000; 84:272-276.
20. Ansalone G, Giannantoni P, Ricci R, et al. Doppler myocardial imaging in patients with heart failure receiving biventricular pacing treatment. Am Heart J 2001; 142:881-896.
21. Nelson GS, Fetics BJ, Murabayashi T, Rochitte CE, Talbot M, Berger RD. Cardiac variability imaging enables detection of pacing improved contractile coordination in patients with dilated cardiomyopathy and left bundle-branch block [abstract]. Circulation 2000; 120:539.
22. Yu CM, Chau E, Sanderson JE, et al. Tissue Doppler echocardiographic evidence of reverse remodeling and improved synchronicity by simultaneously delaying regional contraction after biventricular pacing therapy in heart failure. Circulation 2002; 105:438-445.
23. Breithardt OA, Stellbrink C, Kramer AP, et al. Echocardiographic quantification of left ventricular asynchrony predicts an acute hemodynamic benefit of cardiac resynchronization therapy. J Am Coll Cardiol 2002; 40:536-545.
24. Kawaguchi M, Murabayashi T, Fetics BJ, et al. Quantitation of basal dyssynchrony and acute resynchronization from left or biventricular pacing by novel echo-contrast variability imaging. J Am Coll Cardiol 2002; 39:2052-2058.
25. Kerwin WF, Botvinick EH, O'Connell JW, et al. Ventricular contraction abnormalities in dilated cardiomyopathy: effect of biventricular pacing to correct interventricular dyssynchrony. J Am Coll Cardiol 2000; 35:1221-1227.
26. Nelson GS, Curry CW, Wyman BT, et al. Predictors of systolic augmentation from left ventricular preexcitation in patients with dilated cardiomyopathy and intraventricular conduction delay. Circulation 2000; 101:2703-2709.
27. Curry CW, Nelson GS, Wyman BT et al. Mechanical dyssynchrony in dilated cardiomyopathy with intraventricular conduction delay as depicted by 3D tagged magnetic resonance imaging. Circulation 2000; 101:E2.
28. Park RC, Little WC, O'Rourke RA. Effect of alteration of left ventricular activation sequence on the left ventricular end-systolic pressure-volume relation in closed-chest dogs. Circ Res 1985; 57:706-717.
29. Littmann L, Symanski JD. Hemodynamic implications of left bundle branch block. J Electrocardiol 2000; 33(suppl):115-121.
30. Grines CL, Bashore TM, Boudoulas H, et al. Functional abnormalities in isolated left bundle branch block. The effect of interventricular asynchrony. Circulation 1989; 79:845-853.
31. Sarubbi B, Ducceschi V, Santangelo L, Iacono A. Arrhythmias in patients with mechanical ventricular dysfunction and myocardial stretch: role of mechano-electric feedback. Can J Cardiol 1998; 14:245-252.
32. ter Keurs HE, Zhang YM, Davidoff AW, et al. Damage induced arrhythmias: mechanisms and implications. Can J Physiol Pharmacol 2001; 79:73-81.
33. Heyndrickx GR, Vantrimpont PJ, Rousseau MF, Pouleur H. Effects of asynchrony on myocardial relaxation at rest and during exercise in conscious dogs. Am J Physiol 1988; 254:H817-822.
34. Ariel Y, Gaasch WH, Bogen DK, McMahon TA. Load-dependent relaxation with late systolic volume steps: servo-pump studies in the intact canine heart. Circulation 1987; 75:1287-1294.
35. Brecker SJ, Xiao HB, Sparrow J, Gibson DG. Effects of dual-chamber pacing with short atrioventricular delay in dilated cardiomyopathy. Lancet 1992; 340:1308-1312.
36. David D, Michelson EL, Naito M, et al. Diastolic "locking" of the mitral valve: the importance of atrial systole and intraventricular volume. Circulation 1983; 67:640-645.
37. Larcos G, Gibbons RJ, Brown ML. Diagnostic accuracy of exercise thallium-201 single-photon emission computed tomography in patients with left bundle branch block. Am J Cardiol 1991; 68:756-760.
38. Caner B, Rezaghi C, Uysal U, et al. Dobutamine thallium-201 myocardial SPECT in patients with left bundle branch block and normal coronary arteries. J Nucl Med 1997; 38:424-427.
39. Tighe DA, Hutchinson HG, Park CH, et al. False-positive reversible perfusion defect during dobutamine-thallium imaging in left bundle branch block. J Nucl Med 1994, 35:1989-1991.
40. Amitzur G, Manor D, Pressman A, et al. Modulation of the arterial coronary blood flow by asynchronous activation with ventricular pacing. Pacing Clin Electrophysiol 1995; 18:697-710.
41. Dresing TJ, Natale A. Congestive heart failure treatment: the pacing approach. Heart Fail Rev 2001; 6:15-25.
42. Hochleitner M, Hortnagl H, Ng CK, Gschnitzer F, Zechmann W. Usefulness of physiologic dual-chamber pacing in drug-resistant idiopathic dilated cardiomyopathy. Am J Cardiol 1990; 66:198-202.
43. Auricchio A, Sommariva L, Salo RW, Scafuri A, Chiariello L. Improvement of cardiac function in patients with severe congestive heart failure and coronary artery disease by dual chamber pacing with shortened AV delay. Pacing Clin Electrophysiol 1993; 16:2034-2043.
44. Linde C, Gadler F, Edner M, et al. Results of atrioventricular synchronous pacing with optimized delay in patients with severe congestive heart failure. Am J Cardiol 1995; 75:919-923.
45. Auricchio A, Stellbrink C, Block M, et al. Effect of pacing chamber and atrioventricular delay on acute systolic function of paced patients with congestive heart failure. The Pacing Therapies for Congestive Heart Failure Study Group. The Guidant Congestive Heart Failure Research Group. Circulation 1999; 99:2993-3001.
46. Kass DA, Chen CH, Curry C, et al. Improved left ventricular mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay. Circulation 1999; 99:1567-1573.
47. Leon AR, Greenberg JM, Kanuru N, et al. Cardiac resynchronization in patients with congestive heart failure and chronic atrial fibrillation: effect of upgrading to biventricular pacing after chronic right ventricular pacing. J Am Coll Cardiol 2002; 39:1258-1263.
48. Porciani MC, Sabini A, Colella A, et al. Interatrial delay does not affect clinical outcomes of cardiac resynchronization therapy [abstract]. PACE 2002; 24:561.
49. Di Pede F, Gasparini G, Raviele A, et al. Effect of atrial stimulation site on the contractile function of heart failure patients with DDD biventricular pacing [abstract). PACE 2002; 24:670.
50. Tantengco MV, Thomas RL, Karpawich PP. Left ventricular dysfunction after long-term right ventricular apical pacing in the young. J Am Coll Cardiol 2001; 37:2093-2100.
51. Victor F, Leclercq C, Mabo P et al. Optimal right ventricular pacing site in chronically implanted patients: a prospective randomized crossover comparison of apical and outflow tract pacing. J Am Coll Cardiol 1999; 33:311-316.
52. Thackray SD, Witte KK, Nikitin NP, Cleland JG. The prevalence of heart failure in the permanently paced population and the utility of BNP as a screening tool [abstract]. J Am Coll Cardiol 2002; 39:160A.
53. Pavia SV, Perez-Lugones A, Lam C, et al. Symptomatic deterioration post dual chamber cardioverter-defibrillator implantation: a retrospective, observational study. J Am Coll Cardiol 2001; 37:89A-90A.
54. Saad EB, Marrouche NF, Martin DO, et al. Frequency and associations of symptomatic deterioration after dual-chamber defibrillator implantation in patients with ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 2002; 90:79-82.
55. Wilkoff BL, Cook JR, Epstein AE, et al. Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator: the Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial. JAMA 2002; 288:3115-3123.
56. Saxon LA, Kerwin WF, Cahalan MK, et al. Acute effects of intraoperative multisite ventricular pacing on left ventricular function and activation/contraction sequence in patients with depressed ventricular function. J Cardiovasc Electrophysiol 1998; 9:13-21.
57. Etienne Y, Mansourati J, Touiza A, et al. Evaluation of left ventricular function and mitral regurgitation during left ventricular-based pacing in patients with heart failure. Eur J Heart Fail 2001; 3:441-447.
58. Kim WY, Sogaard P, Mortensen PT, et al. Three dimensional echocardiography documents haemodynamic improvement by biventricular pacing in patients with severe heart failure. Heart 2001; 85:514-520.
59. Daubert JC, Ritter P, Le Breton H, et al. Permanent left ventricular pacing with transvenous leads inserted into the coronary veins. Pacing Clin Electrophysiol 1998; 21:239-245.
60. Butter C, Auricchio A, Stellbrink C, et al. Should stimulation site be tailored in the individual heart failure patient? Am J Cardiol 2000; 86:K144-K151.
61. Pappone C, Rosanio S, Oreto G, et al. Cardiac pacing in heart failure patients with left bundle branch block: impact of pacing site for optimizing left ventricular resynchronization. Ital Heart J 2000; 1:464-469.
62. Butter C, Auricchio A, Stellbrink C, et al. Effect of resynchronization therapy stimulation site on the systolic function of heart failure patients. Circulation 2001; 104:3026-3029.
63. Ricci R, Ansalone G, Tosacano S, et al. Cardiac resynchronization: materials, technique, and results. The InSync Italian Registry. Eur Heart J 2000; 2:J6-15.
64. Alonso C, Leclercq C, d'Allonnes FR, et al. Six year experience of transvenous left ventricular lead implantation for permanent biventricular pacing in patients with advanced heart failure: technical aspects. Heart 2001; 86:405-410.
65. Cazeau S, Leclercq C, Lavergne T, et al. Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay. N Engl J Med 2001; 344:873-880.
66. Gurley J, Lamba S, Moulton K, et al. Does the availability of left-heart lead and delivery system options matter for cardiac resynchronization therapy? [abstract]. PACE 2002; 24:597.
67. Jais P, Takahashi A, Garrigue S, et al. Mid-term follow-up of endocardial biventricular pacing. Pacing Clin Electrophysiol 2000; 23:1744-1747.
68. Garrigue S, Jais P, Espil G, et al. Comparison of chronic biventricular pacing between epicardial and endocardial left ventricular stimulation using Doppler tissue imaging in patients with heart failure. Am J Cardiol 2001; 88:858-862.
69. Gras D, Mabo P, Tang T, et al. Multisite pacing as a supplemental treatment of congestive heart failure: preliminary results of the Medtronic Inc. InSync Study. Pacing Clin Electrophysiol 1998; 21:2249-2255.
70. Auricchio A, Stellbrink C, Sack S, et al. The Pacing Therapies for Congestive Heart Failure (PATH-CHF) study: rationale, design, and endpoints of a prospective randomized multicenter study. Am J Cardiol 1999; 83:130D-135D.
71. Auricchio A, Stellbrink C, Sack S, et al. Long-term clinical effect of hemodynamically optimized cardiac resynchronization therapy in patients with heart failure and ventricular conduction delay. J Am Coll Cardiol 2002; 39:2026-2033.
72. Linde C, Leclercq C, Rex S, et al. Long-term benefits of biventricular pacing in congestive heart failure: results from the MUltisite STimulation in cardiomyopathy (MUSTIC) study. J Am Coll Cardiol 2002; 40:111-118.
73. Leclercq C, Linde C, Cazeau S, et al. Sustained clinical efficacy of biventricular pacing in patients with advanced heart failure and stable sinus rhythm. 2 year follow-up from the MUSTIC study [abstract]. PACE (II) 2002; 24:601.
74. Abraham WT, Fisher WG, Smith AL, et al. Cardiac resynchronization in chronic heart failure. N Engl J Med 2002; 346:1845-1853.
75. Abraham WT, Fisher W, Smith A, et al. Long-term improvement in functional status, quality of life and exercise capacity with cardiac resynchronization therapy: the MIRACLE trial experience [abstract]. J Am Coll Cardiol 2002; 39:159A.
76. St John Sutton M, Kokovic D, Plappert T, et al. Cardiac resynchronization therapy results in reverse remodeling in both ischemic and non-ischemic heart failure patients. PACE 2002; 24:716.
77. Conti J, Curtis A, Aranda J Jr, Abraham WT, Petersen-Stejskal S, Paulsen D. Are there differences in gender response to cardiac resynchronization therapy? Analysis of the MIRACLE trial [abstract]. PACE 2002; 24:694.
78. Lupi G, Brignole M, Oddone D, et al. Effects of left ventricular pacing on cardiac performance and on quality of life in patients with drug refractory heart failure. Am J Cardiol 2000; 86:1267-1270.
79. Braunschweig F, Linde C, Gadler F, Ryden L. Reduction of hospital days by biventricular pacing. Eur J Heart Fail 2000; 2:399-406.
80. Foster AH, Gold MR, McLaughlin JS. Acute hemodynamic effects of atrio-biventricular pacing in humans. Ann Thorac Surg 1995; 59:294-300.
81. Leclercq C, Cazeau S, Le Breton H, et al. Acute hemodynamic effects of biventricular DDD pacing in patients with end-stage heart failure. J Am Coll Cardiol 1998; 32:1825-1831.
82. Blanc JJ, Etienne Y, Gilard M, et al. Evaluation of different ventricular pacing sites in patients with severe heart failure: results of an acute hemodynamic study. Circulation 1997; 96:3273-3277.
83. Auricchio A, Ding J, Spinelli JC, et al. Cardiac resynchronization therapy restores optimal atrioventricular mechanical timing in heart failure patients with ventricular conduction delay. J Am Coll Cardiol 2002; 39:1163-1169.
84. Nelson GS, Berger RD, Fetics BJ, et al. Left ventricular or biventricular pacing improves cardiac function at diminished energy cost in patients with dilated cardiomyopathy and left bundle-branch block. Circulation 2000; 102:3053-3059.
85. Mansourati J, Etienne Y, Gilard M, et al. Left ventricular-based pacing in patients with chronic heart failure: comparison of acute hemodynamic benefits according to underlying heart disease. Eur J Heart Fail 2000; 2:195-199.
86. Packer M. New concepts in the pathophysiology of heart failure: beneficial and deleterious interaction of endogenous haemodynamic and neurohormonal mechanisms. J Intern Med 1996; 239:327-333.
87. Saxon LA, Boehmer JP, Hummel J, et al. Biventricular pacing in patients with congestive heart failure: two prospective randomized trials. The VIGOR CHF and VENTAK CHF Investigators. Am J Cardiol 1999; 83:120D-123D.
88. Spaziani D, Pagani M, del Rosso G, De Servi S, Grassi G, Mancia G. Reduction of norepinephrine levels with biventricular pacing but recurrence of arrhythmic events in patients with biventricular ICD and cardiomyopathy [abstract]. J Am Coll Cardiol 2002; 39:78A.
89. Hamdan MH, Zagrodzky JD, Joglar JA, et al. Biventricular pacing decreases sympathetic activity compared with right ventricular pacing in patients with depressed ejection fraction. Circulation 2000; 102:1027-1032.
90. Hamdan MH, Barbera S, Kowal RC, et al. Effects of resynchronization therapy on sympathetic activity in patients with depressed ejection fraction and intraventricular conduction delay due to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 2002; 89:1047-1051.
91. Alonso C, Leclercq C, Mabo P, Lavergne T, Daubert JC. Atriobiventricular pacing improves heart rate variability in patients with severe heart failure. Eur J Heart Fail 2001; 3:24.
92. Sinha A, Zarse M, Markus KU, et al. Effects of cardiac resynchronization therapy on heart rate variability in patients with heart failure and left bundle branch block [abstract]. PACE 2002; 24:624.
93. Saxon LA, De Marco T, Schafer J, Chatterjee K, Kumar UN, Foster E, for the VIGOR Congestive Heart Failure Investigators. Effects of long-term biventricular stimulation for resynchronization on echocardiographic measures of remodeling. Circulation 2002; 105:1304-1310.
94. Kuhlkamp V. Initial experience with an implantable cardioverter-defibrillator incorporating cardiac resynchronization therapy. J Am Coll Cardiol 2002; 39:790-797.
95. Stellbrink C, Breithardt OA, Franke A, et al. Impact of cardiac resynchronization therapy using hemodynamically optimized pacing on left ventricular remodeling in patients with congestive heart failure and ventricular conduction disturbances. J Am Coll Cardiol, 2001; 38:1957-1965.
96. Yu CM, Nicholls GM, Sanderson JE, et al. Echocardiographic and neurohormonal predictors of left ventricular reverse remodeling after biventricular pacing for heart failure [abstract]. J Am Coll Cardiol 2002; 39:96A.
97. St. John Sutton M, Plappert T, Abraham WT, et al. Echocardiographic predictors of functional class changes during cardiac resynchronization therapy: results from the MIRACLE trial [abstract]. J Am Coll Cardiol 2002; 39:107A.
98. Greenberg JM, Ransom S, DeLurgio DB, Mera FV, Leon AR. Left ventricular remodeling during cardiac resynchronization therapy: effect on ventricular dimension and stimulation threshold chronically after biventricular pacing [abstract]. J Am Coll Cardiol 2002; 5:107A.
99. Walker S, Levy TM, Rex S, et al. Usefulness of suppression of ventricular arrhythmia by biventricular pacing in severe congestive cardiac failure. Am J Cardiol 2000; 86:231-233.
100. Higgins SL, Yong P, Sheck D, et al. Biventricular pacing diminishes the need for implantable cardioverter defibrillator therapy. Ventak CHF Investigators. J Am Coll Cardiol 2000; 36:824-827.
101. Garrigue S, Barold SS, Hocini M, et al. Treatment of drug refractory ventricular tachycardia by biventricular pacing. Pacing Clin Electrophysiol 2000; 23:1700-1702.
102. Zagrodzky JD, Ramaswamy K, Page RL, et al. Biventricular pacing decreases the inducibility of ventricular tachycardia in patients with ischemic cardiomyopathy. Am J Cardiol 2001; 87:1208-1210.
103. Liem L, Leon A, Young JB. Effectiveness of bi-ventricular antitachycardia pacing in CHF patients receiving cardiac resynchronization therapy [abstract]. PACE 2002; 24:647.
104. Krater L, Lamp B, Heintze J, et al. Influence of antitachy pacing location on the efficacy of ventricular tachycardia termination [abstract]. J Am Coll Cardiol 2002; 39:124A.
105. Kumar V, Higgins SL, Putz EJ, et al. Effect of chronic resynchronization therapy on ICD therapies [abstract]. PACE 2002; 24:558.
106. de Teresa E, Alzueta J, Jimenez-Navarro M. Profiling risk from arrhythmic or hemodynamic death. Am J Cardiol 2000; 86:K126-K132.
107. Young JB, Abraham WT, Liem L, Leon AR. Cardiac resynchronization therapy benefits patients with ICD indications - results of the InSync ICD trial [abstract]. PACE 2002; 24:694.
108. St. John Sutton M, Plappert T, Young J, Hilpisch KE, Hill MRS. Cardiac resynchronization therapy results in improvement in echocardiographic parameters in heart failure patients with an indication for an ICD: evidence from the InSync trial [abstract). PACE 2002; 24:648.
109. Abraham WT, Young J, Kocovic D, et al. Cardiac resynchronization therapy benefits patients - combined results of the MIRACLE and MIRACLE ICD trials [abstract]. PACE 2002; 24:558.
110. Daoud E, Hummel J, Higgins S, et al. Does ventricular resynchronization therapy influence total survival? [abstract]. PACE 2001; 24:539.
111. Al-Khatib SM, Hassleblad V. Does cardiac resynchronization therapy improve survival of patients with symptomatic congestive heart failure? [abstract]. PACE 2002; 24:669.
112. Leclercq C, Victor F, Alonso C, et al. Comparative effects of permanent biventricular pacing for refractory heart failure in patients with stable sinus rhythm or chronic atrial fibrillation. Am J Cardiol 2000; 85:1154-1156.
113. Daubert JC, Linde C, Cazeau S, Kappenberger L, Sutton R, Bailleul C. Clinical effects of biventricular pacing in patients with severe heart failure and chronic atrial fibrillation: results from the Multisite Stimulation in Cardiomyopathy (MUSTIC) study group II [abstract]. Circulation 2000; 102(suppl 2):II-693.
114. Gabor JY, Hanly PJ, Khaykin Y, et al. The effect of biventricular pacing for heart failure on sleep: a possible further mechanism of benefit [abstract]. Can J Cardiol 2002; 18:186B.
115. Bristow MR, Feldman AM, Saxon LA. Heart failure management using implantable devices for ventricular resynchronization: Comparison of Medical Therapy, Pacing, and Defibrillation in Chronic Heart Failure (COMPANION) trial. COMPANION Steering Committee and COMPANION Clinical Investigators. J Card Fail 2000; 6:276-285.
116. Leon AR, Brozena S, Liang CS, et al. Effect of cardiac resynchronization therapy with sequential biventricular pacing on Doppler-derived left ventricular stroke volume, functional status and exercise capacity in patients with ventricular dysfunction and conduction delay: the US InSync III trial [abstract]. PACE 2002; 24:558.
117. Kanuru NK, DeLurgio DB, Ransom S, et al. Right ventricular septal versus right ventricular apical pacing in biventricular pacing systems does not affect patient functional improvement [abstract]. PACE 2002; 24:648.
118. Cleland JG, Daubert JC, Erdmann E, et al. The CARE-HF study (CArdiac REsynchronisation in Heart Failure study): rationale, design and end-points. Eur J Heart Fail 2001; 3:481-489.
119. Aranda JMJ, Curtis AB, Conti JB, Peterson-Stejskal S. Do heart failure patients with right bundle branch block benefit from cardiac resynchronization therapy? Analysis of the MIRACLE study [abstract]. J Am Coll Cardiol 2002; 39:96A.
120. Auricchio A, Geller C, Reek S, Goette A, Klein HU. Delayed electrical activation of the left septum and lateral wall in left bundle branch block: insight from 3-D electroanatomical mapping [abstract]. J Am Coll Cardiol 2002; 39:96A.
121. Lambiase PD, Rinaldi A, Hauck J, et al. Do areas of slow activation limit the benefit of biventricular pacing? A non-contact left ventricular endocardial mapping study [abstract]. PACE 2002; 24:579.
122. Schreieck J, Zrenner B, Kolb C, Ndrepepa G, Schmitt C. Inappropriate shock delivery due to ventricular double detection with a biventricular pacing implantable cardioverter defibrillator. Pacing Clin Electrophysiol 2001; 24:1154-1157.
123. Pappone C, Vicedomini G, Salvati A, et al. Electrical modulation of cardiac contractility: clinical aspects in congestive heart failure. Heart Fail Rev 2001; 6:55-60.
124. Sabbah HN, Haddad W, Mika Y, et al. Cardiac contractility modulation with the impulse dynamics signal: studies in dogs with chronic heart failure. Heart Fail Rev 2001; 6:45-53.