A framework for the present and future development of experimental models of female sexual dysfunction

International Journal of Impotence Research

Volumn 15, Issue SUPPL. 5, 2003, Pages

  Hale, T M ^a   Heaton, J P W ^a   Adams, M A ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Animal models; Behavioral models; Female sexual dysfunction; Pharmacological models; Physiological models

Indexed keywords

ANIMAL MODEL; BLOOD FLOW; CLITORIS; CONFERENCE PAPER; EXPERIMENTAL MODEL; FEMALE SEXUAL DYSFUNCTION; HISTOLOGY; NONHUMAN; ORGASM; PAIN; PRIORITY JOURNAL; RAT; SEXUAL AROUSAL; SEXUAL BEHAVIOR; SMOOTH MUSCLE; VAGINA;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; SEXUAL BEHAVIOR, ANIMAL; SEXUAL DYSFUNCTION, PHYSIOLOGICAL;

EID: 0142246424     PISSN: 09559930     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijir.3901076     Document Type: Conference Paper

References (43)

1. Rosen RC. Prevalence and risk factors of sexual dysfunction in men and women. Curr Psychiatry Rep 2000; 2: 189-195.
2. Berman JR et al. Anatomy and physiology of female sexual function and dysfunction: classification, evaluation and treatment options. Eur Urol 2000; 38: 20-29.
3. Meston CM et al. The neurobiology of sexual function. Arch Gen Psychiatry 2000; 57: 1012-1030.
4. Beharry RK et al. Evidence for centrally initiated genital vasocongestive engorgement in the female rat: findings from a new model of female sexual arousal response. Int J Impot Res 2003; 15: 122-128.
5. Cellek S et al. Nitrergic neurotransmission mediates the non-adrenergic non-cholinergic responses in the clitoral corpus cavernosum of the rabbit. Br J Pharmacol 1998; 125: 1627-1629.
6. Park JK et al. Nitric oxide-cyclic GMP signaling pathway in the regulation of rabbit clitoral cavernosum tone. Exp Biol Med (Maywood) 2002; 227: 1022-1030.
7. Levin RJ. VIP, vagina, clitoral and periurethral glans - an update on human female genital arousal. Exp Clin Endocrinol 1991; 98: 61-69.
8. Palle C et al. Vasoactive intestinal polypeptide and human vaginal blood flow: comparison between transvaginal and intravenous administration. Clin Exp Pharmacol Physiol 1990; 17: 61-68.
9. Hauser-Kronberger C et al. Peptidergic innervation of the human clitoris. Peptides 1999; 20: 539-543.
10. Andersson PO et al. Haemodynamics of pelvic nerve induced penile erection in the dog: possible mediation by vasoactive intestinal polypeptide. J Physiol 1984; 350: 209-224.
11. Andersson PO et al. Vasoactive intestinal polypeptide in relation to penile erection in the cat evoked by pelvic and hypogastric nerve stimulation. J Urol 1987; 138: 419-422.
12. Heaton JP et al. The characterization of a bio-assay of erectile function in a rat model. J Urol 1991; 145: 1099-1102.
13. Paredes RG et al. What do female rats like about sex? Paced mating. Behav Brain Res 1999; 105: 117-127.
14. Hamburger B et al. Apomorphine: facilitation of sexual behaviour in female rats. Eur J Pharmacol 1975; 32: 357-360.
15. La V et al. Recovery of mating behavior in the female rat following VMH lesions. Physiol Behav 1975; 14: 59-63.
16. Nance DM et al. Examination of some factors that control the effects of septal lesions on lordosis behavior. Pharmacol Biochem Behav 1977; 6: 227-234.
17. Giuliano F et al. Vaginal physiological changes in a model of sexual arousal in anesthetized rats. Am J Physiol Regul Integr Comp Physiol 2001; 281: R140-R149.
18. Park K et al. Vasculogenic female sexual dysfunction: the hemodynamic basis for vaginal engorgement insufficiency and clitoral erectile insufficiency. Int J Impot Res 1997; 9: 27-37.
19. Kendrick KM et al. The role of oxytocin release in the mediobasal hypothalamus of the sheep in relation to female sexual receptivity. J Neuroendocrinol 1993; 5: 13-21.
20. Meisel RL et al. A microdialysis study of ventral striatal dopamine during sexual behavior in female Syrian hamsters. Behav Brain Res 1993; 55: 151-157.
21. Richmond G et al. Ventromedial hypothalamic lesions and cholinergic control of female sexual behavior. Physiol Behav 1988; 42: 179-182.
22. Mani SK et al. Nitric oxide mediates sexual behavior in female rats. Proc Natl Acad Sci USA 1994; 91: 6468-6472.
23. Pedersen CA et al. Oxytocin maintains as well as initiates female sexual behavior: effects of a highly selective oxytocin antagonist. Horm Behav 2002; 41: 170-177.
24. Sodersten P et al. Effects of oestradiol and progesterone on the induction and duration of sexual receptivity in cyclic female rats. J Endocrinol 1977; 74: 477-485.
25. Foreman MM et al. Role of hypothalamic dopaminergic receptors in the control of lordosis behavior in the female rat. Physiol Behav 1979; 22: 283-289.
26. Fernandez G et al. Separation of dopaminergic and serotonergic inhibitory mechanisms in the mediation of estrogen-induced lordosis behaviour in the rat. Pharmacol Biochem Behav 1987; 27: 93-98.
27. Cragnolini A et al. The role of melanocortin receptors in sexual behavior in female rats. Neuropeptides 2000; 34: 211-215.
28. Maswood N et al. 5-HT3 receptors in the ventromedial nucleus of the hypothalamus and female sexual behavior. Brain Res 1997; 769: 13-20.
29. Daniels D et al. Functionally-defined compartments of the lordosis neural circuit in the ventromedial hypothalamus in female rats. J Neurobiol 2000; 45: 1-13.
30. Erskine MS. Solicitation behavior in the estrous female rat: a review. Horm Behav 1989; 23: 473-502.
31. Brien SE et al. The conditioned response erection (CRE) - a new approach to modelling erectile responses in the rat. Int J Impot Res 2000; 12: 91-96.
32. Levin RJ, VIP, vagina, clitoral and periurethral glans - an update on human female genital arousal. Exp Clin Endocrinol 1991; 98: 61-69.
33. Goldstein I et al. Vasculogenic female sexual dysfunction: vaginal engorgement and clitoral erectile insufficiency syndromes. Int J Impot Res 1998; 10(Suppl 2): S84-S90.
34. Park K et al. Decreased circulating levels of estrogen alter vaginal and clitoral blood flow and structure in the rabbit. Int J Impot Res 2001; 13: 116-124.
35. Banting JD et al. Isolation and perfusion of the pudendal vasculature in male rats. J Urol 1995; 154: 587-590.
36. Hale TM et al. Antihypertensive drugs induce structural remodeling of the penile vasculature. J Urol 2001; 166: 739-745.
37. Okabe H et al. The penis is not protected-in hypertension there are vascular changes in the penis which are similar to those in other vascular beds. Int J Impot Res 1999; 11: 133-140.
38. Hale TM et al. Recovery of erectile function after brief aggressive antihypertensive therapy. J Urol 2002; 168: 348-354.
39. Dundar M et al. The effect of estrogen-replacement therapy on clitoral-cavernosal tissue in oophorectomized rats: a histoquantitative study by image analyzer. Urol Res 2001; 29: 317-320.
40. Berman JR et al. Effect of estrogen withdrawal on nitric oxide synthase expression and apoptosis in the rat vagina. Urology 1998; 51: 650-656.
41. Vemulapalli S et al. Sildenafil relaxes rabbit clitoral corpus cavernosum. Life Sci 2000; 67: 23-29.
42. Min K et al. Hemodynamic evaluation of the female sexual arousal response in an animal model. J Sex Marital Ther 2001; 27: 557-565.
43. Sadeghi N et al. Preliminary report on the development and characterization of rabbit clitoral smooth muscle cell culture. Int J Impot Res 1998; 10: 165-169.