Genistein Suppressed Upregulation of Vascular Endothelial Growth Factor Expression by Cobalt Chloride and Hypoxia in Rabbit Retinal Pigment Epithelium Cells

Journal of Ocular Pharmacology and Therapeutics

Volumn 19, Issue 5, 2003, Pages 457-464

  Wang, Bin ^a   Zou, Ying ^a   Yuan, Zhi Lan ^a   Xiao, Ji Gao ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COBALT CHLORIDE; GENISTEIN; VASCULOTROPIN;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONFOCAL LASER MICROSCOPY; DNA SYNTHESIS INHIBITION; DRUG EFFECT; EPITHELIUM CELL; EVOKED RESPONSE; HYPOXIA; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PIGMENT EPITHELIUM; PROTEIN EXPRESSION; RABBIT; RECEPTOR UPREGULATION; RETINA MACULA AGE RELATED DEGENERATION; SUBRETINAL NEOVASCULARIZATION;

EID: 0142244522     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/108076803322473015     Document Type: Article

References (19)

1. Suzuma, K., Takagi, H., Otani, A., Oh, H., and Honda Y. Expression of thrombospondin-1 in ischemia-induced retinal neovascularization. Am. J. Pathol. 154:343-354, 1999.
2. Krzystolik, M.G., Afshari, M.A., Adamis, A.P., Gaudreault, J., Gragoudas, E.S., Michaud, N.A., Li, W., Connolly, E., O'Neill, C.A., and Miller, J.W. Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch Ophthalmol. 120:338-346, 2002.
3. Noma, H., Funatsu, H., Yamashita, H., Kitano, S., Mishima, H.K., and Hori, S. Regulation of angiogenesis in diabetic retinopathy: possible balance between vascular endothelial growth factor and endostatin. Arch Ophthalmol. 120:1075-1080, 2002.
4. Kwak, N., Okamoto, N., Wood, J.M., and Campochiaro, P.A. VEGF is major stimulator in model of choroidal neovascularization. Invest. Ophthalmol. Vis. Sci. 41:3158-3164, 2000.
5. Fotsis, T., Pepper, M.S., Aktas, E., Breit, S., Rasku, S., Adlercreutz, H., Wahala, K., Montesano, R., and Schweigerer, L. Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis. Cancer Res. 57:2916-2921, 1997.
6. Polkowski, K., and Mazurek, A.P. Biological properties of genistein: a review of in vitro and in vivo data. Acta Pol. Pharm. 57:135-155, 2000.
7. Majji, A.B., Hayashi, A., Kim, H.C., Grebe, R.R., and de Juan, E., Jr. Inhibition of choriocapillaris regeneration with genistein. Invest. Ophthalmol. Vis. Sci. 40:1477-1486, 1999.
8. Shiragami, C., Matsuo, T., Shiraga, F., and Matsuo, N. Transplanted and repopulated retinal pigment epithelial cells on damaged Bruch's membrane in rabbits. Br. J. Ophthalmol. 82:1056-1062, 1998.
9. 2+ in cultured rat retinal pigment epithelial cells. J. Physiol 520(pt 3):745-759, 1999.
10. Hou, X.E., and Dahlstrom, A. Effects of decentralization on the levels of GAP-43 and p38 (synaptophysin) in sympathetic adrenergic neurons: a semi-quantitative study using immunofluorescence and confocal laser scanning microscopy. Brain Res. 679:49-63, 1995.
11. Gendron, R.L., Good, W.V., Adams, L.C., and Paradis, H. Suppressed expression of tubedown-1 in retinal neovascularization of proliferative diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 42:3000-3007, 2001.
12. Lutty, G., Grunwald, J., Majji, A.B., Uyama, M., and Yoneya, S. Changes in choriocapillaris and retinal pigment epithelium in age-related macular degeneration. Mol. Vis. 5:35, 1999.
13. Grossniklaus, H.E., Ling, J.X., Wallace, T.M., Dithmar, S., Lawson, D.H., Cohen, C., Elner, V.M., Elner, S.G., and Sternberg, P. Jr. Macrophage and retinal pigment epithelium expression of angiogenic cytokines in choroidal neovascularization. Mol. Vis. 8:119-126, 2002.
14. Liu, X.H., Kirschenbaum, A., Yao, S., Stearns, M.E., Holland, J.F., Claffey, K., and Levine, A.C. Upregulation of vascular endothelial growth factor by cobalt chloride-simulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human prostate cancer cell line. Clin. Exp. Metastasis. 17:687-694, 1999.
15. Ijichi, A., Sakuma, S., and Tofilon, P.J. Hypoxia-induced vascular endothelial growth factor expression in normal rat astrocyte cultures. Gila. 14:87-93, 1995.
16. Agani, F., and Semenza, G.L. Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity. Mol. Pharmacol. 54:749-754, 1998.
17. Bertges, D.J., Berg, S., Fink, M.P., and Delude, R.L. Regulation of hypoxia-inducible factor 1 in enterocytic cells. J. Surg. Res. 106:157-165, 2002.
18. Wang, G.L., Jiang, B.H., and Semenza, G.L. Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1. Biochem. Biophys. Res. Commun. 216:669-675, 1995.
19. Levy, A.P., Levy, N.S., and Goldberg, M.A. Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. J. Biol. Chem. 271:2746-2753, 1996.