Isoniazid induced hepatic steatosis - An acute toxicity study in rabbits

Biomedicine

Volumn 22, Issue 3-4, 2002, Pages 69-78

  Karthikeyan, S ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Cholesterol; Free Fatty Acids; Isoniazid; Phospholipid; Rabbits; Steatosis; Total Lipids; Triglyceride

Indexed keywords

CHOLESTEROL; DRUG METABOLITE; FATTY ACID; ISONIAZID; LIPID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPID; SODIUM CHLORIDE; TRIACYLGLYCEROL; TUBERCULOSTATIC AGENT;

ACUTE TOXICITY; ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; CONTROLLED STUDY; DOSE RESPONSE; FATTY ACID BLOOD LEVEL; FATTY LIVER; FEMALE; LIPID BLOOD LEVEL; LIPID LIVER LEVEL; LIPID TRANSPORT; LIVER NECROSIS; LIVER TOXICITY; MALE; NONHUMAN; PARAMETER; PHOSPHOLIPID BLOOD LEVEL; RABBIT; TISSUE LEVEL; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0142241158     PISSN: 09702067     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Robitzek, E.W., and Selikoff, I.J. Hydrazine derivatives of isonicotinic acid (Rimifon, Marsilid) in the treatment of acute progressive case-pneumatic tuberculosis. Am.Rev.Tuberc., 1952: 65: 402-428.
2. Randolph, H., and Joseph, S. Toxic hepatitis with jaundice occurring in a patient treated with isoniazid. J.A.M.A. 1952: 152: 38-40.
3. Davies, D., and Glowinski, J.J. Jaundice due to isoniazid. Tubercle. 1961: 42: 504-506.
4. Assem, E.S.K., Nooping, N., and Nicholson, H. Liver damage and isoniazid allergy. Clin.Exp.Immunol. 1969: 5: 439-442.
5. Scharer, L., and Smith, J.P. Serum transaminase elevations and other hepatic abnormalities in patients receiving isoniazid. Ann.Intern.Med. 1969: 71: 1113-1120,
6. Martin, C.E., and Asthaud, J.B. Hepatitis after isoniazid administration. N.Eng.J.Med. 1970: 282: 433-434.
7. Byrd, R.B., Nelson, R., and Elliott, R.C. Isoniazid toxicity. A prospective study in secondary chemoprophylaxis. J.A.M.A. 1972: 220: 1471-1473.
8. Rubin, A., and Burke, J.C. Absorption, distribution and excretion of isoniazid (Nydrazid) in the dog. J.Pharmacol. 1953: 107: 219-224.
9. Mc Kennis, H., Yard, A.S., and Pahnelas, E.V. The production of fatty livers in rabbits by isoniazid and their hydrazine derivatives. Am. Rev. Tuberc. 1956: 73: 956-959.
10. Raisefeld, I.H. Drug-induced liver disease: guinea pig model for isoniazid (INH) hepatitis. The predictive value of D-Glucourinic acid excretion. Gastroenterology. 1975: 69: 845-851.
11. 14C] acetylhydrazine by rat and rabbit. Fund.Appl.Toxicol. 1984: 4: 646-653.
12. Pessayre, D., Bentata, M., Degott, C., Noel, O., Miguet, J.P., Reuff, B., and Benhamou, B.P. Isoniazid-rifampicin fulminant hepatitis. A possible consequence of the enhancement of isoniazid hepatotoxicity by enzyme induction. Gastroenterology. 1977: 72: 284-289.
13. Pilheu, J.A., De Salvo, M.C., and Barcat, J.A. Action of the liver to schedules for treatment of tuberculosis containing isonizid and rifampicin. Medicina (Buenos Aires). 1979: 39: 298-304.
14. Pilheu, J.A., De Salvo, M.C., Koch, O., and Barcat, J.A. Light and electron microscopical studies of the liver of tuberculosis patients receiving rifampicin and isoniazid. Medicina (Beunos Aires). 1981: 41: 439-445.
15. Whitehouse, L.W., Tryphonas, L., Paul, C.J., Salomonraj, G., Thomas, B.H., and Wong, L.T. Isoniazid induced hepatic steatosis in rabbits: an explanation for susceptibility and its antagonism by pyridoxine hydrochloride. Can.J.Physiol. Pharmacol. 1983: 61(5): 478-487.
16. Karthikeyan, S., and Krishnamoorthy, M.S. Effect of subacute administration of isoniazid and pyridoxine on lipids in plasma, liver and adipose tissues in the rabbit. Drug Chem.Toxcol. 1991: 14(3): 293-303.
17. Krishnamoorthy, M.S., and Karthikeyan, S. Effect of phenobarbitone pretreatment on isoniazid-induced lipid changes in plasma, liver and adipose tissue in the rabbit. Pharmacol. Res. 1991: 24: 219-225.
18. Sarich, T.C., Adams, S.P., Petricca, G., and Wright, J.M. Inhibition of isoniazid-induced hepatotoxicity in rabbits by pretreatment with an amidease inhibitor. J.Pharmacol. Exp.Ther. 1999: 289(2): 695-702.
19. Folch, J., Lees, M., and Sloane Stanley, G.H, A simple method for the isolation and purification of total lipids from animal tissues. J.Biol.Chem. 1957: 226: 497-509.
20. Neskovic, N.M., and Kostic, D.M. Quantitative analysis of rat liver phospholipids by two-step thin layer chromatographic procedure. J.Chromatogr. 1968: 35: 297-300.
21. Fiske, C.H., and Subba Row, Y. The colorimetric determination of phosphorous. J.Biol.Chem. 1925: 66: 375-440.
22. Ziversmidt, D.B., and Davis, A.K. Microdetermination of plasma phospholipids by trichlorbacetic acid precipitation. J.Lab.Clin.Med. 1950; 35: 155-160.
23. Frings, C.S., and Dunn, R.T. A colorimetric method for determination of total lipids based on subphosphovanilline reaction. J.Clin.Pathol. 1970: 53: 89-91.
24. th Ed. Heinemann Medical Books Ltd., London. 1967: 313-317.
25. Chromy, V., Gergel, J., Vozineck, J., Knombbozova, L., and Musil, J. Assay of serum free fatty acids by extraction-photometric procedure. Clin. Chem. Acta. 1977: 80: 327-332.
26. Regouw, B.J.M., Cornelissen, P.J.H.C., Reit, A.P., Heider, J., Spijkers, J.B.F., and Webber, M.M.Y. Specific determination of free fatty acids in plasma. Clin.Chem.Acta. 1971: 31: 187-195.
27. th Ed. Heinemann Medical Books Ltd., London. 1980: 671-674.
28. Snedecor, G.W., and Cochran, W,G. In: Statistical Methods. Ames Iowa. Iowa State University Press, USA. 1967: 95-110.
29. Brown, C. Acute isoniazid poisoning. Am.Rev.Respir.Dis. 1972: 105: 206-215.
30. Kingston, R.L., and Sexena, K., Management of acute isoniazid overdosage. Clin.Tox.Consultant. 1980: 2(2): 37-44.
31. th Ed. Mac Millon Co., New York. 1980: 1200-1203.
32. 2 upon the metabolism of amino acids in the rat liver. Lab.Invest. 1963: 12: 921-928.
33. Lamb, R.G., and Banks, W.L. Effect of hydrazine exposure on hepatic triacylglycerol biosynthesis. Biochem. Biophys.Acta. 1979: 574: 440-447.
34. Zimmerman, H.C. In: Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. Appleton Century-Crofts, New York. 1978. 139-159.
35. Dianzani, M.U. In: Toxic injury of the liver. Part-A. Ed. Farber, A.E., and Fisher, M.M. Marcel Dekker. Inc., New York, Basel. 1979: 281-301