Combination of 3′ and 5′ IgH regulatory elements mimics the B-specific endogenous expression pattern of IgH genes from pro-B cells to mature B cells in a transgenic mouse model

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1642, Issue 3, 2003, Pages 181-190

  Guglielmi, Laurence ^a   Le Bert, Marc ^b   Comte, Isabelle ^a   Dessain, Marie Laure ^b   Drouet, Mireille ^a   Ayer Le Lievre, Christiane ^a   Cogné, Michel ^a   Denizot, Yves ^a  

^a CNRS   (France)

^b CDTA   (France)

Author keywords

3 LCR; B lymphocyte; E ; Gene regulation; Transgenic

Indexed keywords

ANTIGEN; CD45 ANTIGEN; GREEN FLUORESCENT PROTEIN; IMMUNOGLOBULIN D; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN M; LEUKOSIALIN; STEM CELL FACTOR RECEPTOR; TH 2 ANTIGEN; THY 1 ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; B LYMPHOCYTE DIFFERENTIATION; CELL LINEAGE; CELL MATURATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FLOW CYTOMETRY; GENE CASSETTE; GENE EXPRESSION; GENE LOCUS; GENETIC LINKAGE; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL; INTRON; MOLECULAR MIMICRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; STEM CELL; T LYMPHOCYTE; TRANSGENE; TRANSGENIC MOUSE; ANIMAL; ANTIBODY SPECIFICITY; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; DNA METHYLATION; GENE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOGLOBULIN GENE; METABOLISM; REGULATORY SEQUENCE; SPLEEN;

DROMAIUS NOVAEHOLLANDIAE; MUS MUSCULUS;

ANIMALS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINE; DNA METHYLATION; GENE EXPRESSION REGULATION; GENES, IMMUNOGLOBULIN; GENES, RAG-1; IMMUNOGLOBULIN HEAVY CHAINS; MICE; MICE, TRANSGENIC; ORGAN SPECIFICITY; REGULATORY SEQUENCES, NUCLEIC ACID; SPLEEN; TRANSGENES;

EID: 0142229938     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2003.08.005     Document Type: Article

References (26)

1. Henderson A., Calame K. Transcription regulation during B cell development. Annu. Rev. Immunol. 16:1998;163-200.
2. Madisen L., Groudine M. Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmocytoma and Burkitt's lymphoma cells. Genes Dev. 8:1994;2212-2226.
3. Chauveau C., Jansson E.A., Müller S., Cogné M., Pettersson S. Ig heavy chain 3′ HS1-4 directs correct spatial position-independent expression of a linked transgene to B lineage cells. J. Immunol. 163:1999;4637-4641.
4. Khamlichi A., Pinaud E., Decourt C., Chauveau C., Cogné M. The 3′ IgH regulatory region: a complex structure in a search for a function. Adv. Immunol. 75:2000;317-345.
5. Chauveau C., Pinaud E., Cogné M. Synergies between regulatory elements of the immunoglobulin heavy chain locus and its palindromic 3′ locus control region. Eur. J. Immunol. 28:1998;3048-3056.
6. Ong J., Stevens S., Roeder R.G., Eckhardt L.A. 3′ IgH enhancer elements shift synergistic interactions during B cell development. J. Immunol. 160:1998;4896-4903.
7. Ferrier P., Krippl B., Blackwell T.K., Furley A.J., Suh H., Winoto A., Cook W.D., Hood L., Costantini F., Alt F.W. Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate. EMBO J. 9:1990;117-125.
8. Jenuwein T., Grosschedl R. Complex pattern of immunoglobulin mu gene expression in normal and transgenic mice: nonoverlapping regulatory sequences govern distinct tissue specificities. Genes Dev. 5:1991;932-943.
9. Cook G.P., Meyer K.B., Neuberger M.S., Pettersson S. Regulated activity of the IgH intron enhancer (Eμ) in the T lymphocyte lineage. Int. Immunol. 7:1995;89-95.
10. Guglielmi L., Le Bert M., Cogné M., Denizot Y. Effect of the Eμ IgH enhancer on expression of a GFP reporter gene in transfected B cells and transgenic mice. Immunol. Lett. 86:2003;77-83.
11. Gagneten S., Le Y., Miller J., Sauer B. Brief expression of a GFPcre fusion gene in embryonic stem cells allows rapid retrieval of site specific genomic deletions. Nucleic Acids Res. 25:1997;3326-3331.
12. Pettersson S., Cook G.P., Bruggemann M., Williams G.T., Neuberger M.S. A second B cell-specific enhancer 3′ of the immunoglobulin heavy-chain locus. Nature. 344:1990;165-168.
13. Matthias P., Baltimore D. The immunoglobulin heavy chain locus contains another B-cell-specific 3′ enhancer close to the α constant region. Mol. Cell. Biol. 13:1993;1547-1553.
14. Chauveau C., Decourt C., Cogné M. Insertion of the IgH locus 3′ regulatory palindrome in expression vectors warrants sure and efficient expression in stable B cell transfectants. Gene. 222:1998;279-285.
15. Pinaud E., Khamlichi A.A., Le Morvan C., Drouet M., Nalesso V., Le Bert M., Cogné M. Localization of the 3′ IgH locus elements that effect long-distance regulation of class switch recombination. Immunity. 15:2001;187-199.
16. Mombaerts P., Iacomini J., Johnson R.S., Herrup K., Tonegawa S., Papaioannou V.E. RAG-1-deficient mice have no mature B and T lymphocytes. Cell. 68:1992;869-877.
17. Schaeren-Wiemers N., Gerfin-Mosen A. A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled RNA probes. Histochemistry. 100:1993;431-440.
18. Leibovici M., Lapointe F., Aletta P., Ayer-Le-Lièvre C. Avian olfactory receptors: differentiation of olfactory neurons under normal and experimental conditions. Dev. Biol. 175:1996;118-131.
19. Okada S., Nakauchi H., Nagayoshi K., Nishikawa S., Nishikawa S.I., Miura Y., Suda T. Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule. Blood. 78:1991;1706-1712.
20. hi cells coincides with commitment to the B cell lineage. Eur. J. Immunol. 28:1998;3850-3856.
21. Moore T., Huang S., Terstappen L.W., Bennett M., Kumar V. Expression of CD43 on murine and human pluripotent hematopoietic stem cells. J. Immunol. 153:1994;4978-4987.
22. Payne K.J., Medina K.L., Kincade P.W. Loss of c-kit accompanies B-lineage commitment and acquisition of CD45R by most murine B-lymphocyte precursors. Blood. 94:1999;713-723.
23. Tudor K.S., Payne K.J., Yamashita Y., Kincade P.W. Functional assessment of precursors from murine bone marrow suggests a sequence of early B lineage differentiation events. Immunity. 12:2000;335-345.
24. Naveh-Many T., Cedar H. Active gene sequences are undermethylated. Proc. Natl. Acad. Sci. U. S. A. 78:1981;4246-4250.
25. Holliday R. The inheritance of epigenetic defects. Science. 238:1987;163-170.
26. Hertz J.M., Schell G., Doerfler W. Factors affecting de novo methylation of foreign DNA in mouse embryonic stem cells. J. Biol. Chem. 274:1999;24232-24240.