Awareness of Deficits in Patients with Dementia of the Alzheimer Type;Zum Problem der Krankheitseinsicht bei Patienten mit Demenz vom Alzheimer-Typ

Fortschritte der Neurologie Psychiatrie

Volumn 71, Issue 10, 2003, Pages 541-548

  Kessler, Holger ^a   Supprian, T ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; ANOSOGNOSIA; AWARENESS; DAILY LIFE ACTIVITY; DEPRESSION; FRONTAL LOBE; HUMAN; PARIETAL LOBE; REVIEW; RISK ASSESSMENT;

AGED; ALZHEIMER DISEASE; AWARENESS; DEPRESSION; HUMANS; MAGNETIC RESONANCE IMAGING; MEMORY DISORDERS; NEUROPSYCHOLOGICAL TESTS;

EID: 0142229456     PISSN: 07204299     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-42874     Document Type: Review

References (97)

1. Säring W, Prosiegel M, Cramon D von. Zum Problem der Anosognosie und Anosodiaphorie bei hirngeschädigten Patienten. Nervenarzt 1988; 59: 129-137
2. Cramon DY von, Mai N, Ziegler W (eds). Neuropsychologische Diagnostik. London: Chapman & Hall, 1995: pp. 82-90
3. Wernicke C. Der aphasische Symptomenkomplex. Breslau: Cohn& Weigert, 1874 Translated in Boston Studies in Philosophy of Science, 4,: 34-97
4. Wernicke C. Der aphasische Symptomenkomplex. Breslau: Cohn& Weigert, 1874 Translated in Boston Studies in Philosophy of Science, 4,: 34-97
5. Westphal R. Zur Lokalisation der Hemianopsie und des Muskelgefühls beim Menschen. Charite Annalen 1882; 7: 467-489
6. Korsakoff S. Etude medico-psychologie sur une forme des maladies de la memoire. Revue Philosophique 1889; 5: 501-530
7. Anton G. Blindheit nach beiderseitiger Gehirnerkrankung mit Verlust der Orientierung im Raume. Mitt Verein d Ärzte i d Steiermark 1896; 33: 41-46
8. Anton G. Über Herderkrankungen des Gehirns, welche vom Patienten selbst nicht wahrgenommen werden. Wien Klin Wochenschr 1898; 11: 227-229
9. Anton G. Über die Selbstwahrnehmung der Herderkrankungen des Gehirns durch den Kranken bei Rindenblindheit und Rindentaubheit. Arch Psychiatr 1899; 32: 86-127
10. Babinski J. Contribution a l'etude des troubles mentaux dans l'hemiplegie organique cerebrale (Anosognosie). Rev Neurol 1914; 27: 845-848
11. Flashman LA. Disorders of awareness in neuropsychiatric syndromes: an update. Current Psychiatry Reports 2002; 4: 346-353
12. Sevush S, Leve N. Denial of memory deficit in Alzheimer's disease. Am J Psychiatry 1993; 150: 748-751
13. Schacter D, McLachlan D, Moscovitch M, Tulving E. Monitoring of recall performance by memory disordered patients. J Clin Exp Neuropsychol 1986; 8: 130 (Abstract)
14. Lopez OL, Becker JT, Somsak D, Dew MA, DeKosky ST. Awareness of cognitive deficits and anosognosia in probable Alzheimer's disease. Eur Neurol 1994; 34: 277-282
15. Green J, Goldstein FC, Sirockman BE, Green RC. Variable awareness of deficits in Alzheimer's disease. Neuropsychiatry Neuropsychol Behav Neurol 1993; 6 (3): 159-165
16. Derouesene C, Thibault S, Lagha-Pierucci S, Baudouin-Madec V, Ancri D, Lacomblez L. Decreased awareness of cognitive deficits in patients with mild dementia of the Alzheimer type. Int J Geriat Psychiatry 1999; 14: 1019-1030
17. Rösler M, Frey U, Retz-Junginger P, Supprian T, Retz W. Diagnostik der Demenzen: Standardisierte Untersuchungsinstrumente im Überblick. Fortschr Neurol Psychiat 2003; 71: 187-198
18. Amador XF, Strauss DH, Yale SA, Gorman JM. Awareness of illness in schizophrenia. Schizophr Bull 1991; 17 (1): 113-132
19. McEvoy JP, Apperson LJ, Appelbaum PS, Ortlip P, Brecosky J, Hammill K, Geller JL, Roth L. Insight in schizophrenia. Its relationship to acute psychopathology. J Nerv Ment Dis 1989; 177 (1): 43-47
20. DeBettignies BH, Mahurin RK, Pirozzolo FJ. Insight for impairment in independent living skills in Alzheimer's disease and multi-infarct dementia. J Clin Exp Neuropsychol 1990; 12 (2): 355-363
21. Wade J, Mirsen T, Hachinski V. The clinical diagnosis of Alzheimer's disease. Arch Neurol 1987; 44: 24-29
22. Kaplan JG, Katzman R, Horoupian DS, Fuld PA, Mayeux R, Hays AP. Progressive dementia, visual deficits, amyotrophy, and microinfarcts. Neurology 1985; 35: 789-796
23. Danielczyk W. Various mental behavioral disorders in Parkinson's disease, primary degenerative senile dementia, and multiple infarction dementia. J Neural Transm 1983; 56: 161-176
24. Gustafson I, Nilsson L. Differential diagnosis of presenile dementia on clinical grounds. Acta Psychiatr Scand 1982; 65: 194-209
25. Migliorelli R, Teson A, Sabe L, Petracca G, Petracchi M, Leiguarda R, Starkstein SE. Anosognosia in Alzheimer's disease: a study of associated factors. Journal of Neuropsychiatry and Clinical Neurosciences 1995; 7: 338-344
26. Reed BR, Jagust WJ, Coulter L. Anosognosia in Alzheimer's disease: relationship to depression, cognitive function and cerebral perfusion. J Clin Exp Neuropsychol 1993; 15: 231-244
27. Teri L, Wagner A. Assessment of depression in patients with Alzheimer's disease: concordance among informants. Psychol Aging 1991; 6: 280-285
28. Burke WJ, Rubin EH, Morris J, Berg L. Symptoms of "depression" in senile dementia of the Alzheimer's type. Alzheimer Dis Assoc Disord 1988; 2: 356-362
29. Kotler-Cope S, Camp CJ. Anosognosia in Alzheimer disease. Alzheimer Dis Assoc Disord 1995; 9 (1): 52-56
30. Vasterling JJ, Seltzer B, Foss JW, Vanderbrook V. Unawareness of deficit in Alzheimer's disease: Domain-specific differences and disease correlates. Neuropsychiatry Neuropsychol Behav Neurol 1995; 8: 26-32
31. Feher EP, Mahurin RK, Inbody SB, Crook TH, Pirozzolo FJ. Anosognosia in Alzheimer's disease. Neuropsychiatry Neuropsychol Behav Neurol 1991; 4: 136-146
32. Sunderland A, Harris JE, Baddeley AD. Do laboratory tests predict everyday memory? A neuropsychological study. J Verbal LearningVerbal Behav 1983; 22: 341-357
33. Kuriansky JB, Gurland BJ, Fleiss JL. The assessment of self-care capacity in geriatric psychiatric patients by objective and subjective methods. J Clin Psychol 1976; 32: 95-102
34. Mangone CA, Hier DB, Gorelik PB, Ganellen RJ, Langenberg RJ, Boarman R, Dollear WC. Impaired insight in Alzheimer's disease. J Geriatr Psychiat Neurol 1991; 4: 189-193
35. Welman A. Right-sided unilateral visual spatial anosognosia with left hemisphere lesions. Brain 1969; 92: 571-580
36. Cutting J. Study of anosognosia. J Neurol Neurochir Psychiatr 1978; 41: 546-555
37. Green J, Hamilton W. Anosognosia for hemiplegia: somatosensory evoked potential studies. Neurol 1976; 26: 1141-1144
38. Bisiach E, Vallar G, Perani D, Papagno C, Berti A. Unawareness of disease following lesions of the right hemisphere: Anosognosia for hemiplegia and anosognosia for hemianopsia. Neuropsychologia 1986; 24: 471-482
39. Schacter DL. Toward a cognitive neuropsychology of awareness: Implicit knowledge and anosognosia. J Clin Exp Neuropsychol 1990; 12 (1): 155-178
40. Stuss DT, Benson DF. The Frontal Lobes. New York: Raven Press, 1986
41. Jahro L. Korsakoff-like amnesic syndrome in penetrating brain injury. Acta Neurol Scand 1973; 49: 44-67
42. Luria AR. The neuropsychology of memory. New York: Wiley, 1976
43. McGlynn SM, Schacter DL. Unawareness of deficits in neuropsychological syndromes. J Clin Exp Neuropsychol 1989; 11 (2): 143-205
44. Moossy J, Zubenko GS, Martinez AJ, Rao GR, Kopp U, Hanin I. Lateralization of brain morphologic and cholinergic abnormalities in Alzheimer's disease. Arch Neurol 1989; 46: 639-642
45. Zubenko GS, Moossy J, Martinez J, Rao GR, Kopp U, Hanin I. A brain regional analysis of morphologic and cholinergic abnormalities in Alzheimer's disease. Arch Neurol 1989; 46: 634-638
46. Waldemar G, Hogh P, Paulson OB. Functional brain imaging with single-photon emission computed tomography in the diagnosis of Alzheimer's disease. Int Psychogeriat 1997; 9 (Suppl. 1): 223-227
47. Jagust WJ, Reed BR, Seab JP, Budinger TF. Alzheimer's disease: age at onset and SPECT patterns of regional cerebral blood flow. Arch Neurol 1990; 47: 628-6233
48. Haxby JV, Grady CL, Koss E, Horwitz B, Heston L, Schapiro M, Friedland RP, Rapoport SI. Longitudinal study of cerebral metabolic asymmetries and associated neuropsychological patterns in early dementia of the Alzheimer type. Arch Neurol 1990; 47: 753-760
49. Celsis P, Agniel A, Puel M, Rascol A, Marc-Vergnes JP. Focal cerebral hypoperfusion and selective cognitive deficit in dementia of the Alzheimer type. J Neurol Neurosurg Psychiat 1987; 50: 1602-1612
50. Cohen MB, Graham LS, Lake R, Metter EJ, Fitten J, Kulkarni MK, Sevrin R, Yamada L, Chang CC, Woodruff N, Kling AS. Diagnosis of Alzheimer's disease and multiple infarct dementia by tomographic imaging iodine-123 IMP. Journal of Nuclear Medicine 1986; 27: 769-774
51. Duara R, Grady C, Haxby J, Sundaram M, Cutler NR, Heston L, Moore A, Schlageter N, Larson S, Rapoport SI. Positron emission tomography in Alzheimer's disease. Neurology 1986; 36: 879-887
52. Friedland RP, Budinger TF, Koss E, Ober BA. Alzheimer's disease: Anterior-posterior and lateral hemispheric alterations in cortical glucose utilization. Neuroscience Letters 1985; 53: 235-240
53. Starkstein SE, Vazquez S, Migliorelli R, Teson A, Sabe L, Leiguarda R. A single-photon emission computed tomographic study of anosognosia in Alzheimer's disease. Arch Neurol 1995; 52: 415-420
54. Ott BR, Noto RB, Fogel BS. Apathy and loss of insight in Alzheimer's disease: a SPECT imaging study. J Neuropsychiatry Clin Neurosci 1996; 8: 41-46
55. Drewe EA. Go-no-go learning after frontal lobe lesions in humans. Cortex 1975; 11: 8-16
56. Reitan RM. Validity of the Trail Making Test as an indicator of organic brain damage. Percep Mot Skills 1958; 8: 271-276
57. Michon A, Deweer B, Pillon B, Agid Y, Dubois B. Relation of anosognosia to frontal lobe dysfunction in Alzheimer's disease. J Neurol Neurosurg Psychiatry 1994; 57: 805-809
58. Nelson HE. A modified card sorting test sensitive to frontal lobe defect. Cortex 1976; 12: 313-324
59. Benton AL. Differential behavioral effects in frontal lobe disease. Neuropsychologia 1968; 6: 53-60
60. Luria AR. Higher cortical functions in man. New York: Basic Books,: 1966
61. David AS. Frontal lobology-psychiatiy's new pseudoscience. Brit J Psychiat 1992; 161: 244-248
62. Auchus AP, Goldstein FC, Green J, Green RC. Unawareness of cognitive impairments in Alzheimer's disease. Neuropsychiatry Neuropsychol Behav Neurol 1994; 7 (1): 25-29
63. Wechsler D. WAIS-R manual. New York: Psychological Corporation, 1981
64. Goodglass H, Kaplan E. The assessment of aphasia and related disorders. Philadelphia: Lea & Febiger, 1983
65. Critchley M. The parietal lobes. London: Edward Arnold, 1969
66. Newcombe F. Missile wounds of the brain. London: Oxford University Press, 1969
67. Luria AR. The frontal lobes and the regulation of behavior. In: Pribram KH, Luria Ar (eds.): Psychophysiology of the frontal lobes. New York: Academic Press, 1973
68. Black FW, Strub RL. Constructional apraxia in patients with discrete missile wounds of the brain. Cortex 1976; 14: 12-21
69. Springer SP, Deutsch G. Left brain, right brain. New York: WH Freeman, 1981
70. Lezak MD. Neuropsychology assessment, 2nd ed. New York: Oxford University Press, 1983
71. Schacter DL. Unawareness of deficit and unawareness of knowledge in patients with memory disorders. In: Prigatano GP, Schacter DL (eds.): Awareness of deficit after brain injury. New York: Oxford University Press, 1991: pp. 127-151
72. Fischer P, Simanyi M, Danielczyk W. Depression in dementia of the Alzheimer type and in multi-infarct dementia. Am J Psychiat 1990; 147:1484-1487
73. Wragg RE, Jeste DV. Overview of depression and psychosis in Alzheimer's disease. Am J Psychiat 1989; 146: 577-587
74. Lazarus LW, Newton N, Cohler B, Lesser J, Schweon C. Frequency and presentation of depressive symptoms in patients with primary degenerative dementia. Am J Psychiat 1987; 144: 41-45
75. McAllister TW, Price TRP. Severe depressive pseudodementia with and without dementia. Am J Psychiat 1982; 139: 626-629
76. Cummings JL, Miller B, Hill MA. Neuropsychiatric aspects of multi-infarct dementia and dementia of the Alzheimer type. Arch Neurol 1987; 44: 389-393
77. Pearson JL, Teri L, Reifler BV, Rashkind MA. Functional status and cognitive impairment in Alzheimer's patients with and without depression. J Am Geriatr Soc 1989; 37: 1117-1121
78. Reifler BV, Larson E, Hanley R. Co-existence of cognitive impairment and depression in geriatric outpatients. Am J Psychiatry 1982; 139: 623-626
79. Blass JP, Barclay LL. New developments in the diagnosis of dementias. Drug Dev Res 1985; 5: 39-58
80. Kral VA. The relationship between senile dementia (Alzheimer type) and depression. Canadian Journal of Psychiatry 1983; 28: 304-306
81. Verhey FRJ, Rozendaal N, Ponds RWHM, Jolles J. Dementia, awareness and depression. Int J Geriatr Psychiat 1993; 851-856
82. Reisberg B, Gordon B, McCarthy M, Ferris SH. Clinical symptoms accompanying progressive cognitive decline and Alzheimer's disease. In: Melnick VL, Dubler NN (eds.): Alzheimer's dementia. Clifton, NJ: Humana Press, 1985: pp. 19-39
83. McGlynn SM, Kaszniak AW. When metacognition fails: impaired awareness of deficit in Alzheimer's disease. J Cogn Neurosci 1991; 3: 183-189
84. Schneck MK, Reisberg B, Ferris SH. An overview of current concepts of Alzheimer's disease. Am J Psychiatry 1982; 139: 165-173
85. Folstein MF, Folstein SE, McHugh PR. "Mini-Mental State"; a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-198
86. Harwood DG, Sultzer DL, Wheatley MV. Impaired insight in Alzheimer disease: association with cognitive deficits, psychiatric symptoms, and behavioral disturbances. Neuropsychiatry Neuropsychol Behav Neurol 2000; 13 (2): 83-88
87. Starkstein SE, Sabe L, Chemerinski E, Jason L, Leiguarda R. Two domains of anosognosia in Alzheimer's disease. J Neurol Neurosurg Psychiat 1996; 10: 96-101
88. McDaniel KD, Edland SD, Heyman A, and the CERAD clinical investigators. Relationship between level of insight and severity of dementia in Alzheimer disease. Alz Dis Assoc Disord 1995; 9 (2): 101-104
89. Sultzer DL, Levin HS, Mahler ME, High WM, Cummings JF. Assessment of cognitive, psychiatric and behavioral disturbances in patients with dementia: the Neurobehavioral Rating Scale. J Am Geriatr Soc 1992; 40: 549-555
90. Feehan M, Knight RG, Partridge FM. Cognitive complaint and test performance in elderly patients suffering depression or dementia. Int J Geriatr Psychiat 1991; 6: 287-294
91. Kaszniak AW, Christenson GD. One-year longitudinal changes in the metamemory impairment of Alzheimer's disease. J Int Neuropsychological Soc 1995; 1: 145
92. Vasterling JJ, Seltzer B, Watrous WE. Longitudinal assessment of deficit unawareness in Alzheimer's disease. Neuropsychiatry Neuropsychol Behav Neurol 1997; 10 (3): 197-202
93. Weinstein EA, Friedland RP, Wagner EL. Denial/unawareness of impairment and symbolic behavior in Alzheimer's disease. Neuropsychiatry Neuropsychol Behav Neurol 1994; 7: 176-184
94. Baumann B. Die Feststellung des Einverständnisses zur Behandlung bei Patienten in Neurologie und Psychiatrie - Vorschlag eines gestuften Entscheidungsablaufs. Fortschr Neurol Psychiat 2003; 71: 205-210
95. David A, Buchanan A, Reed A, Almeida O. The assessment of insight in psychosis. Brit J Psychiat 1992; 161: 599-602
96. Prigatano GP. The relationship of frontal lobe damage to diminished awareness: studies in rehabilitation. In: Levin HS, Eisenberg HM, Benton AL (eds.): Frontal lobe function and dysfunction. New York: Oxford University Press, 1991: pp. 381-397
97. Bergman K, Proctor S, Prudham D. Symptom profiles in hospital and community resident elderly persons with dementia. In: Hofmeister F, Muller C (eds.): Brain Function in Old Age. New York: Springer Verlag, 1979: pp. 60-67